Breast Cancer Preoperative Staging: Does Contrast-Enhanced Magnetic Resonance Mammography Modify Surgery?

Women with newly diagnosed breast cancer may have lesions undetected by conventional imaging. Recently contrast-enhanced magnetic resonance mammography (CE-MRM) showed higher sensitivity in breast lesions detection. The present analysis was aimed at evaluating the benefit of preoperative CE-MRM in t...

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Main Authors: Chiara Perono Biacchiardi, Davide Brizzi, Franco Genta, Eugenio Zanon, Marco Camanni, Francesco Deltetto
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:International Journal of Breast Cancer
Online Access:http://dx.doi.org/10.4061/2011/757234
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author Chiara Perono Biacchiardi
Davide Brizzi
Franco Genta
Eugenio Zanon
Marco Camanni
Francesco Deltetto
author_facet Chiara Perono Biacchiardi
Davide Brizzi
Franco Genta
Eugenio Zanon
Marco Camanni
Francesco Deltetto
author_sort Chiara Perono Biacchiardi
collection DOAJ
description Women with newly diagnosed breast cancer may have lesions undetected by conventional imaging. Recently contrast-enhanced magnetic resonance mammography (CE-MRM) showed higher sensitivity in breast lesions detection. The present analysis was aimed at evaluating the benefit of preoperative CE-MRM in the surgical planning. From 2005 to 2009, 525 consecutive women (25–75 years) with breast cancer, newly diagnosed by mammography, ultrasound, and needle-biopsy, underwent CE-MRM. The median invasive tumour size was 19 mm. In 144 patients, CE-MRM identified additional lesions. After secondlook, 119 patients underwent additional biopsy. CE-MRM altered surgery in 118 patients: 57 received double lumpectomy or wider excision (41 beneficial), 41 required mastectomy (40 beneficial), and 20 underwent contra lateral surgery (18 beneficial). The overall false-positive rate was 27.1% (39/144). CE-MRM contributed significantly to the management of breast cancer, suggesting more extensive disease in 144/525 (27.4%) patients and changing the surgical plan in 118/525 (22.5%) patients (99/525, 18.8% beneficial).
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series International Journal of Breast Cancer
spelling doaj-art-e5cd7efa205340f5a67a6d5eb475f5bc2025-02-03T06:11:47ZengWileyInternational Journal of Breast Cancer2090-31892011-01-01201110.4061/2011/757234757234Breast Cancer Preoperative Staging: Does Contrast-Enhanced Magnetic Resonance Mammography Modify Surgery?Chiara Perono Biacchiardi0Davide Brizzi1Franco Genta2Eugenio Zanon3Marco Camanni4Francesco Deltetto5Ginteam, Mini-Invasive Gynaecological and Breast Surgery Unit, Evangelical Hospital, ASL TO1, Via Silvio Pellico 19, 10125 Torino, ItalyBreast Radiology Unit, Evangelical Hospital, ASL TO1, Via Silvio Pellico 19, 10125 Torino, ItalyGinteam, Mini-Invasive Gynaecological and Breast Surgery Unit, Evangelical Hospital, ASL TO1, Via Silvio Pellico 19, 10125 Torino, ItalyBreast Radiology Unit, Evangelical Hospital, ASL TO1, Via Silvio Pellico 19, 10125 Torino, ItalyGinteam, Mini-Invasive Gynaecological and Breast Surgery Unit, Evangelical Hospital, ASL TO1, Via Silvio Pellico 19, 10125 Torino, ItalyGinteam, Mini-Invasive Gynaecological and Breast Surgery Unit, Evangelical Hospital, ASL TO1, Via Silvio Pellico 19, 10125 Torino, ItalyWomen with newly diagnosed breast cancer may have lesions undetected by conventional imaging. Recently contrast-enhanced magnetic resonance mammography (CE-MRM) showed higher sensitivity in breast lesions detection. The present analysis was aimed at evaluating the benefit of preoperative CE-MRM in the surgical planning. From 2005 to 2009, 525 consecutive women (25–75 years) with breast cancer, newly diagnosed by mammography, ultrasound, and needle-biopsy, underwent CE-MRM. The median invasive tumour size was 19 mm. In 144 patients, CE-MRM identified additional lesions. After secondlook, 119 patients underwent additional biopsy. CE-MRM altered surgery in 118 patients: 57 received double lumpectomy or wider excision (41 beneficial), 41 required mastectomy (40 beneficial), and 20 underwent contra lateral surgery (18 beneficial). The overall false-positive rate was 27.1% (39/144). CE-MRM contributed significantly to the management of breast cancer, suggesting more extensive disease in 144/525 (27.4%) patients and changing the surgical plan in 118/525 (22.5%) patients (99/525, 18.8% beneficial).http://dx.doi.org/10.4061/2011/757234
spellingShingle Chiara Perono Biacchiardi
Davide Brizzi
Franco Genta
Eugenio Zanon
Marco Camanni
Francesco Deltetto
Breast Cancer Preoperative Staging: Does Contrast-Enhanced Magnetic Resonance Mammography Modify Surgery?
International Journal of Breast Cancer
title Breast Cancer Preoperative Staging: Does Contrast-Enhanced Magnetic Resonance Mammography Modify Surgery?
title_full Breast Cancer Preoperative Staging: Does Contrast-Enhanced Magnetic Resonance Mammography Modify Surgery?
title_fullStr Breast Cancer Preoperative Staging: Does Contrast-Enhanced Magnetic Resonance Mammography Modify Surgery?
title_full_unstemmed Breast Cancer Preoperative Staging: Does Contrast-Enhanced Magnetic Resonance Mammography Modify Surgery?
title_short Breast Cancer Preoperative Staging: Does Contrast-Enhanced Magnetic Resonance Mammography Modify Surgery?
title_sort breast cancer preoperative staging does contrast enhanced magnetic resonance mammography modify surgery
url http://dx.doi.org/10.4061/2011/757234
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