INHERITANCE OF POLYMORPHIC GENOTYPES OF THE ENDOTHELIN-1 GENE AND INDICATORS OF CARDIAC AND SYSTEMIC HEMODYNAMICS IN MEN WITH ESSENTIAL HYPERTENSION, RESIDENTS OF PODILLYA
The parameters of intracardiac and systemic hemodynamics in male citizens of Podillia region in Ukraine aged 40-60 with different genotypes of the ET-1 gene were studied. The study involved 141 male citizens of Podillia region in Ukraine aged 40-60. Among them 62 men were diagnosed with uncomplicate...
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Poltava State Medical University
2017-03-01
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| Series: | Проблеми екології та медицини |
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| Online Access: | https://ecomed-journal.org/index.php/journal/article/view/55 |
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| author | H.O. Palahniuk І.P. Pashkova V.M. Zhebel |
| author_facet | H.O. Palahniuk І.P. Pashkova V.M. Zhebel |
| author_sort | H.O. Palahniuk |
| collection | DOAJ |
| description | The parameters of intracardiac and systemic hemodynamics in male citizens of Podillia region in Ukraine aged 40-60 with different genotypes of the ET-1 gene were studied. The study involved 141 male citizens of Podillia region in Ukraine aged 40-60. Among them 62 men were diagnosed with uncomplicated EH with LVH, whose average age was 49,19±0,66 and 79 healthy men whose age (49.01±0.73) did not differ from patients with uncomplicated EH with LVH and made the control group (p>0.05). Genotyping of the ET-1 gene was conducted using polymerase chain reaction. The ET-1 concentration in plasma was determined by using ELISA. It was found that Lys/Lys genotype and the Lys allele of the ET-1 gene dominate among control group and patients with uncomplicated EH and LVH. In patients with uncomplicated EH and LVH all indicators of structural-functional state of the myocardium, except the size of LA, SI, DT was significantly greater in carriers of the allele Asn, than in homozygote carriers of Lys genotype of the ET-1 gene, indicating a possible negative prognosis in these patients for the development of chronic heart failure. CHLV occurs significantly more often than EHLV in men with uncomplicated EH and LVH without dependence on the genotypes of the ET-1 gene. |
| format | Article |
| id | doaj-art-e5cf8bc323d745a5b066ff4f7485a30c |
| institution | Kabale University |
| issn | 2073-4662 2519-2302 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Poltava State Medical University |
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| series | Проблеми екології та медицини |
| spelling | doaj-art-e5cf8bc323d745a5b066ff4f7485a30c2025-08-20T03:26:20ZengPoltava State Medical UniversityПроблеми екології та медицини2073-46622519-23022017-03-01195-671055INHERITANCE OF POLYMORPHIC GENOTYPES OF THE ENDOTHELIN-1 GENE AND INDICATORS OF CARDIAC AND SYSTEMIC HEMODYNAMICS IN MEN WITH ESSENTIAL HYPERTENSION, RESIDENTS OF PODILLYAH.O. Palahniuk0І.P. Pashkova1V.M. Zhebel2Vinnytsia National Pirogov Memorial Medical UniversityVinnytsia National Pirogov Memorial Medical UniversityVinnytsia National Pirogov Memorial Medical UniversityThe parameters of intracardiac and systemic hemodynamics in male citizens of Podillia region in Ukraine aged 40-60 with different genotypes of the ET-1 gene were studied. The study involved 141 male citizens of Podillia region in Ukraine aged 40-60. Among them 62 men