Seroprevalence of Bordetella pertussis immunoglobulin G antibodies among children in Samsun, Turkey
In this study, we aimed to investigate anti-pertussis immunoglobulin (Ig) G antibodies in the serum of children in our region vaccinated against pertussis with four doses. Between August 2008-2009, antibody levels to Bordetella pertussis (B. pertussis) antigens were studied in 385 serum sampl...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2012-02-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1582 |
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| author | Atay Ozkal Gülnar Sensoy Cağatay Acuner Nurşen Belet Akif Koray Güney |
| author_facet | Atay Ozkal Gülnar Sensoy Cağatay Acuner Nurşen Belet Akif Koray Güney |
| author_sort | Atay Ozkal |
| collection | DOAJ |
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In this study, we aimed to investigate anti-pertussis immunoglobulin (Ig) G antibodies in the serum of children in our region vaccinated against pertussis with four doses. Between August 2008-2009, antibody levels to Bordetella pertussis (B. pertussis) antigens were studied in 385 serum samples from healthy children aged 1.5-18 years (y) vaccinated against pertussis in Samsun, Turkey. The study population was divided into six groups according to ages: 1.5-3 y; 4-5 y; 6-8 y; 10-12 y; 13-15 y; and 16-18 y. IgG antibodies to B. pertussis antigens were measured with a commercial ELISA kit. Mean age of the children was 9.6 +/- 5.3 y. Anti-pertussis IgG titers were positive in 48.3% of the cases. The lowest positivity rate was determined in the 4-5 y age group (28.1%) and the highest rate in the 16-18 y age group (64.2%). Geometric mean titer of anti-pertussis antibodies was 39.2 IU/ml, and again the lowest value was obtained in the 4-5 y age group (23.3 IU/ml) and the highest in the 16-18 y age group (51.4 IU/ml). The antibody levels to B. pertussis antigens significantly decrease 4-6 years after vaccination and again increase in school children, possibly due to natural infection.
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| format | Article |
| id | doaj-art-e5f1ff71dd0d43d28e9634e8605682e1 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2012-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-e5f1ff71dd0d43d28e9634e8605682e12025-08-20T02:01:56ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212012-02-01541Seroprevalence of Bordetella pertussis immunoglobulin G antibodies among children in Samsun, TurkeyAtay Ozkal0Gülnar SensoyCağatay AcunerNurşen BeletAkif Koray GüneyDivision of Pediatric Infectious Diseases, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey. In this study, we aimed to investigate anti-pertussis immunoglobulin (Ig) G antibodies in the serum of children in our region vaccinated against pertussis with four doses. Between August 2008-2009, antibody levels to Bordetella pertussis (B. pertussis) antigens were studied in 385 serum samples from healthy children aged 1.5-18 years (y) vaccinated against pertussis in Samsun, Turkey. The study population was divided into six groups according to ages: 1.5-3 y; 4-5 y; 6-8 y; 10-12 y; 13-15 y; and 16-18 y. IgG antibodies to B. pertussis antigens were measured with a commercial ELISA kit. Mean age of the children was 9.6 +/- 5.3 y. Anti-pertussis IgG titers were positive in 48.3% of the cases. The lowest positivity rate was determined in the 4-5 y age group (28.1%) and the highest rate in the 16-18 y age group (64.2%). Geometric mean titer of anti-pertussis antibodies was 39.2 IU/ml, and again the lowest value was obtained in the 4-5 y age group (23.3 IU/ml) and the highest in the 16-18 y age group (51.4 IU/ml). The antibody levels to B. pertussis antigens significantly decrease 4-6 years after vaccination and again increase in school children, possibly due to natural infection. https://turkjpediatr.org/article/view/1582 |
| spellingShingle | Atay Ozkal Gülnar Sensoy Cağatay Acuner Nurşen Belet Akif Koray Güney Seroprevalence of Bordetella pertussis immunoglobulin G antibodies among children in Samsun, Turkey The Turkish Journal of Pediatrics |
| title | Seroprevalence of Bordetella pertussis immunoglobulin G antibodies among children in Samsun, Turkey |
| title_full | Seroprevalence of Bordetella pertussis immunoglobulin G antibodies among children in Samsun, Turkey |
| title_fullStr | Seroprevalence of Bordetella pertussis immunoglobulin G antibodies among children in Samsun, Turkey |
| title_full_unstemmed | Seroprevalence of Bordetella pertussis immunoglobulin G antibodies among children in Samsun, Turkey |
| title_short | Seroprevalence of Bordetella pertussis immunoglobulin G antibodies among children in Samsun, Turkey |
| title_sort | seroprevalence of bordetella pertussis immunoglobulin g antibodies among children in samsun turkey |
| url | https://turkjpediatr.org/article/view/1582 |
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