The emerging role of cellular senescence in amyotrophic lateral sclerosis
Cellular senescence is a state of permanent cell cycle arrest and is considered a key contributor to aging and age-related diseases, including amyotrophic lateral sclerosis (ALS). The physiological processes of aging lead to a variety of molecular and cellular phenotypes, and evidence of overlap bet...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1599492/full |
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| author | Xingli Tan Naiyong Gao |
| author_facet | Xingli Tan Naiyong Gao |
| author_sort | Xingli Tan |
| collection | DOAJ |
| description | Cellular senescence is a state of permanent cell cycle arrest and is considered a key contributor to aging and age-related diseases, including amyotrophic lateral sclerosis (ALS). The physiological processes of aging lead to a variety of molecular and cellular phenotypes, and evidence of overlap between ALS and aging-related biomarkers suggests that cell type-specific senescence may be a critical factor in ALS. Senescent microglial cells, astrocytes, and neurons have been detected in ALS patients and animal models. However, while accumulating evidence suggests a potential link between cellular senescence and ALS, this connection remains not yet conclusively established. Importantly, how senescent cells may contribute to the neuropathophysiology of ALS remains largely unknown. Additionally, the growing popularity of anti-aging therapies has highlighted the potential of senescent cell clearance as a promising strategy for treating age-related diseases, including ALS. This review provides an overview of cellular senescence, discusses recent advances in understanding how senescence in different cell types influences ALS pathogenesis, and explores the potential role of anti-senescence therapies in ALS treatment. |
| format | Article |
| id | doaj-art-e5dd7d24cdc74c65a4c785cd567186f2 |
| institution | DOAJ |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-e5dd7d24cdc74c65a4c785cd567186f22025-08-20T03:16:04ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-08-011910.3389/fnins.2025.15994921599492The emerging role of cellular senescence in amyotrophic lateral sclerosisXingli Tan0Naiyong Gao1School of Basic Medicine Sciences, Shandong Second Medical University, Weifang, ChinaDepartment of Neurology, Linyi People’s Hospital, Linyi, Shandong, ChinaCellular senescence is a state of permanent cell cycle arrest and is considered a key contributor to aging and age-related diseases, including amyotrophic lateral sclerosis (ALS). The physiological processes of aging lead to a variety of molecular and cellular phenotypes, and evidence of overlap between ALS and aging-related biomarkers suggests that cell type-specific senescence may be a critical factor in ALS. Senescent microglial cells, astrocytes, and neurons have been detected in ALS patients and animal models. However, while accumulating evidence suggests a potential link between cellular senescence and ALS, this connection remains not yet conclusively established. Importantly, how senescent cells may contribute to the neuropathophysiology of ALS remains largely unknown. Additionally, the growing popularity of anti-aging therapies has highlighted the potential of senescent cell clearance as a promising strategy for treating age-related diseases, including ALS. This review provides an overview of cellular senescence, discusses recent advances in understanding how senescence in different cell types influences ALS pathogenesis, and explores the potential role of anti-senescence therapies in ALS treatment.https://www.frontiersin.org/articles/10.3389/fnins.2025.1599492/fullcellular senescenceamyotrophic lateral sclerosisaginganti-senescenceaging of motor neurons |
| spellingShingle | Xingli Tan Naiyong Gao The emerging role of cellular senescence in amyotrophic lateral sclerosis Frontiers in Neuroscience cellular senescence amyotrophic lateral sclerosis aging anti-senescence aging of motor neurons |
| title | The emerging role of cellular senescence in amyotrophic lateral sclerosis |
| title_full | The emerging role of cellular senescence in amyotrophic lateral sclerosis |
| title_fullStr | The emerging role of cellular senescence in amyotrophic lateral sclerosis |
| title_full_unstemmed | The emerging role of cellular senescence in amyotrophic lateral sclerosis |
| title_short | The emerging role of cellular senescence in amyotrophic lateral sclerosis |
| title_sort | emerging role of cellular senescence in amyotrophic lateral sclerosis |
| topic | cellular senescence amyotrophic lateral sclerosis aging anti-senescence aging of motor neurons |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1599492/full |
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