Regionally Specific Regulation of Sensorimotor Network Connectivity Following Tactile Improvement
Correlations between inherent, task-free low-frequency fluctuations in the blood oxygenation level-dependent (BOLD) signals of the brain provide a potent tool to delineate its functional architecture in terms of intrinsic functional connectivity (iFC). Still, it remains unclear how iFC is modulated...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/5270532 |
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| author | Stefanie Heba Melanie Lenz Tobias Kalisch Oliver Höffken Lauren M. Schweizer Benjamin Glaubitz Nicolaas A. J. Puts Martin Tegenthoff Hubert R. Dinse Tobias Schmidt-Wilcke |
| author_facet | Stefanie Heba Melanie Lenz Tobias Kalisch Oliver Höffken Lauren M. Schweizer Benjamin Glaubitz Nicolaas A. J. Puts Martin Tegenthoff Hubert R. Dinse Tobias Schmidt-Wilcke |
| author_sort | Stefanie Heba |
| collection | DOAJ |
| description | Correlations between inherent, task-free low-frequency fluctuations in the blood oxygenation level-dependent (BOLD) signals of the brain provide a potent tool to delineate its functional architecture in terms of intrinsic functional connectivity (iFC). Still, it remains unclear how iFC is modulated during learning. We employed whole-brain resting-state magnetic resonance imaging prior to and after training-independent repetitive sensory stimulation (rSS), which is known to induce somatosensory cortical reorganization. We investigated which areas in the sensorimotor network are susceptible to neural plasticity (i.e., where changes in functional connectivity occurred) and where iFC might be indicative of enhanced tactile performance. We hypothesized iFC to increase in those brain regions primarily receiving the afferent tactile input. Strengthened intrinsic connectivity within the sensorimotor network after rSS was found not only in the postcentral gyrus contralateral to the stimulated hand, but also in associative brain regions, where iFC correlated positively with tactile performance or learning. We also observed that rSS led to attenuation of the network at higher cortical levels, which possibly promotes facilitation of tactile discrimination. We found that resting-state BOLD fluctuations are linked to behavioral performance and sensory learning, indicating that network fluctuations at rest are predictive of behavioral changes and neuroplasticity. |
| format | Article |
| id | doaj-art-e5b5af4818d940e1a78b6e4535510b11 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e5b5af4818d940e1a78b6e4535510b112025-08-20T03:26:17ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/52705325270532Regionally Specific Regulation of Sensorimotor Network Connectivity Following Tactile ImprovementStefanie Heba0Melanie Lenz1Tobias Kalisch2Oliver Höffken3Lauren M. Schweizer4Benjamin Glaubitz5Nicolaas A. J. Puts6Martin Tegenthoff7Hubert R. Dinse8Tobias Schmidt-Wilcke9Department of Neurology, BG University Hospital Bergmannsheil, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, GermanyDepartment of Neurology, BG University Hospital Bergmannsheil, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, GermanyDepartment of Neurology, BG University Hospital Bergmannsheil, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, GermanyDepartment of Neurology, BG University Hospital Bergmannsheil, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, GermanyDepartment of Neurology, BG University Hospital Bergmannsheil, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, GermanyDepartment of Neurology, BG University Hospital Bergmannsheil, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, GermanyRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, MD 21287-0006, USADepartment of Neurology, BG University Hospital Bergmannsheil, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, GermanyDepartment of Neurology, BG University Hospital Bergmannsheil, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, GermanyDepartment of Neurology, BG University Hospital Bergmannsheil, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, GermanyCorrelations between inherent, task-free low-frequency fluctuations in the blood oxygenation level-dependent (BOLD) signals of the brain provide a potent tool to delineate its functional architecture in terms of intrinsic functional connectivity (iFC). Still, it remains unclear how iFC is modulated during learning. We employed whole-brain resting-state magnetic resonance imaging prior to and after training-independent repetitive sensory stimulation (rSS), which is known to induce somatosensory cortical reorganization. We investigated which areas in the sensorimotor network are susceptible to neural plasticity (i.e., where changes in functional connectivity occurred) and where iFC might be indicative of enhanced tactile performance. We hypothesized iFC to increase in those brain regions primarily receiving the afferent tactile input. Strengthened intrinsic connectivity within the sensorimotor network after rSS was found not only in the postcentral gyrus contralateral to the stimulated hand, but also in associative brain regions, where iFC correlated positively with tactile performance or learning. We also observed that rSS led to attenuation of the network at higher cortical levels, which possibly promotes facilitation of tactile discrimination. We found that resting-state BOLD fluctuations are linked to behavioral performance and sensory learning, indicating that network fluctuations at rest are predictive of behavioral changes and neuroplasticity.http://dx.doi.org/10.1155/2017/5270532 |
| spellingShingle | Stefanie Heba Melanie Lenz Tobias Kalisch Oliver Höffken Lauren M. Schweizer Benjamin Glaubitz Nicolaas A. J. Puts Martin Tegenthoff Hubert R. Dinse Tobias Schmidt-Wilcke Regionally Specific Regulation of Sensorimotor Network Connectivity Following Tactile Improvement Neural Plasticity |
| title | Regionally Specific Regulation of Sensorimotor Network Connectivity Following Tactile Improvement |
| title_full | Regionally Specific Regulation of Sensorimotor Network Connectivity Following Tactile Improvement |
| title_fullStr | Regionally Specific Regulation of Sensorimotor Network Connectivity Following Tactile Improvement |
| title_full_unstemmed | Regionally Specific Regulation of Sensorimotor Network Connectivity Following Tactile Improvement |
| title_short | Regionally Specific Regulation of Sensorimotor Network Connectivity Following Tactile Improvement |
| title_sort | regionally specific regulation of sensorimotor network connectivity following tactile improvement |
| url | http://dx.doi.org/10.1155/2017/5270532 |
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