The effect of the PKR inhibitor, 2-aminopurine, on the replication of influenza A virus, and segment 8 mRNA splicing

The effect of the PKR inhibitor, 2-aminopurine, on the replication of influenza A virus, and segment 8 mRNA splicing

Influenza A virus (IAV) is a negative-sense, single-stranded RNA virus, whose genome consists of eight segments encoding multiple structural and non-structural proteins essential for viral replication and host immune evasion. Among these, segment 8 encodes two primary non-structural proteins  NS1, c...

Full description

Saved in:
Bibliographic Details
Main Authors: Lorent Dagny, Nowak Rafal, Gazecka Monika, Zmora Pawel, Onyekaa Elzbieta Lenartowicz
Format: Article
Language:English
Published: De Gruyter 2025-04-01
Series:Open Life Sciences
Subjects:
influenza a virus
mrna splicing
pseudoknot structure
double-stranded rna-activated protein kinase
non-structural proteins ns1 and ns2
Online Access:https://doi.org/10.1515/biol-2025-1098
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Influenza A virus (IAV) is a negative-sense, single-stranded RNA virus, whose genome consists of eight segments encoding multiple structural and non-structural proteins essential for viral replication and host immune evasion. Among these, segment 8 encodes two primary non-structural proteins  NS1, crucial for host immune suppression and virulence and NS2, involved in vRNP export – and their expression is regulated by splicing. Further studies are required to elucidate the role of PKR in IAV mRNA splicing regulation.
ISSN:2391-5412

Similar Items