The effect of the PKR inhibitor, 2-aminopurine, on the replication of influenza A virus, and segment 8 mRNA splicing
Influenza A virus (IAV) is a negative-sense, single-stranded RNA virus, whose genome consists of eight segments encoding multiple structural and non-structural proteins essential for viral replication and host immune evasion. Among these, segment 8 encodes two primary non-structural proteins NS1, c...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-04-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2025-1098 |
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| author | Lorent Dagny Nowak Rafal Gazecka Monika Zmora Pawel Onyekaa Elzbieta Lenartowicz |
| author_facet | Lorent Dagny Nowak Rafal Gazecka Monika Zmora Pawel Onyekaa Elzbieta Lenartowicz |
| author_sort | Lorent Dagny |
| collection | DOAJ |
| description | Influenza A virus (IAV) is a negative-sense, single-stranded RNA virus, whose genome consists of eight segments encoding multiple structural and non-structural proteins essential for viral replication and host immune evasion. Among these, segment 8 encodes two primary non-structural proteins NS1, crucial for host immune suppression and virulence and NS2, involved in vRNP export – and their expression is regulated by splicing. Further studies are required to elucidate the role of PKR in IAV mRNA splicing regulation. |
| format | Article |
| id | doaj-art-e5bccecf7b7746db9e34a3195b02fc63 |
| institution | OA Journals |
| issn | 2391-5412 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj-art-e5bccecf7b7746db9e34a3195b02fc632025-08-20T01:48:37ZengDe GruyterOpen Life Sciences2391-54122025-04-0120111110.1515/biol-2025-1098The effect of the PKR inhibitor, 2-aminopurine, on the replication of influenza A virus, and segment 8 mRNA splicingLorent Dagny0Nowak Rafal1Gazecka Monika2Zmora Pawel3Onyekaa Elzbieta Lenartowicz4Department of Molecular Virology, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, PolandDepartment of Molecular Virology, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, PolandDepartment of Molecular Virology, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, PolandDepartment of Molecular Virology, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, PolandLaboratory of Molecular Diagnostics, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, PolandInfluenza A virus (IAV) is a negative-sense, single-stranded RNA virus, whose genome consists of eight segments encoding multiple structural and non-structural proteins essential for viral replication and host immune evasion. Among these, segment 8 encodes two primary non-structural proteins NS1, crucial for host immune suppression and virulence and NS2, involved in vRNP export – and their expression is regulated by splicing. Further studies are required to elucidate the role of PKR in IAV mRNA splicing regulation.https://doi.org/10.1515/biol-2025-1098influenza a virusmrna splicingpseudoknot structuredouble-stranded rna-activated protein kinasenon-structural proteins ns1 and ns2 |
| spellingShingle | Lorent Dagny Nowak Rafal Gazecka Monika Zmora Pawel Onyekaa Elzbieta Lenartowicz The effect of the PKR inhibitor, 2-aminopurine, on the replication of influenza A virus, and segment 8 mRNA splicing Open Life Sciences influenza a virus mrna splicing pseudoknot structure double-stranded rna-activated protein kinase non-structural proteins ns1 and ns2 |
| title | The effect of the PKR inhibitor, 2-aminopurine, on the replication of influenza A virus, and segment 8 mRNA splicing |
| title_full | The effect of the PKR inhibitor, 2-aminopurine, on the replication of influenza A virus, and segment 8 mRNA splicing |
| title_fullStr | The effect of the PKR inhibitor, 2-aminopurine, on the replication of influenza A virus, and segment 8 mRNA splicing |
| title_full_unstemmed | The effect of the PKR inhibitor, 2-aminopurine, on the replication of influenza A virus, and segment 8 mRNA splicing |
| title_short | The effect of the PKR inhibitor, 2-aminopurine, on the replication of influenza A virus, and segment 8 mRNA splicing |
| title_sort | effect of the pkr inhibitor 2 aminopurine on the replication of influenza a virus and segment 8 mrna splicing |
| topic | influenza a virus mrna splicing pseudoknot structure double-stranded rna-activated protein kinase non-structural proteins ns1 and ns2 |
| url | https://doi.org/10.1515/biol-2025-1098 |
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