Impact of SARS-CoV-2 (COVID-19) on pregnancy: a systematic review and meta-analysis protocol
Introduction The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has been growing at an accelerating rate, and has become a public health emergency. Pregnant women and their fetuses are susceptible to viral infection, and outcomes in this population need to be investigated.Methods and analysis Pu...
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BMJ Publishing Group
2020-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/11/e039933.full |
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| author | Ayane Cristine Alves Sarmento Ana Paula Ferreira Costa Ana Katherine Gonçalves Kleyton Santos Medeiros Erico Silva Martins José Eleutério Jr |
| author_facet | Ayane Cristine Alves Sarmento Ana Paula Ferreira Costa Ana Katherine Gonçalves Kleyton Santos Medeiros Erico Silva Martins José Eleutério Jr |
| author_sort | Ayane Cristine Alves Sarmento |
| collection | DOAJ |
| description | Introduction The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has been growing at an accelerating rate, and has become a public health emergency. Pregnant women and their fetuses are susceptible to viral infection, and outcomes in this population need to be investigated.Methods and analysis PubMed, Web of Science, Embase, CINAHAL, Latin American and Caribbean Health Sciences Literature, clinicaltrials.gov, SCOPUS, Google Scholar and Cochrane Central Controlled Trials Registry will be searched for observational studies (cohort and control cases) published from December 2019 to present. This systematic review and meta-analysis will include studies of pregnant women at any gestational stage diagnosed with COVID-19. The primary outcomes will be maternal and foetal morbidity and mortality. Three independent reviewers will select the studies and extract data from the original publications. The risk of bias will be assessed using the Newcastle-Ottawa Scale for observational studies. To evaluate the strength of evidence from the included data, we will use Grading of Recommendation Assessment, Development, and Evaluation method. Data synthesis will be performed using Review Manager software V.5.2.3. To assess heterogeneity, we will compute the I2 statistics. Additionally, a quantitative synthesis will be performed if the included studies are sufficiently homogenous.Ethics and dissemination This study will be a review of the published data, and thus it is not necessary to obtain ethical approval. The findings of this systematic review will be published in a peer-reviewed journal.PROSPERO registration number PROSPERO 2020: CRD42020181519. |
| format | Article |
| id | doaj-art-e5c9324603334d9aa118c9bc6b370614 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-e5c9324603334d9aa118c9bc6b3706142025-08-20T02:01:57ZengBMJ Publishing GroupBMJ Open2044-60552020-11-01101110.1136/bmjopen-2020-039933Impact of SARS-CoV-2 (COVID-19) on pregnancy: a systematic review and meta-analysis protocolAyane Cristine Alves Sarmento0Ana Paula Ferreira Costa1Ana Katherine Gonçalves2Kleyton Santos Medeiros3Erico Silva Martins4José Eleutério Jr52 Department of Clinical Analysis and Toxicology, Universidade Federal do Rio Grande do Norte, Natal, BrazilPostgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil3 Universidade Federal do Rio Grande do Norte, Natal, Brazil4 Institute of Teaching, Research and Innovation, League Against Cancer, Natal, BrazilOncology School, Liga Norte Riograndense Contra o Câncer, Natal, Rio Grande do Norte, BrazilMotherhood and Child Department, Universidade Federal do Ceara, Fortaleza, BrazilIntroduction The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has been growing at an accelerating rate, and has become a public health emergency. Pregnant women and their fetuses are susceptible to viral infection, and outcomes in this population need to be investigated.Methods and analysis PubMed, Web of Science, Embase, CINAHAL, Latin American and Caribbean Health Sciences Literature, clinicaltrials.gov, SCOPUS, Google Scholar and Cochrane Central Controlled Trials Registry will be searched for observational studies (cohort and control cases) published from December 2019 to present. This systematic review and meta-analysis will include studies of pregnant women at any gestational stage diagnosed with COVID-19. The primary outcomes will be maternal and foetal morbidity and mortality. Three independent reviewers will select the studies and extract data from the original publications. The risk of bias will be assessed using the Newcastle-Ottawa Scale for observational studies. To evaluate the strength of evidence from the included data, we will use Grading of Recommendation Assessment, Development, and Evaluation method. Data synthesis will be performed using Review Manager software V.5.2.3. To assess heterogeneity, we will compute the I2 statistics. Additionally, a quantitative synthesis will be performed if the included studies are sufficiently homogenous.Ethics and dissemination This study will be a review of the published data, and thus it is not necessary to obtain ethical approval. The findings of this systematic review will be published in a peer-reviewed journal.PROSPERO registration number PROSPERO 2020: CRD42020181519.https://bmjopen.bmj.com/content/10/11/e039933.full |
| spellingShingle | Ayane Cristine Alves Sarmento Ana Paula Ferreira Costa Ana Katherine Gonçalves Kleyton Santos Medeiros Erico Silva Martins José Eleutério Jr Impact of SARS-CoV-2 (COVID-19) on pregnancy: a systematic review and meta-analysis protocol BMJ Open |
| title | Impact of SARS-CoV-2 (COVID-19) on pregnancy: a systematic review and meta-analysis protocol |
| title_full | Impact of SARS-CoV-2 (COVID-19) on pregnancy: a systematic review and meta-analysis protocol |
| title_fullStr | Impact of SARS-CoV-2 (COVID-19) on pregnancy: a systematic review and meta-analysis protocol |
| title_full_unstemmed | Impact of SARS-CoV-2 (COVID-19) on pregnancy: a systematic review and meta-analysis protocol |
| title_short | Impact of SARS-CoV-2 (COVID-19) on pregnancy: a systematic review and meta-analysis protocol |
| title_sort | impact of sars cov 2 covid 19 on pregnancy a systematic review and meta analysis protocol |
| url | https://bmjopen.bmj.com/content/10/11/e039933.full |
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