were diagnosed with uncomplicated EH with LVH, whose average age was 49,19±0,66 and 79 healthy men whose age (49.01±0.73) did not differ from patients with uncomplicated EH with LVH and made the control group (p>0.05). Genotyping of the ET-1 gene was conducted using polymerase chain reaction. The ET-1 concentration in plasma was determined by using ELISA. It was found that Lys/Lys genotype and the Lys allele of the ET-1 gene dominate among control group and patients with uncomplicated EH and LVH. In patients with uncomplicated EH and LVH all indicators of structural-functional state of the myocardium, except the size of LA, SI, DT was significantly greater in carriers of the allele Asn, than in homozygote carriers of Lys genotype of the ET-1 gene, indicating a possible negative prognosis in these patients for the development of chronic heart failure. CHLV occurs significantly more often than EHLV in men with uncomplicated EH and LVH without dependence on the genotypes of the ET-1 gene.https://ecomed-journal.org/index.php/journal/article/view/55essential hypertension, gene polymorphism of endothelin-1, cardiac and systemic hemodynamics, plasma concentration of endothelin-1 |
| spellingShingle | H.O. Palahniuk І.P. Pashkova V.M. Zhebel INHERITANCE OF POLYMORPHIC GENOTYPES OF THE ENDOTHELIN-1 GENE AND INDICATORS OF CARDIAC AND SYSTEMIC HEMODYNAMICS IN MEN WITH ESSENTIAL HYPERTENSION, RESIDENTS OF PODILLYA Проблеми екології та медицини essential hypertension, gene polymorphism of endothelin-1, cardiac and systemic hemodynamics, plasma concentration of endothelin-1 |
| title | INHERITANCE OF POLYMORPHIC GENOTYPES OF THE ENDOTHELIN-1 GENE AND INDICATORS OF CARDIAC AND SYSTEMIC HEMODYNAMICS IN MEN WITH ESSENTIAL HYPERTENSION, RESIDENTS OF PODILLYA |
| title_full | INHERITANCE OF POLYMORPHIC GENOTYPES OF THE ENDOTHELIN-1 GENE AND INDICATORS OF CARDIAC AND SYSTEMIC HEMODYNAMICS IN MEN WITH ESSENTIAL HYPERTENSION, RESIDENTS OF PODILLYA |
| title_fullStr | INHERITANCE OF POLYMORPHIC GENOTYPES OF THE ENDOTHELIN-1 GENE AND INDICATORS OF CARDIAC AND SYSTEMIC HEMODYNAMICS IN MEN WITH ESSENTIAL HYPERTENSION, RESIDENTS OF PODILLYA |
| title_full_unstemmed | INHERITANCE OF POLYMORPHIC GENOTYPES OF THE ENDOTHELIN-1 GENE AND INDICATORS OF CARDIAC AND SYSTEMIC HEMODYNAMICS IN MEN WITH ESSENTIAL HYPERTENSION, RESIDENTS OF PODILLYA |
| title_short | INHERITANCE OF POLYMORPHIC GENOTYPES OF THE ENDOTHELIN-1 GENE AND INDICATORS OF CARDIAC AND SYSTEMIC HEMODYNAMICS IN MEN WITH ESSENTIAL HYPERTENSION, RESIDENTS OF PODILLYA |
| title_sort | inheritance of polymorphic genotypes of the endothelin 1 gene and indicators of cardiac and systemic hemodynamics in men with essential hypertension residents of podillya |
| topic | essential hypertension, gene polymorphism of endothelin-1, cardiac and systemic hemodynamics, plasma concentration of endothelin-1 |
| url | https://ecomed-journal.org/index.php/journal/article/view/55 |
| work_keys_str_mv | AT hopalahniuk inheritanceofpolymorphicgenotypesoftheendothelin1geneandindicatorsofcardiacandsystemichemodynamicsinmenwithessentialhypertensionresidentsofpodillya AT íppashkova inheritanceofpolymorphicgenotypesoftheendothelin1geneandindicatorsofcardiacandsystemichemodynamicsinmenwithessentialhypertensionresidentsofpodillya AT vmzhebel inheritanceofpolymorphicgenotypesoftheendothelin1geneandindicatorsofcardiacandsystemichemodynamicsinmenwithessentialhypertensionresidentsofpodillya |