Impact of Multiple Drug Resistant Tuberculous Mycobacteria on the Outcomes of Lung Resection for Fibrous Cavernous Tuberculosis
The objective: to study the impact of multiple drug resistant tuberculosis (MDR TB) on the outcomes of comprehensive treatment with surgical resection of fibrous cavernous pulmonary tuberculosis.Subjects and Methods. A prospective retrospective cohort study was performed; 526 HIV negative patients w...
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| Language: | Russian |
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New Terra Publishing House
2023-03-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1707 |
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| author | D. E. Omelchuk D. V. Krasnov T. I. Petrenko I. A. Bolshakova A. A. Dyurlyukova |
| author_facet | D. E. Omelchuk D. V. Krasnov T. I. Petrenko I. A. Bolshakova A. A. Dyurlyukova |
| author_sort | D. E. Omelchuk |
| collection | DOAJ |
| description | The objective: to study the impact of multiple drug resistant tuberculosis (MDR TB) on the outcomes of comprehensive treatment with surgical resection of fibrous cavernous pulmonary tuberculosis.Subjects and Methods. A prospective retrospective cohort study was performed; 526 HIV negative patients with unilateral fibrous cavernous tuberculosis who underwent lung resection were enrolled in the study. Patients were divided into two groups: multiple drug resistant tuberculosis - 216 subjects, drug susceptible tuberculosis - 310 subjects. Each group was divided into three subgroups: with the low (MDR TB - 105 subjects; DS TB 221 subjects), moderate (MDR TB - 67 subjects; DS TB - 68 subjects) and high activity (MDR TB - 44 subjects; DS TB - 21 subjects) of tuberculous inflammation.Results. The chances of adverse outcomes of comprehensive treatment with surgical resections of fibrous cavernous pulmonary tuberculosis are 2.5 times higher in MDR TB Group versus DS TB Group (p < 0.001; χ2, OR = 2.5; 95% CI 1.6-3.9). At the time of the surgery, among patients with MDR TB, there were significantly more patients with moderate and high activity of tuberculous inflammation versus DS TB Group (p < 0.001; χ2). When comparing the groups of patients with a homogeneous degree of tuberculous inflammation activity, no significant impact of MDR TB on the outcomes of comprehensive treatment with resections was found. However, the course of the postoperative period differed, in MDR TB Group, pleural cavity empyema (OR = 3.1; 95% CI 1.7-5.5) and tuberculosis exacerbations (OR = 4.7; 95% - CI 2.1-10.7) were significantly more frequent compared to DS TB Group. |
| format | Article |
| id | doaj-art-e5dbe3604a3a40649f6a13d0d421c2a3 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2023-03-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-e5dbe3604a3a40649f6a13d0d421c2a32025-08-20T01:47:41ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062023-03-011011414710.58838/2075-1230-2023-101-1-41-471702Impact of Multiple Drug Resistant Tuberculous Mycobacteria on the Outcomes of Lung Resection for Fibrous Cavernous TuberculosisD. E. Omelchuk0D. V. Krasnov1T. I. Petrenko2I. A. Bolshakova3A. A. Dyurlyukova4V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of HealthNovosibirsk State Medical University, Russian Ministry of HealthNovosibirsk State Medical University, Russian Ministry of HealthV.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of HealthV.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of HealthThe objective: to study the impact of multiple drug resistant tuberculosis (MDR TB) on the outcomes of comprehensive treatment with surgical resection of fibrous cavernous pulmonary tuberculosis.Subjects and Methods. A prospective retrospective cohort study was performed; 526 HIV negative patients with unilateral fibrous cavernous tuberculosis who underwent lung resection were enrolled in the study. Patients were divided into two groups: multiple drug resistant tuberculosis - 216 subjects, drug susceptible tuberculosis - 310 subjects. Each group was divided into three subgroups: with the low (MDR TB - 105 subjects; DS TB 221 subjects), moderate (MDR TB - 67 subjects; DS TB - 68 subjects) and high activity (MDR TB - 44 subjects; DS TB - 21 subjects) of tuberculous inflammation.Results. The chances of adverse outcomes of comprehensive treatment with surgical resections of fibrous cavernous pulmonary tuberculosis are 2.5 times higher in MDR TB Group versus DS TB Group (p < 0.001; χ2, OR = 2.5; 95% CI 1.6-3.9). At the time of the surgery, among patients with MDR TB, there were significantly more patients with moderate and high activity of tuberculous inflammation versus DS TB Group (p < 0.001; χ2). When comparing the groups of patients with a homogeneous degree of tuberculous inflammation activity, no significant impact of MDR TB on the outcomes of comprehensive treatment with resections was found. However, the course of the postoperative period differed, in MDR TB Group, pleural cavity empyema (OR = 3.1; 95% CI 1.7-5.5) and tuberculosis exacerbations (OR = 4.7; 95% - CI 2.1-10.7) were significantly more frequent compared to DS TB Group.https://www.tibl-journal.com/jour/article/view/1707surgical treatmentlung resectionfibrous cavernous pulmonary tuberculosismultiple drug resistance of the causative agent |
| spellingShingle | D. E. Omelchuk D. V. Krasnov T. I. Petrenko I. A. Bolshakova A. A. Dyurlyukova Impact of Multiple Drug Resistant Tuberculous Mycobacteria on the Outcomes of Lung Resection for Fibrous Cavernous Tuberculosis Туберкулез и болезни лёгких surgical treatment lung resection fibrous cavernous pulmonary tuberculosis multiple drug resistance of the causative agent |
| title | Impact of Multiple Drug Resistant Tuberculous Mycobacteria on the Outcomes of Lung Resection for Fibrous Cavernous Tuberculosis |
| title_full | Impact of Multiple Drug Resistant Tuberculous Mycobacteria on the Outcomes of Lung Resection for Fibrous Cavernous Tuberculosis |
| title_fullStr | Impact of Multiple Drug Resistant Tuberculous Mycobacteria on the Outcomes of Lung Resection for Fibrous Cavernous Tuberculosis |
| title_full_unstemmed | Impact of Multiple Drug Resistant Tuberculous Mycobacteria on the Outcomes of Lung Resection for Fibrous Cavernous Tuberculosis |
| title_short | Impact of Multiple Drug Resistant Tuberculous Mycobacteria on the Outcomes of Lung Resection for Fibrous Cavernous Tuberculosis |
| title_sort | impact of multiple drug resistant tuberculous mycobacteria on the outcomes of lung resection for fibrous cavernous tuberculosis |
| topic | surgical treatment lung resection fibrous cavernous pulmonary tuberculosis multiple drug resistance of the causative agent |
| url | https://www.tibl-journal.com/jour/article/view/1707 |
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