Diagnostic Methods for Feline Coronavirus: A Review
Feline coronaviruses (FCoVs) are found throughout the world. Infection with FCoV can result in a diverse range of signs from clinically inapparent infections to a highly fatal disease called feline infectious peritonitis (FIP). FIP is one of the most serious viral diseases of cats. While there is ne...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.4061/2010/809480 |
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| author | Saeed Sharif Siti Suri Arshad Mohd Hair-Bejo Abdul Rahman Omar Nazariah Allaudin Zeenathul Amer Alazawy |
| author_facet | Saeed Sharif Siti Suri Arshad Mohd Hair-Bejo Abdul Rahman Omar Nazariah Allaudin Zeenathul Amer Alazawy |
| author_sort | Saeed Sharif |
| collection | DOAJ |
| description | Feline coronaviruses (FCoVs) are found throughout the world. Infection with FCoV can result in a diverse range of signs from clinically inapparent infections to a highly fatal disease called feline infectious peritonitis (FIP). FIP is one of the most serious viral diseases of cats. While there is neither an effective vaccine, nor a curative treatment for FIP, a diagnostic protocol for FCoV would greatly assist in the management and control of the virus. Clinical findings in FIP are non-specific and not helpful in making a differential diagnosis. Haematological and biochemical abnormalities in FIP cases are also non-specific. The currently available serological tests have low specificity and sensitivity for detection of active infection and cross-react with FCoV strains of low pathogenicity, the feline enteric coronaviruses (FECV). Reverse transcriptase polymerase chain reaction (RT-PCR) has been used to detect FCoV and is rapid and sensitive, but results must be interpreted in the context of clinical findings. At present, a definitive diagnosis of FIP can be established only by histopathological examination of biopsies. This paper describes and compares diagnostic methods for FCoVs and includes a brief account of the virus biology, epidemiology, and pathogenesis. |
| format | Article |
| id | doaj-art-e5c63bdd8de3437f8acbd1184dd3a9c7 |
| institution | Kabale University |
| issn | 2042-0048 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-e5c63bdd8de3437f8acbd1184dd3a9c72025-08-20T03:26:20ZengWileyVeterinary Medicine International2042-00482010-01-01201010.4061/2010/809480809480Diagnostic Methods for Feline Coronavirus: A ReviewSaeed Sharif0Siti Suri Arshad1Mohd Hair-Bejo2Abdul Rahman Omar3Nazariah Allaudin Zeenathul4Amer Alazawy5Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor D. E. 43400, MalaysiaDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor D. E. 43400, MalaysiaDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor D. E. 43400, MalaysiaDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor D. E. 43400, MalaysiaDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor D. E. 43400, MalaysiaDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor D. E. 43400, MalaysiaFeline coronaviruses (FCoVs) are found throughout the world. Infection with FCoV can result in a diverse range of signs from clinically inapparent infections to a highly fatal disease called feline infectious peritonitis (FIP). FIP is one of the most serious viral diseases of cats. While there is neither an effective vaccine, nor a curative treatment for FIP, a diagnostic protocol for FCoV would greatly assist in the management and control of the virus. Clinical findings in FIP are non-specific and not helpful in making a differential diagnosis. Haematological and biochemical abnormalities in FIP cases are also non-specific. The currently available serological tests have low specificity and sensitivity for detection of active infection and cross-react with FCoV strains of low pathogenicity, the feline enteric coronaviruses (FECV). Reverse transcriptase polymerase chain reaction (RT-PCR) has been used to detect FCoV and is rapid and sensitive, but results must be interpreted in the context of clinical findings. At present, a definitive diagnosis of FIP can be established only by histopathological examination of biopsies. This paper describes and compares diagnostic methods for FCoVs and includes a brief account of the virus biology, epidemiology, and pathogenesis.http://dx.doi.org/10.4061/2010/809480 |
| spellingShingle | Saeed Sharif Siti Suri Arshad Mohd Hair-Bejo Abdul Rahman Omar Nazariah Allaudin Zeenathul Amer Alazawy Diagnostic Methods for Feline Coronavirus: A Review Veterinary Medicine International |
| title | Diagnostic Methods for Feline Coronavirus: A Review |
| title_full | Diagnostic Methods for Feline Coronavirus: A Review |
| title_fullStr | Diagnostic Methods for Feline Coronavirus: A Review |
| title_full_unstemmed | Diagnostic Methods for Feline Coronavirus: A Review |
| title_short | Diagnostic Methods for Feline Coronavirus: A Review |
| title_sort | diagnostic methods for feline coronavirus a review |
| url | http://dx.doi.org/10.4061/2010/809480 |
| work_keys_str_mv | AT saeedsharif diagnosticmethodsforfelinecoronavirusareview AT sitisuriarshad diagnosticmethodsforfelinecoronavirusareview AT mohdhairbejo diagnosticmethodsforfelinecoronavirusareview AT abdulrahmanomar diagnosticmethodsforfelinecoronavirusareview AT nazariahallaudinzeenathul diagnosticmethodsforfelinecoronavirusareview AT ameralazawy diagnosticmethodsforfelinecoronavirusareview |