3D‐Printed Breast Prosthesis that Smartly Senses and Targets Breast Cancer Relapse
Abstract Breast reconstruction is essential for improving the appearance of patients after cancer surgery. Traditional breast prostheses are not appropriate for those undergoing partial resections and cannot detect and treat locoregional recurrence. Personalized shape prostheses that can smartly sen...
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Wiley
2024-12-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202402345 |
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| author | Lu Wang Chenyang Ye Xiangjie Xue Mingjun Xie Yicheng Zhi Xiao Feng Pengcheng Zhao Jichun Zhou Mi Mi Jinrui Li Qinhao Gu Ye Zhao Jiaxin Chen Yi Zhou Yanan Xue Zexin Fu Liuyi Zhou Lulu Chen Lei Pan Yi Sun Linbo Wang Sufan Wu Yong He Ji Wang |
| author_facet | Lu Wang Chenyang Ye Xiangjie Xue Mingjun Xie Yicheng Zhi Xiao Feng Pengcheng Zhao Jichun Zhou Mi Mi Jinrui Li Qinhao Gu Ye Zhao Jiaxin Chen Yi Zhou Yanan Xue Zexin Fu Liuyi Zhou Lulu Chen Lei Pan Yi Sun Linbo Wang Sufan Wu Yong He Ji Wang |
| author_sort | Lu Wang |
| collection | DOAJ |
| description | Abstract Breast reconstruction is essential for improving the appearance of patients after cancer surgery. Traditional breast prostheses are not appropriate for those undergoing partial resections and cannot detect and treat locoregional recurrence. Personalized shape prostheses that can smartly sense tumor relapse and deliver therapeutics are needed. A 3D‐printed prosthesis that contains a therapeutic hydrogel is developed. The hydrogel, which is fabricated by crosslinking the polyvinyl alcohol with N1‐(4‐boronobenzyl)‐N3‐(4‐boronophenyl)‐N1, N1, N3, N3‐tetramethylpropane‐1,3‐diaminium, is responsive to reactive oxygen species (ROS) in the tumor microenvironment. Specifically, RSL3, a ferroptosis inducer that is loaded in hydrogels, can trigger tumor ferroptosis. Intriguingly, RSL3 encapsulated in the ROS‐responsive hydrogel exerts antitumor effects by increasing the numbers of tumor‐infiltrated CD4+ T cells, CD8+ T cells, and M1 macrophages while reducing the number of M2 macrophages. Therefore, this new prosthesis not only allows personalized shape reconstruction, but also detects and inhibits tumor recurrence. This combination of aesthetic appearance and therapeutic function can be very beneficial for breast cancer patients undergoing surgery. |
| format | Article |
| id | doaj-art-e5ec0918afb54497aff5655b578adf6f |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-e5ec0918afb54497aff5655b578adf6f2025-08-20T02:50:00ZengWileyAdvanced Science2198-38442024-12-011146n/an/a10.1002/advs.2024023453D‐Printed Breast Prosthesis that Smartly Senses and Targets Breast Cancer RelapseLu Wang0Chenyang Ye1Xiangjie Xue2Mingjun Xie3Yicheng Zhi4Xiao Feng5Pengcheng Zhao6Jichun Zhou7Mi Mi8Jinrui Li9Qinhao Gu10Ye Zhao11Jiaxin Chen12Yi Zhou13Yanan Xue14Zexin Fu15Liuyi Zhou16Lulu Chen17Lei Pan18Yi Sun19Linbo Wang20Sufan Wu21Yong He22Ji Wang23Center for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaDepartment of Medical Oncology Key Laboratory of Cancer Prevention and Intervention The Second Affiliated Hospital of Zhejiang University School of Medicine Cancer Center Zhejiang University Hangzhou 310058 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaDepartment of Surgical Oncology Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou 310016 ChinaDepartment of Medical Oncology Key Laboratory of Cancer Prevention and Intervention The Second Affiliated Hospital of Zhejiang University School of Medicine Cancer Center Zhejiang University Hangzhou 310058 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaDepartment of Surgical Oncology Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou 310016 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaState Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical Engineering Zhejiang University Hangzhou 310058 ChinaCenter for Plastic & Reconstructive Surgery Department of Plastic & Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou 310014 ChinaAbstract Breast reconstruction is essential for improving the appearance of patients after cancer surgery. Traditional breast prostheses are not appropriate for those undergoing partial resections and cannot detect and treat locoregional recurrence. Personalized shape prostheses that can smartly sense tumor relapse and deliver therapeutics are needed. A 3D‐printed prosthesis that contains a therapeutic hydrogel is developed. The hydrogel, which is fabricated by crosslinking the polyvinyl alcohol with N1‐(4‐boronobenzyl)‐N3‐(4‐boronophenyl)‐N1, N1, N3, N3‐tetramethylpropane‐1,3‐diaminium, is responsive to reactive oxygen species (ROS) in the tumor microenvironment. Specifically, RSL3, a ferroptosis inducer that is loaded in hydrogels, can trigger tumor ferroptosis. Intriguingly, RSL3 encapsulated in the ROS‐responsive hydrogel exerts antitumor effects by increasing the numbers of tumor‐infiltrated CD4+ T cells, CD8+ T cells, and M1 macrophages while reducing the number of M2 macrophages. Therefore, this new prosthesis not only allows personalized shape reconstruction, but also detects and inhibits tumor recurrence. This combination of aesthetic appearance and therapeutic function can be very beneficial for breast cancer patients undergoing surgery.https://doi.org/10.1002/advs.2024023453D‐printed prosthesisbreast reconstructiondrug deliveryrelapse treatment |
| spellingShingle | Lu Wang Chenyang Ye Xiangjie Xue Mingjun Xie Yicheng Zhi Xiao Feng Pengcheng Zhao Jichun Zhou Mi Mi Jinrui Li Qinhao Gu Ye Zhao Jiaxin Chen Yi Zhou Yanan Xue Zexin Fu Liuyi Zhou Lulu Chen Lei Pan Yi Sun Linbo Wang Sufan Wu Yong He Ji Wang 3D‐Printed Breast Prosthesis that Smartly Senses and Targets Breast Cancer Relapse Advanced Science 3D‐printed prosthesis breast reconstruction drug delivery relapse treatment |
| title | 3D‐Printed Breast Prosthesis that Smartly Senses and Targets Breast Cancer Relapse |
| title_full | 3D‐Printed Breast Prosthesis that Smartly Senses and Targets Breast Cancer Relapse |
| title_fullStr | 3D‐Printed Breast Prosthesis that Smartly Senses and Targets Breast Cancer Relapse |
| title_full_unstemmed | 3D‐Printed Breast Prosthesis that Smartly Senses and Targets Breast Cancer Relapse |
| title_short | 3D‐Printed Breast Prosthesis that Smartly Senses and Targets Breast Cancer Relapse |
| title_sort | 3d printed breast prosthesis that smartly senses and targets breast cancer relapse |
| topic | 3D‐printed prosthesis breast reconstruction drug delivery relapse treatment |
| url | https://doi.org/10.1002/advs.202402345 |
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