Effectiveness of Recombinant Human Bone Morphogenetic Protein‐2 in Socket Preservation: A Randomized Controlled Clinical and Sequential Human Histological Trial (BMP‐2 TRIAL)
ABSTRACT Objectives The aim of this study was to evaluate the effectiveness of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) coated biphasic calcium phosphate (BCP) in socket preservation in comparison to BCP. Material and Methods Patients who underwent extraction of maxillary premolars w...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Clinical and Experimental Dental Research |
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| Online Access: | https://doi.org/10.1002/cre2.70134 |
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| author | Saravanan Sampoornam Pape Reddy Delfin Lovelina Francis Harshini Thirumoorthi Rahul Manish Rathi Harjeet Singh Shaswata Karmakar Shaili Pradhan |
| author_facet | Saravanan Sampoornam Pape Reddy Delfin Lovelina Francis Harshini Thirumoorthi Rahul Manish Rathi Harjeet Singh Shaswata Karmakar Shaili Pradhan |
| author_sort | Saravanan Sampoornam Pape Reddy |
| collection | DOAJ |
| description | ABSTRACT Objectives The aim of this study was to evaluate the effectiveness of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) coated biphasic calcium phosphate (BCP) in socket preservation in comparison to BCP. Material and Methods Patients who underwent extraction of maxillary premolars were randomized to receive rhBMP‐2/BCP (n = 15) and BCP alone (n = 15). All sites were primarily closed using a pedicled connective tissue flap. Biopsy was carried out in patients at 3 (n = 10), 6 (n = 10), and 9 (n = 10) months. Results At 3 months, BMP and non‐BMP groups had 3.17% and 3.12% new bone formation, respectively, and 3.8% and 37.85% of residual grafts, respectively, and 25.86% and 25.99% connective tissue component, respectively. At 6 months, both groups revealed 67.42% and 16.55% essential bone growth, 1.74% and 3.04% of residual graft, and 1.3% and 67% connective tissue component, respectively. At 9 months, the BMP group revealed 93.6% new bone formation, 0.68% residual graft, and 1.9% connective tissue component, while the non‐BMP groups had 23.35% new bone formation, 4.45% residual graft, and 44.06% connective tissue component. Conclusion This study demonstrated that rhBMP‐2 coated BCP significantly enhanced early graft substitution in socket preservation sites compared to BCP alone. There was a significantly higher percentage of new bone formation in the rhBMP‐2/BCP group both at 6 and 9 months. Additionally, the rhBMP‐2/BCP group exhibited faster resorption of the graft material and earlier maturation of newly formed bone. These findings strongly suggest that rhBMP‐2/BCP can be an effective treatment modality for socket preservation, promoting predictable and accelerated bone regeneration. |
| format | Article |
| id | doaj-art-e5cc27b8c0484ee0ba4061ba7959f9e8 |
| institution | Kabale University |
| issn | 2057-4347 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Experimental Dental Research |
| spelling | doaj-art-e5cc27b8c0484ee0ba4061ba7959f9e82025-08-20T04:01:58ZengWileyClinical and Experimental Dental Research2057-43472025-06-01113n/an/a10.1002/cre2.70134Effectiveness of Recombinant Human Bone Morphogenetic Protein‐2 in Socket Preservation: A Randomized Controlled Clinical and Sequential Human Histological Trial (BMP‐2 TRIAL)Saravanan Sampoornam Pape Reddy0Delfin Lovelina Francis1Harshini Thirumoorthi2Rahul3Manish Rathi4Harjeet Singh5Shaswata Karmakar6Shaili Pradhan7Department of Periodontology Army Dental Centre (Research & Referral) New Delhi IndiaSaveetha Dental College & Hospitals Saveetha University, Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai Tamil Nadu IndiaArunai Medical College & Hospital Tiruvannamalai Tamil Nadu IndiaDepartment of Periodontology Army Dental Centre (Research & Referral) New Delhi IndiaDepartment of Periodontology Army Dental Centre (Research & Referral) New