Subacute cutaneous lupus erythematosus triggered by sintilimab: a case report
Immune checkpoint inhibitors (ICIs) have become a standard treatment for various cancers, but their use is often associated with immune-related adverse events (irAEs), including cutaneous irAEs (cirAEs). Here, we report a rare case of subacute cutaneous lupus erythematosus (SCLE) induced by sintilim...
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| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1544312/full |
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| author | Chenxi Zhang Xiaoying Zhang Jiali Liang Yifei Liu Jialong Chen Qi Wang Changxing Li Changxing Li |
| author_facet | Chenxi Zhang Xiaoying Zhang Jiali Liang Yifei Liu Jialong Chen Qi Wang Changxing Li Changxing Li |
| author_sort | Chenxi Zhang |
| collection | DOAJ |
| description | Immune checkpoint inhibitors (ICIs) have become a standard treatment for various cancers, but their use is often associated with immune-related adverse events (irAEs), including cutaneous irAEs (cirAEs). Here, we report a rare case of subacute cutaneous lupus erythematosus (SCLE) induced by sintilimab, a PD-1 inhibitor, in a 30-year-old woman undergoing neoadjuvant chemo-immunotherapy for gastric cancer. The patient presented with erythema, macules, papules, and vesicles, with positive ANA (108U/mL) and strongly positive anti-SSA/Ro. After discontinuation of sintilimab and treatment with corticosteroids, hydroxychloroquine, and intravenous immunoglobulin (IVIG), her symptoms improved. This case represents the first reported instance of drug-induced lupus caused by sintilimab and emphasizes the importance of distinguishing between paraneoplastic lupus and ICI-induced lupus. |
| format | Article |
| id | doaj-art-e5c0c96fe9f248c0bddc7994e65f1f53 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-e5c0c96fe9f248c0bddc7994e65f1f532025-08-20T03:13:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15443121544312Subacute cutaneous lupus erythematosus triggered by sintilimab: a case reportChenxi Zhang0Xiaoying Zhang1Jiali Liang2Yifei Liu3Jialong Chen4Qi Wang5Changxing Li6Changxing Li7Department of Dermatology, Southern Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Dermatology, Southern Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Dermatology, Southern Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Dermatology, Southern Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Dermatology, Southern Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Dermatology, Southern Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Dermatology, Southern Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Dermatology, the Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, ChinaImmune checkpoint inhibitors (ICIs) have become a standard treatment for various cancers, but their use is often associated with immune-related adverse events (irAEs), including cutaneous irAEs (cirAEs). Here, we report a rare case of subacute cutaneous lupus erythematosus (SCLE) induced by sintilimab, a PD-1 inhibitor, in a 30-year-old woman undergoing neoadjuvant chemo-immunotherapy for gastric cancer. The patient presented with erythema, macules, papules, and vesicles, with positive ANA (108U/mL) and strongly positive anti-SSA/Ro. After discontinuation of sintilimab and treatment with corticosteroids, hydroxychloroquine, and intravenous immunoglobulin (IVIG), her symptoms improved. This case represents the first reported instance of drug-induced lupus caused by sintilimab and emphasizes the importance of distinguishing between paraneoplastic lupus and ICI-induced lupus.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1544312/fullsintilimabPD-1 inhibitorimmune-related adverse eventssubacute cutaneous lupus erythematosusimmunotherapy |
| spellingShingle | Chenxi Zhang Xiaoying Zhang Jiali Liang Yifei Liu Jialong Chen Qi Wang Changxing Li Changxing Li Subacute cutaneous lupus erythematosus triggered by sintilimab: a case report Frontiers in Immunology sintilimab PD-1 inhibitor immune-related adverse events subacute cutaneous lupus erythematosus immunotherapy |
| title | Subacute cutaneous lupus erythematosus triggered by sintilimab: a case report |
| title_full | Subacute cutaneous lupus erythematosus triggered by sintilimab: a case report |
| title_fullStr | Subacute cutaneous lupus erythematosus triggered by sintilimab: a case report |
| title_full_unstemmed | Subacute cutaneous lupus erythematosus triggered by sintilimab: a case report |
| title_short | Subacute cutaneous lupus erythematosus triggered by sintilimab: a case report |
| title_sort | subacute cutaneous lupus erythematosus triggered by sintilimab a case report |
| topic | sintilimab PD-1 inhibitor immune-related adverse events subacute cutaneous lupus erythematosus immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1544312/full |
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