Prognostic Value of the Brixia Radiological Score in COVID-19 Patients: A Retrospective Study from Romania
The novel coronavirus pandemic, SARS-CoV-2, has a variable clinical spectrum, ranging from asymptomatic to critical forms. High mortality and morbidity rates have been associated with risk factors such as comorbidities, age, sex, and virulence factors specific to viral variants. Material and Methods...
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MDPI AG
2025-05-01
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| author | George-Cosmin Popovici Costinela-Valerica Georgescu Alina Condratovici Plesea Anca-Adriana Arbune Gutu Cristian Manuela Arbune |
| author_facet | George-Cosmin Popovici Costinela-Valerica Georgescu Alina Condratovici Plesea Anca-Adriana Arbune Gutu Cristian Manuela Arbune |
| author_sort | George-Cosmin Popovici |
| collection | DOAJ |
| description | The novel coronavirus pandemic, SARS-CoV-2, has a variable clinical spectrum, ranging from asymptomatic to critical forms. High mortality and morbidity rates have been associated with risk factors such as comorbidities, age, sex, and virulence factors specific to viral variants. Material and Methods: We retrospectively evaluated imaging characteristics using the Brixia radiological score in relation to favorable or unfavorable outcomes in adult patients. We included COVID-19 cases, admitted between 2020 and 2022, in a specialized pulmonology hospital with no intensive care unit. We analyzed 380 virologically confirmed COVID-19 cases, with a mean age of 52.8 ± 13.02 years. The mean Brixia radiological score at admission was 5.13 ± 3.56, reflecting predominantly mild-to-moderate pulmonary involvement. Multivariate analysis highlighted the utility of this score as a predictive marker for COVID-19 prognosis, with values >5 correlating with other severity biomarkers, NEWS-2 scores, and a lack of vaccination and hospitalization delay of more than 6 days from symptom onset. Summarizing, the Brixia score is itself an effective tool for screening COVID-19 cases at risk of death for early recognition of clinical deterioration and for decisions regarding appropriate care settings. Promoting vaccination can reduce the severity of radiological lesions, thereby decreasing the risk of death. Technologies based on artificial intelligence could optimize diagnosis and management decisions. |
| format | Article |
| id | doaj-art-e5c8be03d3dc442986b040e0d39a6615 |
| institution | DOAJ |
| issn | 2414-6366 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Tropical Medicine and Infectious Disease |
| spelling | doaj-art-e5c8be03d3dc442986b040e0d39a66152025-08-20T03:12:09ZengMDPI AGTropical Medicine and Infectious Disease2414-63662025-05-0110513010.3390/tropicalmed10050130Prognostic Value of the Brixia Radiological Score in COVID-19 Patients: A Retrospective Study from RomaniaGeorge-Cosmin Popovici0Costinela-Valerica Georgescu1Alina Condratovici Plesea2Anca-Adriana Arbune3Gutu Cristian4Manuela Arbune5School for Doctoral Studies in Biomedical Sciences, “Dunarea de Jos” University from Galati, 800008 Galati, RomaniaPharmaceutical Sciences Department, “Dunarea de Jos” University from Galati, 800008 Galati, RomaniaMedical Department, “Dunarea de Jos” University from Galati, 800008 Galati, RomaniaNeurology Department Clinic Institute Fundeni Bucharest, 022328 Bucharest, Romania“Dr. Aristide Serfioti” Military Emergency Hospital, 800008 Galati, RomaniaMedical Clinic Department, “Dunarea de Jos” University from Galati, 800008 Galati, RomaniaThe novel coronavirus pandemic, SARS-CoV-2, has a variable clinical spectrum, ranging from asymptomatic to critical forms. High mortality and morbidity rates have been associated with risk factors such as comorbidities, age, sex, and virulence factors specific to viral variants. Material and Methods: We retrospectively evaluated imaging characteristics using the Brixia radiological score in relation to favorable or unfavorable outcomes in adult patients. We included COVID-19 cases, admitted between 2020 and 2022, in a specialized pulmonology hospital with no intensive care unit. We analyzed 380 virologically confirmed COVID-19 cases, with a mean age of 52.8 ± 13.02 years. The mean Brixia radiological score at admission was 5.13 ± 3.56, reflecting predominantly mild-to-moderate pulmonary involvement. Multivariate analysis highlighted the utility of this score as a predictive marker for COVID-19 prognosis, with values >5 correlating with other severity biomarkers, NEWS-2 scores, and a lack of vaccination and hospitalization delay of more than 6 days from symptom onset. Summarizing, the Brixia score is itself an effective tool for screening COVID-19 cases at risk of death for early recognition of clinical deterioration and for decisions regarding appropriate care settings. Promoting vaccination can reduce the severity of radiological lesions, thereby decreasing the risk of death. Technologies based on artificial intelligence could optimize diagnosis and management decisions.https://www.mdpi.com/2414-6366/10/5/130COVID-19Brixia scorepredictor deathemerging infectious disease |
| spellingShingle | George-Cosmin Popovici Costinela-Valerica Georgescu Alina Condratovici Plesea Anca-Adriana Arbune Gutu Cristian Manuela Arbune Prognostic Value of the Brixia Radiological Score in COVID-19 Patients: A Retrospective Study from Romania Tropical Medicine and Infectious Disease COVID-19 Brixia score predictor death emerging infectious disease |
| title | Prognostic Value of the Brixia Radiological Score in COVID-19 Patients: A Retrospective Study from Romania |
| title_full | Prognostic Value of the Brixia Radiological Score in COVID-19 Patients: A Retrospective Study from Romania |
| title_fullStr | Prognostic Value of the Brixia Radiological Score in COVID-19 Patients: A Retrospective Study from Romania |
| title_full_unstemmed | Prognostic Value of the Brixia Radiological Score in COVID-19 Patients: A Retrospective Study from Romania |
| title_short | Prognostic Value of the Brixia Radiological Score in COVID-19 Patients: A Retrospective Study from Romania |
| title_sort | prognostic value of the brixia radiological score in covid 19 patients a retrospective study from romania |
| topic | COVID-19 Brixia score predictor death emerging infectious disease |
| url | https://www.mdpi.com/2414-6366/10/5/130 |
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