Normative mammillary body volumes: From the neonatal period to young adult
The mammillary bodies may be small, but they have an important role in encoding complex memories. Mammillary body pathology often occurs following thiamine deficiency but there is increasing evidence that the mammillary bodies are also compromised in other neurological conditions and in younger ages...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
|
| Series: | NeuroImage: Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956022000460 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850229851585249280 |
|---|---|
| author | Seralynne D. Vann Cornel Zachiu Karlijn M.E. Meys Sara Ambrosino Sarah Durston Linda S. de Vries Floris Groenendaal Maarten H. Lequin |
| author_facet | Seralynne D. Vann Cornel Zachiu Karlijn M.E. Meys Sara Ambrosino Sarah Durston Linda S. de Vries Floris Groenendaal Maarten H. Lequin |
| author_sort | Seralynne D. Vann |
| collection | DOAJ |
| description | The mammillary bodies may be small, but they have an important role in encoding complex memories. Mammillary body pathology often occurs following thiamine deficiency but there is increasing evidence that the mammillary bodies are also compromised in other neurological conditions and in younger ages groups. For example, the mammillary bodies are frequently affected in neonates with hypoxic-ischemic encephalopathy. At present, there is no normative data for the mammillary bodies in younger groups making it difficult to identify abnormalities in neurological disorders. To address this, the present study set out to develop a normative dataset for neonates and for children to young adult. A further aim was to determine whether there were laterality or sex differences in mammillary body volumes. Mammillary body volumes were obtained from MRI scans from 506 participants across two datasets. Measures for neonates were acquired from the Developing Human Connectome Project database (156 male; 100 female); volumes for individuals aged 6–24 were acquired from the NICHE database (166 males; 84 females). Volume measurements were acquired using a semi-automated multi-atlas segmentation approach. Mammillary body volumes increased up to approximately 15 years-of-age. The left mammillary body was marginally, but significantly, larger than the right in the neonates with a similar pattern in older children/young adults. In neonates, the mammillary bodies in males were slightly bigger than females but no sex differences were present in older children/young adults. Given the increasing presentation of mammillary body pathology in neonates and children, these normative data will enable better assessment of the mammillary bodies in healthy and at-risk populations. |
| format | Article |
| id | doaj-art-e5e015529b98475d812ad45f4156fc15 |
| institution | OA Journals |
| issn | 2666-9560 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Reports |
| spelling | doaj-art-e5e015529b98475d812ad45f4156fc152025-08-20T02:04:03ZengElsevierNeuroImage: Reports2666-95602022-12-012410012210.1016/j.ynirp.2022.100122Normative mammillary body volumes: From the neonatal period to young adultSeralynne D. Vann0Cornel Zachiu1Karlijn M.E. Meys2Sara Ambrosino3Sarah Durston4Linda S. de Vries5Floris Groenendaal6Maarten H. Lequin7School of Psychology, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UKDepartment of Radiotherapy, University Medical Center Utrecht, 3584 CX, Utrecht, Utrecht, the NetherlandsDivision Imaging & Oncology, Department of Radiology & Nuclear Medicine, University Medical Center Utrecht & Princess Máxima Center for Pediatric Oncology, 3508 GA, Utrecht, the NetherlandsDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, the NetherlandsEducation Center, Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the NetherlandsDeparment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, the NetherlandsDeparment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, the NetherlandsDivision Imaging & Oncology, Department of Radiology & Nuclear Medicine, University Medical Center Utrecht & Princess Máxima Center for Pediatric Oncology, 3508 GA, Utrecht, the Netherlands; Corresponding author.The mammillary bodies may be small, but they have an important role in encoding complex memories. Mammillary body pathology often occurs following thiamine deficiency but there is increasing evidence that the mammillary bodies are also compromised in other neurological conditions and in younger ages groups. For example, the mammillary bodies are frequently affected in neonates with hypoxic-ischemic encephalopathy. At present, there is no normative data for the mammillary bodies in younger groups making it difficult to identify abnormalities in neurological disorders. To address this, the present study set out to develop a normative dataset for neonates and for children to young adult. A further aim was to determine whether there were laterality or sex differences in mammillary body volumes. Mammillary body volumes were obtained from MRI scans from 506 participants across two datasets. Measures for neonates were acquired from the Developing Human Connectome Project database (156 male; 100 female); volumes for individuals aged 6–24 were acquired from the NICHE database (166 males; 84 females). Volume measurements were acquired using a semi-automated multi-atlas segmentation approach. Mammillary body volumes increased up to approximately 15 years-of-age. The left mammillary body was marginally, but significantly, larger than the right in the neonates with a similar pattern in older children/young adults. In neonates, the mammillary bodies in males were slightly bigger than females but no sex differences were present in older children/young adults. Given the increasing presentation of mammillary body pathology in neonates and children, these normative data will enable better assessment of the mammillary bodies in healthy and at-risk populations.http://www.sciencedirect.com/science/article/pii/S2666956022000460 |
| spellingShingle | Seralynne D. Vann Cornel Zachiu Karlijn M.E. Meys Sara Ambrosino Sarah Durston Linda S. de Vries Floris Groenendaal Maarten H. Lequin Normative mammillary body volumes: From the neonatal period to young adult NeuroImage: Reports |
| title | Normative mammillary body volumes: From the neonatal period to young adult |
| title_full | Normative mammillary body volumes: From the neonatal period to young adult |
| title_fullStr | Normative mammillary body volumes: From the neonatal period to young adult |
| title_full_unstemmed | Normative mammillary body volumes: From the neonatal period to young adult |
| title_short | Normative mammillary body volumes: From the neonatal period to young adult |
| title_sort | normative mammillary body volumes from the neonatal period to young adult |
| url | http://www.sciencedirect.com/science/article/pii/S2666956022000460 |
| work_keys_str_mv | AT seralynnedvann normativemammillarybodyvolumesfromtheneonatalperiodtoyoungadult AT cornelzachiu normativemammillarybodyvolumesfromtheneonatalperiodtoyoungadult AT karlijnmemeys normativemammillarybodyvolumesfromtheneonatalperiodtoyoungadult AT saraambrosino normativemammillarybodyvolumesfromtheneonatalperiodtoyoungadult AT sarahdurston normativemammillarybodyvolumesfromtheneonatalperiodtoyoungadult AT lindasdevries normativemammillarybodyvolumesfromtheneonatalperiodtoyoungadult AT florisgroenendaal normativemammillarybodyvolumesfromtheneonatalperiodtoyoungadult AT maartenhlequin normativemammillarybodyvolumesfromtheneonatalperiodtoyoungadult |