A comprehensive analysis identifies and validates NPC1 as a potential biomarker for prognosis in HCC

A comprehensive analysis identifies and validates NPC1 as a potential biomarker for prognosis in HCC

Niemann-Pick type C1 protein (NPC1), a key regulator of intracellular cholesterol transport and a transmembrane protein, has been implicated in carcinogenesis, particularly in hepatocellular carcinoma (HCC). Despite the noted association, the specific role of NPC1 in HCC remains underexplored. In th...

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Bibliographic Details
Main Authors: Xingjun Lu, Tianyao Gou, Xuxing He, Xia Chen, Daqing Yang, Xiaozhen Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Genetics
Subjects:
NPC1
prognosis
biomarker
HCC
therapeutic target
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1588583/full
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