Apomorphine for prolonged disorders of consciousness: a multimodal open-label studyResearch in context

Apomorphine for prolonged disorders of consciousness: a multimodal open-label studyResearch in context

Summary: Background: Apomorphine is a dopaminergic candidate therapy to improve recovery in patients with prolonged disorders of consciousness (PDoC). Behavioural improvements were previously described in non-controlled case series, but its efficacy and neural mechanisms remain largely unknown. Thi...

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Main Authors: Leandro R.D. Sanz, Nicolas Lejeune, Emilie Szymkowicz, Estelle A.C. Bonin, Rajanikant Panda, Arianna Sala, Aurore Thibaut, Rodrigo Huerta-Gutierrez, Nadia Dardenne, David Dikenstein, Sébastien Van Goethem, Didier Ledoux, Roland Hustinx, Johan Stender, Neal M. Farber, Ross D. Zafonte, Nicholas D. Schiff, Steven Laureys, Olivia Gosseries
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:EClinicalMedicine
Subjects:
Disorders of consciousness
Coma
Severe brain injury
Unresponsive wakefulness syndrome
Vegetative state
Minimally conscious state
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537024005042
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