Gut microbiota-derived glutathione from metformin treatment alleviates intestinal ferroptosis induced by ischemia/reperfusion

Gut microbiota-derived glutathione from metformin treatment alleviates intestinal ferroptosis induced by ischemia/reperfusion

Abstract Background Intestinal ischemia/reperfusion injury (IIRI) is a life-threatening condition caused by multiple organ and system failures induced by dysbiosis and gut leakage. Metformin has demonstrated efficacy in protecting against IIRI, although the precise role of the gut microbiota in the...

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Main Authors: Fangyan Wang, Xinyu Wang, Chaoyi Wang, Wangxin Yan, Junpeng Xu, Zhengyang Song, Mingli Su, Jingjing Zeng, Qiannian Han, Gaoyi Ruan, Eryao Zhang, Wantie Wang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Medicine
Subjects:
Metformin
Intestinal ischemia/reperfusion injury
Ferroptosis
Gut microbiota
Glutathione
Online Access:https://doi.org/10.1186/s12916-025-04119-6
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