Inflammation Factors Mediate Association of Muscle Mass and Migraine: NHANES 1999–2004 and Mendelian Randomization
Chunyan Jia, Hong Li, Shaonan Yang, Yue Liu, Lijun Liu, Aijun Ma, Liang Zhang Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, People’s Republic of ChinaCorrespondence: Liang Zhang, Department of Neurology, The Affiliated Hospital of Qingdao Univer...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-05-01
|
| Series: | Journal of Pain Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/inflammation-factors-mediate-association-of-muscle-mass-and-migraine-n-peer-reviewed-fulltext-article-JPR |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849728516627628032 |
|---|---|
| author | Jia C Li H Yang S Liu Y Liu L Ma A Zhang L |
| author_facet | Jia C Li H Yang S Liu Y Liu L Ma A Zhang L |
| author_sort | Jia C |
| collection | DOAJ |
| description | Chunyan Jia, Hong Li, Shaonan Yang, Yue Liu, Lijun Liu, Aijun Ma, Liang Zhang Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, People’s Republic of ChinaCorrespondence: Liang Zhang, Department of Neurology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Shinan District, Qingdao, Shandong, 266071, People’s Republic of China, Tel +86-178-5329-7291, Email drzhangliang@126.com Lijun Liu, Department of Neurology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Shinan District, Qingdao, Shandong, 266071, People’s Republic of China, Tel +86-178-5329-0950, Email superdrjenny@126.comPurpose: The relationship between adipose-muscle distribution and its effect on migraine remains unclear. This study examines the association between muscle mass and migraine prevalence and evaluates potential mediation by systemic inflammatory biomarkers.Methods: Using a cross-sectional design, we analyzed data from 10,400 participants in the National Health and Nutrition Examination Survey (NHANES) (1999– 2004). The association between appendicular lean mass normalized to body mass index (ALM/BMI) and migraine prevalence was evaluated through weighted logistic regression and subgroup analyses. Mediation analyses were conducted to examine the potential mediating roles of inflammatory markers, including C-reactive protein (CRP), white blood cell count (WBC), and neutrophils, in the relationship between ALM/BMI and migraine prevalence. Genetic causality was investigated via two-sample Mendelian randomization (MR) using genome-wide association study (GWAS) data.Results: 20% of total participants reported migraines. A higher ALM/BMI ratio was inversely associated with migraine after full adjustment (OR = 0.243; 95% CI: 0.122– 0.487, p < 0.001). Vigorous activity reduced migraine susceptibility by 24% (OR = 0.760; 95% CI: 0.663– 0.872, p < 0.001). CRP, WBC and neutrophils mediated 2.0% (p = 0.024), 3.1% (p = 0.011), and 2.8% (p = 0.019) of the ALM/BMI-migraine association, respectively. The inverse-variance weighted approach (IVW) in MR analysis indicated that higher basal metabolic rate (BMR) reduced migraine risk (OR = 0.996, 95% CI: 0.992– 0.998, p = 0.004) and headache risk (OR = 0.998, 95% CI: 0.997– 1.000, p = 0.018). Fat-free mass also exhibited protective effects on migraines (OR = 0.997, 95% CI: 0.994– 1.000, p = 0.045).Conclusion: Increased muscle mass is associated with reduced migraine risk, partially mediated by attenuating systemic inflammation. These findings provide us with an approach of health management to prevent migraines.Keywords: appendicular muscle mass, basal metabolic rate, migraine, inflammation, national health and nutrition examination survey, Mendelian randomization |
| format | Article |
| id | doaj-art-e5c6490aa6eb49569347324b14d6df33 |
| institution | DOAJ |
| issn | 1178-7090 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj-art-e5c6490aa6eb49569347324b14d6df332025-08-20T03:09:32ZengDove Medical PressJournal of Pain Research1178-70902025-05-01Volume 18Issue 122692283102618Inflammation Factors Mediate Association of Muscle Mass and Migraine: NHANES 1999&ndash;2004 and Mendelian RandomizationJia C0Li H1Yang SLiu Y2Liu LMa A3Zhang L4Department of NeurologyDepartment of NeurologyneurologyDepartment of NeurologyDepartment of NeurologyChunyan Jia, Hong Li, Shaonan Yang, Yue Liu, Lijun Liu, Aijun Ma, Liang Zhang Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, People’s Republic of ChinaCorrespondence: Liang Zhang, Department of Neurology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Shinan District, Qingdao, Shandong, 266071, People’s Republic of China, Tel +86-178-5329-7291, Email drzhangliang@126.com Lijun Liu, Department of Neurology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Shinan District, Qingdao, Shandong, 266071, People’s Republic of China, Tel +86-178-5329-0950, Email