Testosterone therapy for hypoactive sexual desire disorder in women
Introduction and Purpose: Testosterone plays a pivotal role in women’s sexual health, influencing sexual desire, arousal, and satisfaction. This hormone, primarily produced in the ovaries, adrenal glands, and adipose tissue, declines with age, especially during menopause, leading to sexual dysfunct...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-05-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/58680 |
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| author | Jagoda Misiuk Misiuk Karolina Kopeć Aleksandra Bartoszek Julia Adamiuk Agnieszka Marut Marta Biskup Adriana Skuba Katarzyna Załuska Sylwia Nykiel Agnieszka Świdniak |
| author_facet | Jagoda Misiuk Misiuk Karolina Kopeć Aleksandra Bartoszek Julia Adamiuk Agnieszka Marut Marta Biskup Adriana Skuba Katarzyna Załuska Sylwia Nykiel Agnieszka Świdniak |
| author_sort | Jagoda Misiuk Misiuk |
| collection | DOAJ |
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Introduction and Purpose: Testosterone plays a pivotal role in women’s sexual health, influencing sexual desire, arousal, and satisfaction. This hormone, primarily produced in the ovaries, adrenal glands, and adipose tissue, declines with age, especially during menopause, leading to sexual dysfunction such as hypoactive sexual desire disorder (HSDD). The purpose of this article is to review the role of testosterone in female sexual function, evaluate the efficacy and safety of testosterone therapy (TRT) for women with HSDD, and discuss the ongoing challenges in its use.
Materials and Methods:The article is a comprehensive review of current literature, including clinical studies and trials involving testosterone therapy in women with low libido, especially in postmenopausal women. It highlights the various forms of testosterone supplementation, such as transdermal patches and topical gels, as well as monitoring recommendations for assessing testosterone levels and side effects during treatment.
Results: Testosterone therapy has shown promising results in improving sexual desire, arousal, and satisfaction in women, particularly those postmenopausal or following surgical castration. While the therapy is generally well-tolerated, common side effects include acne, hirsutism, and voice deepening. The optimal dosing regimen and long-term safety, especially in premenopausal women, remain unclear, with ongoing studies indicating positive short-term outcomes. Clinical guidelines recommend individualized treatment.
Conclusion:Testosterone replacement therapy is a viable option for women with HSDD, particularly in those with diminished testosterone levels due to menopause or surgical intervention. While promising, careful management is essential to mitigate side effects and ensure patient safety. Continued research is necessary to establish standardized treatment protocols and to further assess the long-term effects of testosterone therapy on women’s sexual health.
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| format | Article |
| id | doaj-art-e5ca64278d5740ce9386db51b774282d |
| institution | OA Journals |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-e5ca64278d5740ce9386db51b774282d2025-08-20T01:47:40ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-05-014110.12775/QS.2025.41.58680Testosterone therapy for hypoactive sexual desire disorder in womenJagoda Misiuk Misiuk0https://orcid.org/0009-0002-6227-7155Karolina Kopeć1https://orcid.org/0009-0001-1257-7865Aleksandra Bartoszek2https://orcid.org/0009-0008-2071-3821Julia Adamiuk3https://orcid.org/0009-0003-5857-7646Agnieszka Marut4https://orcid.org/0009-0005-4884-7854Marta Biskup5https://orcid.org/0009-0001-8760-2930Adriana Skuba6https://orcid.org/0009-0002-1474-8039Katarzyna Załuska7https://orcid.org/0009-0000-3189-5925Sylwia Nykiel8https://orcid.org/0009-0007-6967-8927Agnieszka Świdniak9https://orcid.org/0009-0005-4336-188XUniversity of RzeszówUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, Poland Introduction and Purpose: Testosterone plays a pivotal role in women’s sexual health, influencing sexual desire, arousal, and satisfaction. This hormone, primarily produced in the ovaries, adrenal glands, and adipose tissue, declines with age, especially during menopause, leading to sexual dysfunction such as hypoactive sexual desire disorder (HSDD). The purpose of this article is to review the role of testosterone in female sexual function, evaluate the efficacy and safety of testosterone therapy (TRT) for women with HSDD, and discuss the ongoing challenges in its use. Materials and Methods:The article is a comprehensive review of current literature, including clinical studies and trials involving testosterone therapy in women with low libido, especially in postmenopausal women. It highlights the various forms of testosterone supplementation, such as transdermal patches and topical gels, as well as monitoring recommendations for assessing testosterone levels and side effects during treatment. Results: Testosterone therapy has shown promising results in improving sexual desire, arousal, and satisfaction in women, particularly those postmenopausal or following surgical castration. While the therapy is generally well-tolerated, common side effects include acne, hirsutism, and voice deepening. The optimal dosing regimen and long-term safety, especially in premenopausal women, remain unclear, with ongoing studies indicating positive short-term outcomes. Clinical guidelines recommend individualized treatment. Conclusion:Testosterone replacement therapy is a viable option for women with HSDD, particularly in those with diminished testosterone levels due to menopause or surgical intervention. While promising, careful management is essential to mitigate side effects and ensure patient safety. Continued research is necessary to establish standardized treatment protocols and to further assess the long-term effects of testosterone therapy on women’s sexual health. https://apcz.umk.pl/QS/article/view/58680systemic testosteronehypoactive sexual desire disorderfemale sexual dysfunctionISSWSHtestosterone therapymenopause |
| spellingShingle | Jagoda Misiuk Misiuk Karolina Kopeć Aleksandra Bartoszek Julia Adamiuk Agnieszka Marut Marta Biskup Adriana Skuba Katarzyna Załuska Sylwia Nykiel Agnieszka Świdniak Testosterone therapy for hypoactive sexual desire disorder in women Quality in Sport systemic testosterone hypoactive sexual desire disorder female sexual dysfunction ISSWSH testosterone therapy menopause |
| title | Testosterone therapy for hypoactive sexual desire disorder in women |
| title_full | Testosterone therapy for hypoactive sexual desire disorder in women |
| title_fullStr | Testosterone therapy for hypoactive sexual desire disorder in women |
| title_full_unstemmed | Testosterone therapy for hypoactive sexual desire disorder in women |
| title_short | Testosterone therapy for hypoactive sexual desire disorder in women |
| title_sort | testosterone therapy for hypoactive sexual desire disorder in women |
| topic | systemic testosterone hypoactive sexual desire disorder female sexual dysfunction ISSWSH testosterone therapy menopause |
| url | https://apcz.umk.pl/QS/article/view/58680 |
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