Delhi India3 Corps Dental Unit, Army Dental Corps Indian Army IndiaDepartment of Periodontology Manipal College of Dental Sciences, Manipal Academy of Higher Education Manipal IndiaDepartment of Periodontology & Oral Implantology Kathmandu Medical College Public Limited Kathmandu Bagmati NepalABSTRACT Objectives The aim of this study was to evaluate the effectiveness of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) coated biphasic calcium phosphate (BCP) in socket preservation in comparison to BCP. Material and Methods Patients who underwent extraction of maxillary premolars were randomized to receive rhBMP‐2/BCP (n = 15) and BCP alone (n = 15). All sites were primarily closed using a pedicled connective tissue flap. Biopsy was carried out in patients at 3 (n = 10), 6 (n = 10), and 9 (n = 10) months. Results At 3 months, BMP and non‐BMP groups had 3.17% and 3.12% new bone formation, respectively, and 3.8% and 37.85% of residual grafts, respectively, and 25.86% and 25.99% connective tissue component, respectively. At 6 months, both groups revealed 67.42% and 16.55% essential bone growth, 1.74% and 3.04% of residual graft, and 1.3% and 67% connective tissue component, respectively. At 9 months, the BMP group revealed 93.6% new bone formation, 0.68% residual graft, and 1.9% connective tissue component, while the non‐BMP groups had 23.35% new bone formation, 4.45% residual graft, and 44.06% connective tissue component. Conclusion This study demonstrated that rhBMP‐2 coated BCP significantly enhanced early graft substitution in socket preservation sites compared to BCP alone. There was a significantly higher percentage of new bone formation in the rhBMP‐2/BCP group both at 6 and 9 months. Additionally, the rhBMP‐2/BCP group exhibited faster resorption of the graft material and earlier maturation of newly formed bone. These findings strongly suggest that rhBMP‐2/BCP can be an effective treatment modality for socket preservation, promoting predictable and accelerated bone regeneration.https://doi.org/10.1002/cre2.70134bone morphogenetic protein 2bone regenerationhistological techniqueregenerationridge augmentation |
| spellingShingle | Saravanan Sampoornam Pape Reddy Delfin Lovelina Francis Harshini Thirumoorthi Rahul Manish Rathi Harjeet Singh Shaswata Karmakar Shaili Pradhan Effectiveness of Recombinant Human Bone Morphogenetic Protein‐2 in Socket Preservation: A Randomized Controlled Clinical and Sequential Human Histological Trial (BMP‐2 TRIAL) Clinical and Experimental Dental Research bone morphogenetic protein 2 bone regeneration histological technique regeneration ridge augmentation |
| title | Effectiveness of Recombinant Human Bone Morphogenetic Protein‐2 in Socket Preservation: A Randomized Controlled Clinical and Sequential Human Histological Trial (BMP‐2 TRIAL) |
| title_full | Effectiveness of Recombinant Human Bone Morphogenetic Protein‐2 in Socket Preservation: A Randomized Controlled Clinical and Sequential Human Histological Trial (BMP‐2 TRIAL) |
| title_fullStr | Effectiveness of Recombinant Human Bone Morphogenetic Protein‐2 in Socket Preservation: A Randomized Controlled Clinical and Sequential Human Histological Trial (BMP‐2 TRIAL) |
| title_full_unstemmed | Effectiveness of Recombinant Human Bone Morphogenetic Protein‐2 in Socket Preservation: A Randomized Controlled Clinical and Sequential Human Histological Trial (BMP‐2 TRIAL) |
| title_short | Effectiveness of Recombinant Human Bone Morphogenetic Protein‐2 in Socket Preservation: A Randomized Controlled Clinical and Sequential Human Histological Trial (BMP‐2 TRIAL) |
| title_sort | effectiveness of recombinant human bone morphogenetic protein 2 in socket preservation a randomized controlled clinical and sequential human histological trial bmp 2 trial |
| topic | bone morphogenetic protein 2 bone regeneration histological technique regeneration ridge augmentation |
| url | https://doi.org/10.1002/cre2.70134 |
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