Role of Potassium-competitive Acid Blockers in the Treatment of Gastric Acid-related Disorders
Owing to their superior pharmacokinetic and pharmacodynamic profiles, potassium-competitive acid blockers (P-CABs) score over proton pump inhibitors (PPIs) in the treatment of gastric acid-related disorders and may provide clinical benefit in the management of these conditions. Previous studies have...
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Korean College of Helicobacter and Upper Gastrointestinal Research
2023-09-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
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| Online Access: | http://www.helicojournal.org/upload/pdf/kjhugr-2023-0043.pdf |
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| author | Mun Young Cho Yu Kyung Cho |
| author_facet | Mun Young Cho Yu Kyung Cho |
| author_sort | Mun Young Cho |
| collection | DOAJ |
| description | Owing to their superior pharmacokinetic and pharmacodynamic profiles, potassium-competitive acid blockers (P-CABs) score over proton pump inhibitors (PPIs) in the treatment of gastric acid-related disorders and may provide clinical benefit in the management of these conditions. Previous studies have compared P-CABs with PPIs for treatment of gastric acid-related disorders, and current data show that P-CABs are non-inferior to PPIs in the treatment of erosive esophagitis and as maintenance therapy. P-CABs are useful for effective healing and as maintenance medications in patients with severe esophagitis. These drugs also aid with healing of peptic ulcers and artificial ulcers secondary to gastric endoscopic submucosal dissection (ESD). Few studies have discussed prevention of delayed ulcer bleeding after gastric ESD and ulcers associated with long-term nonsteroidal anti-inflammatory drug administration. Well-controlled, large-scale prospective studies are warranted in future to compare P-CABs with PPIs. |
| format | Article |
| id | doaj-art-e5d8afb3bca54c2da599d0bb768c46ad |
| institution | Kabale University |
| issn | 1738-3331 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Korean College of Helicobacter and Upper Gastrointestinal Research |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj-art-e5d8afb3bca54c2da599d0bb768c46ad2025-08-20T03:57:59ZengKorean College of Helicobacter and Upper Gastrointestinal ResearchThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312023-09-0123316717310.7704/kjhugr.2023.0043789Role of Potassium-competitive Acid Blockers in the Treatment of Gastric Acid-related DisordersMun Young Cho0Yu Kyung Cho1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, KoreaOwing to their superior pharmacokinetic and pharmacodynamic profiles, potassium-competitive acid blockers (P-CABs) score over proton pump inhibitors (PPIs) in the treatment of gastric acid-related disorders and may provide clinical benefit in the management of these conditions. Previous studies have compared P-CABs with PPIs for treatment of gastric acid-related disorders, and current data show that P-CABs are non-inferior to PPIs in the treatment of erosive esophagitis and as maintenance therapy. P-CABs are useful for effective healing and as maintenance medications in patients with severe esophagitis. These drugs also aid with healing of peptic ulcers and artificial ulcers secondary to gastric endoscopic submucosal dissection (ESD). Few studies have discussed prevention of delayed ulcer bleeding after gastric ESD and ulcers associated with long-term nonsteroidal anti-inflammatory drug administration. Well-controlled, large-scale prospective studies are warranted in future to compare P-CABs with PPIs.http://www.helicojournal.org/upload/pdf/kjhugr-2023-0043.pdfgastroesophageal refluxpeptic ulcerpotassium competitive acid blockerproton pump inhibitorstreatment |
| spellingShingle | Mun Young Cho Yu Kyung Cho Role of Potassium-competitive Acid Blockers in the Treatment of Gastric Acid-related Disorders The Korean Journal of Helicobacter and Upper Gastrointestinal Research gastroesophageal reflux peptic ulcer potassium competitive acid blocker proton pump inhibitors treatment |
| title | Role of Potassium-competitive Acid Blockers in the Treatment of Gastric Acid-related Disorders |
| title_full | Role of Potassium-competitive Acid Blockers in the Treatment of Gastric Acid-related Disorders |
| title_fullStr | Role of Potassium-competitive Acid Blockers in the Treatment of Gastric Acid-related Disorders |
| title_full_unstemmed | Role of Potassium-competitive Acid Blockers in the Treatment of Gastric Acid-related Disorders |
| title_short | Role of Potassium-competitive Acid Blockers in the Treatment of Gastric Acid-related Disorders |
| title_sort | role of potassium competitive acid blockers in the treatment of gastric acid related disorders |
| topic | gastroesophageal reflux peptic ulcer potassium competitive acid blocker proton pump inhibitors treatment |
| url | http://www.helicojournal.org/upload/pdf/kjhugr-2023-0043.pdf |
| work_keys_str_mv | AT munyoungcho roleofpotassiumcompetitiveacidblockersinthetreatmentofgastricacidrelateddisorders AT yukyungcho roleofpotassiumcompetitiveacidblockersinthetreatmentofgastricacidrelateddisorders |