Epidemic characteristics of measles and efforts to control measles infections in Zhejiang Province, China

OBJECTIVES Several countries have successfully eliminated measles, and China is making significant strides toward achieving this goal. This study focused on investigating the patterns of measles infections in Zhejiang Province, China, as well as control measures. The objective was to provide valuabl...

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Main Authors: Rui Yan, Mengya Yang, Hanqing He, Yan Feng, Yang Zhou, Xuewen Tang, Xuan Deng, Yao Zhu, Yuxia Du, Can Chen, Cao Kexin, Shigui Yang
Format: Article
Language:English
Published: Korean Society of Epidemiology 2024-09-01
Series:Epidemiology and Health
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Online Access:http://www.e-epih.org/upload/pdf/epih-46-e2024075.pdf
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author Rui Yan
Mengya Yang
Hanqing He
Yan Feng
Yang Zhou
Xuewen Tang
Xuan Deng
Yao Zhu
Yuxia Du
Can Chen
Cao Kexin
Shigui Yang
author_facet Rui Yan
Mengya Yang
Hanqing He
Yan Feng
Yang Zhou
Xuewen Tang
Xuan Deng
Yao Zhu
Yuxia Du
Can Chen
Cao Kexin
Shigui Yang
author_sort Rui Yan
collection DOAJ
description OBJECTIVES Several countries have successfully eliminated measles, and China is making significant strides toward achieving this goal. This study focused on investigating the patterns of measles infections in Zhejiang Province, China, as well as control measures. The objective was to provide valuable insights that could contribute to the development of nationwide elimination strategies. METHODS We analyzed measles surveillance data from 2005 to 2022 in Zhejiang Province. We utilized a joinpoint regression model to examine trends in measles. Additionally, we employed SaTScan version 9.5 to identify spatial-temporal clusters. Finally, we used an age-period-cohort model to assess the effects of age, period, and cohort. RESULTS The age-standardized incidence rate (ASIR) of measles infection in Zhejiang Province from 2005 to 2022 was 5.24 per 100,000, showing a consistent and significant downward trend with an annual percentage change of -24.93% (p<0.05). After 2020, the ASIR for measles infection fell to below 0.1 per 100,000. The majority of measles cases occurred in individuals either without an immunization history or with an unknown immunization status, representing 41.06% and 41.40% of the cases from 2010 to 2022, respectively. According to data from the National Measles Surveillance System, the annual rate of discarded measles cases from 2009 to 2014, and the annual rate of discarded measles and rubella cases from 2015 to 2022, were both above 2 per 100,000, indicating the high sensitivity of the measles surveillance system. CONCLUSIONS The significant reduction in measles incidence from 2005 to 2022 demonstrates substantial progress in Zhejiang Province towards the elimination of measles.
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spelling doaj-art-e5ec3f8276254cf78f4fa30c946dced82025-08-20T03:12:36ZengKorean Society of EpidemiologyEpidemiology and Health2092-71932024-09-014610.4178/epih.e20240751541Epidemic characteristics of measles and efforts to control measles infections in Zhejiang Province, ChinaRui Yan0Mengya Yang1Hanqing He2Yan Feng3Yang Zhou4Xuewen Tang5Xuan Deng6Yao Zhu7Yuxia Du8Can Chen9Cao Kexin10Shigui Yang11 Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China Quzhou People’s Hospital, Zhejiang, China Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China Department of Epidemiology and Biostatistics, School of Public Health, Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Department of Epidemiology and Biostatistics, School of Public Health, Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Department of Epidemiology and Biostatistics, School of Public Health, Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Department of Epidemiology and Biostatistics, School of Public Health, Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOBJECTIVES Several countries have successfully eliminated measles, and China is making significant strides toward achieving this goal. This study focused on investigating the patterns of measles infections in Zhejiang Province, China, as well as control measures. The objective was to provide valuable insights that could contribute to the development of nationwide elimination strategies. METHODS We analyzed measles surveillance data from 2005 to 2022 in Zhejiang Province. We utilized a joinpoint regression model to examine trends in measles. Additionally, we employed SaTScan version 9.5 to identify spatial-temporal clusters. Finally, we used an age-period-cohort model to assess the effects of age, period, and cohort. RESULTS The age-standardized incidence rate (ASIR) of measles infection in Zhejiang Province from 2005 to 2022 was 5.24 per 100,000, showing a consistent and significant downward trend with an annual percentage change of -24.93% (p<0.05). After 2020, the ASIR for measles infection fell to below 0.1 per 100,000. The majority of measles cases occurred in individuals either without an immunization history or with an unknown immunization status, representing 41.06% and 41.40% of the cases from 2010 to 2022, respectively. According to data from the National Measles Surveillance System, the annual rate of discarded measles cases from 2009 to 2014, and the annual rate of discarded measles and rubella cases from 2015 to 2022, were both above 2 per 100,000, indicating the high sensitivity of the measles surveillance system. CONCLUSIONS The significant reduction in measles incidence from 2005 to 2022 demonstrates substantial progress in Zhejiang Province towards the elimination of measles.http://www.e-epih.org/upload/pdf/epih-46-e2024075.pdfmeaslesepidemiological trendsvaccineschina
spellingShingle Rui Yan
Mengya Yang
Hanqing He
Yan Feng
Yang Zhou
Xuewen Tang
Xuan Deng
Yao Zhu
Yuxia Du
Can Chen
Cao Kexin
Shigui Yang
Epidemic characteristics of measles and efforts to control measles infections in Zhejiang Province, China
Epidemiology and Health
measles
epidemiological trends
vaccines
china
title Epidemic characteristics of measles and efforts to control measles infections in Zhejiang Province, China
title_full Epidemic characteristics of measles and efforts to control measles infections in Zhejiang Province, China
title_fullStr Epidemic characteristics of measles and efforts to control measles infections in Zhejiang Province, China
title_full_unstemmed Epidemic characteristics of measles and efforts to control measles infections in Zhejiang Province, China
title_short Epidemic characteristics of measles and efforts to control measles infections in Zhejiang Province, China
title_sort epidemic characteristics of measles and efforts to control measles infections in zhejiang province china
topic measles
epidemiological trends
vaccines
china
url http://www.e-epih.org/upload/pdf/epih-46-e2024075.pdf
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