Parvovirus RNA Processing: Compact Genomic Organization and Unique Alternative mRNA Processing Mechanisms
Parvoviruses have compact genomic organizations with overlapping open reading frames and thus utilize alternative RNA processing strategies, alternative splicing, alternative polyadenylation, and alternative translation mechanisms to generate a range of diverse proteins encoded within their genome....
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/17/7/984 |
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| author | Lisa K. Uhl Olufemi O. Fasina |
| author_facet | Lisa K. Uhl Olufemi O. Fasina |
| author_sort | Lisa K. Uhl |
| collection | DOAJ |
| description | Parvoviruses have compact genomic organizations with overlapping open reading frames and thus utilize alternative RNA processing strategies, alternative splicing, alternative polyadenylation, and alternative translation mechanisms to generate a range of diverse proteins encoded within their genome. This comprehensive review provides an update on recent insights into the diverse mRNA processing mechanisms utilized by members of the <i>Parvoviridae</i> family, with emphasis on <i>Bocaparvoviruses</i> and <i>Dependoparvoviruses</i> to expand their protein repertoire and maintain their replicative advantage in infected host cells. It highlights the role of Bocaparvovirus ancillary nonstructural protein NP1; the first parvovirus protein involved in mRNA processing, specifically alternative splicing and alternative polyadenylation. |
| format | Article |
| id | doaj-art-e5e87947aa4847bd96d42d3e295ddad9 |
| institution | DOAJ |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-e5e87947aa4847bd96d42d3e295ddad92025-08-20T02:47:09ZengMDPI AGViruses1999-49152025-07-0117798410.3390/v17070984Parvovirus RNA Processing: Compact Genomic Organization and Unique Alternative mRNA Processing MechanismsLisa K. Uhl0Olufemi O. Fasina1Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USADepartment of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USAParvoviruses have compact genomic organizations with overlapping open reading frames and thus utilize alternative RNA processing strategies, alternative splicing, alternative polyadenylation, and alternative translation mechanisms to generate a range of diverse proteins encoded within their genome. This comprehensive review provides an update on recent insights into the diverse mRNA processing mechanisms utilized by members of the <i>Parvoviridae</i> family, with emphasis on <i>Bocaparvoviruses</i> and <i>Dependoparvoviruses</i> to expand their protein repertoire and maintain their replicative advantage in infected host cells. It highlights the role of Bocaparvovirus ancillary nonstructural protein NP1; the first parvovirus protein involved in mRNA processing, specifically alternative splicing and alternative polyadenylation.https://www.mdpi.com/1999-4915/17/7/984parvovirusmRNA processingalternative splicingalternative polyadenylationalternative translation initiation |
| spellingShingle | Lisa K. Uhl Olufemi O. Fasina Parvovirus RNA Processing: Compact Genomic Organization and Unique Alternative mRNA Processing Mechanisms Viruses parvovirus mRNA processing alternative splicing alternative polyadenylation alternative translation initiation |
| title | Parvovirus RNA Processing: Compact Genomic Organization and Unique Alternative mRNA Processing Mechanisms |
| title_full | Parvovirus RNA Processing: Compact Genomic Organization and Unique Alternative mRNA Processing Mechanisms |
| title_fullStr | Parvovirus RNA Processing: Compact Genomic Organization and Unique Alternative mRNA Processing Mechanisms |
| title_full_unstemmed | Parvovirus RNA Processing: Compact Genomic Organization and Unique Alternative mRNA Processing Mechanisms |
| title_short | Parvovirus RNA Processing: Compact Genomic Organization and Unique Alternative mRNA Processing Mechanisms |
| title_sort | parvovirus rna processing compact genomic organization and unique alternative mrna processing mechanisms |
| topic | parvovirus mRNA processing alternative splicing alternative polyadenylation alternative translation initiation |
| url | https://www.mdpi.com/1999-4915/17/7/984 |
| work_keys_str_mv | AT lisakuhl parvovirusrnaprocessingcompactgenomicorganizationanduniquealternativemrnaprocessingmechanisms AT olufemiofasina parvovirusrnaprocessingcompactgenomicorganizationanduniquealternativemrnaprocessingmechanisms |