superdrjenny@126.comPurpose: The relationship between adipose-muscle distribution and its effect on migraine remains unclear. This study examines the association between muscle mass and migraine prevalence and evaluates potential mediation by systemic inflammatory biomarkers.Methods: Using a cross-sectional design, we analyzed data from 10,400 participants in the National Health and Nutrition Examination Survey (NHANES) (1999– 2004). The association between appendicular lean mass normalized to body mass index (ALM/BMI) and migraine prevalence was evaluated through weighted logistic regression and subgroup analyses. Mediation analyses were conducted to examine the potential mediating roles of inflammatory markers, including C-reactive protein (CRP), white blood cell count (WBC), and neutrophils, in the relationship between ALM/BMI and migraine prevalence. Genetic causality was investigated via two-sample Mendelian randomization (MR) using genome-wide association study (GWAS) data.Results: 20% of total participants reported migraines. A higher ALM/BMI ratio was inversely associated with migraine after full adjustment (OR = 0.243; 95% CI: 0.122– 0.487, p < 0.001). Vigorous activity reduced migraine susceptibility by 24% (OR = 0.760; 95% CI: 0.663– 0.872, p < 0.001). CRP, WBC and neutrophils mediated 2.0% (p = 0.024), 3.1% (p = 0.011), and 2.8% (p = 0.019) of the ALM/BMI-migraine association, respectively. The inverse-variance weighted approach (IVW) in MR analysis indicated that higher basal metabolic rate (BMR) reduced migraine risk (OR = 0.996, 95% CI: 0.992– 0.998, p = 0.004) and headache risk (OR = 0.998, 95% CI: 0.997– 1.000, p = 0.018). Fat-free mass also exhibited protective effects on migraines (OR = 0.997, 95% CI: 0.994– 1.000, p = 0.045).Conclusion: Increased muscle mass is associated with reduced migraine risk, partially mediated by attenuating systemic inflammation. These findings provide us with an approach of health management to prevent migraines.Keywords: appendicular muscle mass, basal metabolic rate, migraine, inflammation, national health and nutrition examination survey, Mendelian randomizationhttps://www.dovepress.com/inflammation-factors-mediate-association-of-muscle-mass-and-migraine-n-peer-reviewed-fulltext-article-JPRAppendicular muscle massbasal metabolic ratemigraineinflammationnational health and nutrition examination surveyMendelian randomization |
| spellingShingle | Jia C Li H Yang S Liu Y Liu L Ma A Zhang L Inflammation Factors Mediate Association of Muscle Mass and Migraine: NHANES 1999&ndash;2004 and Mendelian Randomization Journal of Pain Research Appendicular muscle mass basal metabolic rate migraine inflammation national health and nutrition examination survey Mendelian randomization |
| title | Inflammation Factors Mediate Association of Muscle Mass and Migraine: NHANES 1999&ndash;2004 and Mendelian Randomization |
| title_full | Inflammation Factors Mediate Association of Muscle Mass and Migraine: NHANES 1999&ndash;2004 and Mendelian Randomization |
| title_fullStr | Inflammation Factors Mediate Association of Muscle Mass and Migraine: NHANES 1999&ndash;2004 and Mendelian Randomization |
| title_full_unstemmed | Inflammation Factors Mediate Association of Muscle Mass and Migraine: NHANES 1999&ndash;2004 and Mendelian Randomization |
| title_short | Inflammation Factors Mediate Association of Muscle Mass and Migraine: NHANES 1999&ndash;2004 and Mendelian Randomization |
| title_sort | inflammation factors mediate association of muscle mass and migraine nhanes 1999 amp ndash 2004 and mendelian randomization |
| topic | Appendicular muscle mass basal metabolic rate migraine inflammation national health and nutrition examination survey Mendelian randomization |
| url | https://www.dovepress.com/inflammation-factors-mediate-association-of-muscle-mass-and-migraine-n-peer-reviewed-fulltext-article-JPR |
| work_keys_str_mv | AT jiac inflammationfactorsmediateassociationofmusclemassandmigrainenhanes1999ampndash2004andmendelianrandomization AT lih inflammationfactorsmediateassociationofmusclemassandmigrainenhanes1999ampndash2004andmendelianrandomization AT yangs inflammationfactorsmediateassociationofmusclemassandmigrainenhanes1999ampndash2004andmendelianrandomization AT liuy inflammationfactorsmediateassociationofmusclemassandmigrainenhanes1999ampndash2004andmendelianrandomization AT liul inflammationfactorsmediateassociationofmusclemassandmigrainenhanes1999ampndash2004andmendelianrandomization AT maa inflammationfactorsmediateassociationofmusclemassandmigrainenhanes1999ampndash2004andmendelianrandomization AT zhangl inflammationfactorsmediateassociationofmusclemassandmigrainenhanes1999ampndash2004andmendelianrandomization |