The Role of Skin Dysbiosis and Quorum Sensing in Atopic Dermatitis
The skin microbiome plays a crucial role in the pathogenesis of atopic dermatitis (AD), a chronic inflammatory skin disorder strongly associated with microbial dysbiosis, particularly Staphylococcus aureus colonization. However, the mechanisms linking S aureus to AD remain insufficiently understood....
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| Language: | English |
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Elsevier
2025-07-01
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| Series: | JID Innovations |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667026725000335 |
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| author | Hiroki Okamoto Shuo Li Yuumi Nakamura |
| author_facet | Hiroki Okamoto Shuo Li Yuumi Nakamura |
| author_sort | Hiroki Okamoto |
| collection | DOAJ |
| description | The skin microbiome plays a crucial role in the pathogenesis of atopic dermatitis (AD), a chronic inflammatory skin disorder strongly associated with microbial dysbiosis, particularly Staphylococcus aureus colonization. However, the mechanisms linking S aureus to AD remain insufficiently understood. This review explores the impact of the quorum-sensing (QS) system, particularly the accessory gene regulator Agr, in AD development and progression. By examining key microbial–host interactions, we provide insights into how QS influences skin inflammation and dysbiosis. Furthermore, we discuss the potential of microbiome-targeted therapeutic strategies to mitigate or prevent AD, highlighting their implications for future research and clinical applications. |
| format | Article |
| id | doaj-art-e5c88c71c31f470db807299b7110d8f7 |
| institution | Kabale University |
| issn | 2667-0267 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JID Innovations |
| spelling | doaj-art-e5c88c71c31f470db807299b7110d8f72025-08-20T03:50:22ZengElsevierJID Innovations2667-02672025-07-015410037710.1016/j.xjidi.2025.100377The Role of Skin Dysbiosis and Quorum Sensing in Atopic DermatitisHiroki Okamoto0Shuo Li1Yuumi Nakamura2Department of Dermatology, The University of Osaka Graduate School of Medicine, Osaka, JapanCutaneous Allergy and Host Defense, Immunology Frontier Research Center, The University of Osaka, Osaka, JapanDepartment of Dermatology, The University of Osaka Graduate School of Medicine, Osaka, Japan; Cutaneous Allergy and Host Defense, Immunology Frontier Research Center, The University of Osaka, Osaka, Japan; Correspondence: Yuumi Nakamura, Cutaneous Allergy and Host Defense, Immunology Frontier Research Center, The University of Osaka, 3-1, Yamadaoka, Suita, Osaka 565-0871, Japan.The skin microbiome plays a crucial role in the pathogenesis of atopic dermatitis (AD), a chronic inflammatory skin disorder strongly associated with microbial dysbiosis, particularly Staphylococcus aureus colonization. However, the mechanisms linking S aureus to AD remain insufficiently understood. This review explores the impact of the quorum-sensing (QS) system, particularly the accessory gene regulator Agr, in AD development and progression. By examining key microbial–host interactions, we provide insights into how QS influences skin inflammation and dysbiosis. Furthermore, we discuss the potential of microbiome-targeted therapeutic strategies to mitigate or prevent AD, highlighting their implications for future research and clinical applications.http://www.sciencedirect.com/science/article/pii/S2667026725000335Atopic dermatitisSkin microbiomeStaphylococcus aureusQuorum sensing |
| spellingShingle | Hiroki Okamoto Shuo Li Yuumi Nakamura The Role of Skin Dysbiosis and Quorum Sensing in Atopic Dermatitis JID Innovations Atopic dermatitis Skin microbiome Staphylococcus aureus Quorum sensing |
| title | The Role of Skin Dysbiosis and Quorum Sensing in Atopic Dermatitis |
| title_full | The Role of Skin Dysbiosis and Quorum Sensing in Atopic Dermatitis |
| title_fullStr | The Role of Skin Dysbiosis and Quorum Sensing in Atopic Dermatitis |
| title_full_unstemmed | The Role of Skin Dysbiosis and Quorum Sensing in Atopic Dermatitis |
| title_short | The Role of Skin Dysbiosis and Quorum Sensing in Atopic Dermatitis |
| title_sort | role of skin dysbiosis and quorum sensing in atopic dermatitis |
| topic | Atopic dermatitis Skin microbiome Staphylococcus aureus Quorum sensing |
| url | http://www.sciencedirect.com/science/article/pii/S2667026725000335 |
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