The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder
Children with autism spectrum disorders (ASD), including autistic disorder, frequently suffer from comorbid sleep problems. An altered melatonin rhythm is considered to underlie the impairment in sleep onset and maintenance in ASD. We report three cases with autistic disorder in whom nocturnal sympt...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2014/561071 |
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| author | Kentaro Kawabe Fumie Horiuchi Yasunori Oka Shu-ichi Ueno |
| author_facet | Kentaro Kawabe Fumie Horiuchi Yasunori Oka Shu-ichi Ueno |
| author_sort | Kentaro Kawabe |
| collection | DOAJ |
| description | Children with autism spectrum disorders (ASD), including autistic disorder, frequently suffer from comorbid sleep problems. An altered melatonin rhythm is considered to underlie the impairment in sleep onset and maintenance in ASD. We report three cases with autistic disorder in whom nocturnal symptoms improved with ramelteon, a selective melatonin receptor agonist. Insomnia and behavior, assessed using the Clinical Global Impression-Improvement Scale, improved in two cases with 2 mg ramelteon and in the third case with 8 mg ramelteon. Our findings demonstrate that ramelteon is effective not only for insomnia, but for behavioral problems as well, in patients with autistic disorder. |
| format | Article |
| id | doaj-art-e5db1e30a58a4f0c8bfd7068648ee065 |
| institution | OA Journals |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-e5db1e30a58a4f0c8bfd7068648ee0652025-08-20T02:21:03ZengWileyCase Reports in Psychiatry2090-682X2090-68382014-01-01201410.1155/2014/561071561071The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic DisorderKentaro Kawabe0Fumie Horiuchi1Yasunori Oka2Shu-ichi Ueno3Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, JapanDepartment of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, JapanCenter for Sleep Medicine, Ehime University Hospital, Shitsukawa, Toon, Ehime 791-0295, JapanDepartment of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, JapanChildren with autism spectrum disorders (ASD), including autistic disorder, frequently suffer from comorbid sleep problems. An altered melatonin rhythm is considered to underlie the impairment in sleep onset and maintenance in ASD. We report three cases with autistic disorder in whom nocturnal symptoms improved with ramelteon, a selective melatonin receptor agonist. Insomnia and behavior, assessed using the Clinical Global Impression-Improvement Scale, improved in two cases with 2 mg ramelteon and in the third case with 8 mg ramelteon. Our findings demonstrate that ramelteon is effective not only for insomnia, but for behavioral problems as well, in patients with autistic disorder.http://dx.doi.org/10.1155/2014/561071 |
| spellingShingle | Kentaro Kawabe Fumie Horiuchi Yasunori Oka Shu-ichi Ueno The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder Case Reports in Psychiatry |
| title | The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder |
| title_full | The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder |
| title_fullStr | The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder |
| title_full_unstemmed | The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder |
| title_short | The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder |
| title_sort | melatonin receptor agonist ramelteon effectively treats insomnia and behavioral symptoms in autistic disorder |
| url | http://dx.doi.org/10.1155/2014/561071 |
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