The Therapeutic Potential of Antimicrobial Peptides Isolated from the Skin Secretions of Anurans of the Genus <i>Boana</i> in the Face of the Global Antimicrobial Resistance Crisis
Microorganisms play a dual role in human health, serving as both essential allies and serious threats. Their association with infections led to the development of antimicrobials like penicillin, which revolutionized medicine. However, the emergence of antimicrobial resistance (AMR) has created a glo...
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MDPI AG
2025-06-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/17/7/312 |
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| author | Priscila Mendes Ferreira Fabiano Fagundes Moser da Silva Joyce Silva dos Santos Brunna de Oliveira Silva Carlos José Correia de Santana Osmindo Rodrigues Pires Júnior Wagner Fontes Mariana S. Castro |
| author_facet | Priscila Mendes Ferreira Fabiano Fagundes Moser da Silva Joyce Silva dos Santos Brunna de Oliveira Silva Carlos José Correia de Santana Osmindo Rodrigues Pires Júnior Wagner Fontes Mariana S. Castro |
| author_sort | Priscila Mendes Ferreira |
| collection | DOAJ |
| description | Microorganisms play a dual role in human health, serving as both essential allies and serious threats. Their association with infections led to the development of antimicrobials like penicillin, which revolutionized medicine. However, the emergence of antimicrobial resistance (AMR) has created a global health crisis, rendering many treatments ineffective due to pathogen mutations and acquired resistance mechanisms, particularly among ESKAPE pathogens. This resistance increases morbidity, mortality, and healthcare costs, exacerbated by antibiotic overuse and globalization. Biofilms and sepsis further complicate treatment. Addressing AMR requires new therapies, rational antibiotic use, and innovative approaches for drug discovery. Coordinated global action is essential to ensure future access to effective treatments. Antimicrobial peptides (AMPs) derived from <i>Boana</i> species (Anura, Hylidae) represent a promising alternative in the fight against AMR. These peptides exhibit activity against multidrug-resistant pathogens. Unlike conventional antibiotics, <i>Boana</i> peptides act through a broad mechanism that limits resistance development. Their ability to disrupt bacterial membranes and modulate immune responses makes them ideal candidates for the development of new treatments. These peptides may offer valuable alternatives for treating resistant infections and addressing the global AMR crisis. |
| format | Article |
| id | doaj-art-e5e82782911d48f4aad86d0c832b2039 |
| institution | DOAJ |
| issn | 2072-6651 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj-art-e5e82782911d48f4aad86d0c832b20392025-08-20T02:47:07ZengMDPI AGToxins2072-66512025-06-0117731210.3390/toxins17070312The Therapeutic Potential of Antimicrobial Peptides Isolated from the Skin Secretions of Anurans of the Genus <i>Boana</i> in the Face of the Global Antimicrobial Resistance CrisisPriscila Mendes Ferreira0Fabiano Fagundes Moser da Silva1Joyce Silva dos Santos2Brunna de Oliveira Silva3Carlos José Correia de Santana4Osmindo Rodrigues Pires Júnior5Wagner Fontes6Mariana S. Castro7Laboratory of Toxinology, Physiological Sciences Department, Biological Sciences Institute, University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Toxinology, Physiological Sciences Department, Biological Sciences Institute, University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Toxinology, Physiological Sciences Department, Biological Sciences Institute, University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Toxinology, Physiological Sciences Department, Biological Sciences Institute, University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Toxinology, Physiological Sciences Department, Biological Sciences Institute, University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Toxinology, Physiological Sciences Department, Biological Sciences Institute, University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Protein Chemistry and Biochemistry, Cellular Biology Department, Biological Sciences Institute, University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Toxinology, Physiological Sciences Department, Biological Sciences Institute, University of Brasilia, Brasilia 70910-900, DF, BrazilMicroorganisms play a dual role in human health, serving as both essential allies and serious threats. Their association with infections led to the development of antimicrobials like penicillin, which revolutionized medicine. However, the emergence of antimicrobial resistance (AMR) has created a global health crisis, rendering many treatments ineffective due to pathogen mutations and acquired resistance mechanisms, particularly among ESKAPE pathogens. This resistance increases morbidity, mortality, and healthcare costs, exacerbated by antibiotic overuse and globalization. Biofilms and sepsis further complicate treatment. Addressing AMR requires new therapies, rational antibiotic use, and innovative approaches for drug discovery. Coordinated global action is essential to ensure future access to effective treatments. Antimicrobial peptides (AMPs) derived from <i>Boana</i> species (Anura, Hylidae) represent a promising alternative in the fight against AMR. These peptides exhibit activity against multidrug-resistant pathogens. Unlike conventional antibiotics, <i>Boana</i> peptides act through a broad mechanism that limits resistance development. Their ability to disrupt bacterial membranes and modulate immune responses makes them ideal candidates for the development of new treatments. These peptides may offer valuable alternatives for treating resistant infections and addressing the global AMR crisis.https://www.mdpi.com/2072-6651/17/7/312Anurans<i>Boana</i>skin secretionantimicrobial resistance crisisantimicrobial peptidestherapeutic properties |
| spellingShingle | Priscila Mendes Ferreira Fabiano Fagundes Moser da Silva Joyce Silva dos Santos Brunna de Oliveira Silva Carlos José Correia de Santana Osmindo Rodrigues Pires Júnior Wagner Fontes Mariana S. Castro The Therapeutic Potential of Antimicrobial Peptides Isolated from the Skin Secretions of Anurans of the Genus <i>Boana</i> in the Face of the Global Antimicrobial Resistance Crisis Toxins Anurans <i>Boana</i> skin secretion antimicrobial resistance crisis antimicrobial peptides therapeutic properties |
| title | The Therapeutic Potential of Antimicrobial Peptides Isolated from the Skin Secretions of Anurans of the Genus <i>Boana</i> in the Face of the Global Antimicrobial Resistance Crisis |
| title_full | The Therapeutic Potential of Antimicrobial Peptides Isolated from the Skin Secretions of Anurans of the Genus <i>Boana</i> in the Face of the Global Antimicrobial Resistance Crisis |
| title_fullStr | The Therapeutic Potential of Antimicrobial Peptides Isolated from the Skin Secretions of Anurans of the Genus <i>Boana</i> in the Face of the Global Antimicrobial Resistance Crisis |
| title_full_unstemmed | The Therapeutic Potential of Antimicrobial Peptides Isolated from the Skin Secretions of Anurans of the Genus <i>Boana</i> in the Face of the Global Antimicrobial Resistance Crisis |
| title_short | The Therapeutic Potential of Antimicrobial Peptides Isolated from the Skin Secretions of Anurans of the Genus <i>Boana</i> in the Face of the Global Antimicrobial Resistance Crisis |
| title_sort | therapeutic potential of antimicrobial peptides isolated from the skin secretions of anurans of the genus i boana i in the face of the global antimicrobial resistance crisis |
| topic | Anurans <i>Boana</i> skin secretion antimicrobial resistance crisis antimicrobial peptides therapeutic properties |
| url | https://www.mdpi.com/2072-6651/17/7/312 |
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