Hypolipidemic effect of coffee silver skin in rats fed a high-fat diet
The present study was conducted to evaluate the hypolipidemic effects of coffee silver skin (CSS) supplementation in rats fed a highfat diet (HFD). A total of 40 albino rats were used in the present study. The groups were as follows: Rats fed a normal diet, N group; high fat diet, HFD group; high fa...
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Tsinghua University Press
2018-12-01
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| Series: | Food Science and Human Wellness |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453017301908 |
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| author | Ayman Mohammed El-Anany Rehab Farouk M. Ali |
| author_facet | Ayman Mohammed El-Anany Rehab Farouk M. Ali |
| author_sort | Ayman Mohammed El-Anany |
| collection | DOAJ |
| description | The present study was conducted to evaluate the hypolipidemic effects of coffee silver skin (CSS) supplementation in rats fed a highfat diet (HFD). A total of 40 albino rats were used in the present study. The groups were as follows: Rats fed a normal diet, N group; high fat diet, HFD group; high fat diet +10% CSS, HFD 10; HFD + 15% CSS, HFD 15; HFD + 20% CSS, HFD 20; the diets were followed for 8 weeks. Blood samples were collected at the end of the experiment. At the time of sacrifice, the weights of heart, liver, kidneys, epididymal fat and retroperitoneal fat of the experimental rats with respect to body weight were recorded. The lipid parameter of the serum was recorded and liver and kidney function tests were conducted. Finally, a histopathological assay was performed on the liver and kidney tissues of the rats fed the tested diets. The weight gain of the rats fed a HFD supplemented with 10, 15 and 20% CSS was ∼1.05, 1.08 and 1.12 times lower than that of those rats fed HFD, respectively. The incorporation of CSS at a level of 20% reduced the increase in liver, kidney, epididymal fat and retroperitoneal fat weight by 17.84, 19.38, 47.23 and 18.00%, respectively, compared with HFD alone. HFD administration induced considerable increases in alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activities compared with the control group. The results also indicated that the HFD-fed rats exhibited increased levels of urea, uric acid and creatinine, by ∼26.38, 8.40 and 6.75%, respectively, compared with the control rats. With the exception of high-density lipoprotein cholesterol, all lipid fractions increased significantly in rats fed a HFD. The administration of a HFD induced marked pathological changes in the liver and kidneys of the rats. However, the incorporation of various levels of CSS in to a HFD reduced these changes. The results of the present study illustrate that the incorporation of CSS into HFDs reduces the hyperlipidemia effect of these diets. Keywords: Hypolipidemic, Coffee, Fiber, Biochemical, Serum lipid |
| format | Article |
| id | doaj-art-e5b4a2f56754471f8e97450beb2cb7b0 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Tsinghua University Press |
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| series | Food Science and Human Wellness |
| spelling | doaj-art-e5b4a2f56754471f8e97450beb2cb7b02025-02-03T05:17:40ZengTsinghua University PressFood Science and Human Wellness2213-45302018-12-0174252259Hypolipidemic effect of coffee silver skin in rats fed a high-fat dietAyman Mohammed El-Anany0Rehab Farouk M. Ali1Department of Special Food and Nutrition Researches, Food Technology Research Institute, Agricultural Research Center, Giza, EgyptBiochemistry Department, Faculty of Agriculture, Cairo University, Giza, Egypt; Department of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Al-Qassum University, Qassim, Saudi Arab; Corresponding author at: Department of Biochemistry, Faculty of Agriculture, Cairo University, El-Gamma Street, Giza 12613, Egypt.The present study was conducted to evaluate the hypolipidemic effects of coffee silver skin (CSS) supplementation in rats fed a highfat diet (HFD). A total of 40 albino rats were used in the present study. The groups were as follows: Rats fed a normal diet, N group; high fat diet, HFD group; high fat diet +10% CSS, HFD 10; HFD + 15% CSS, HFD 15; HFD + 20% CSS, HFD 20; the diets were followed for 8 weeks. Blood samples were collected at the end of the experiment. At the time of sacrifice, the weights of heart, liver, kidneys, epididymal fat and retroperitoneal fat of the experimental rats with respect to body weight were recorded. The lipid parameter of the serum was recorded and liver and kidney function tests were conducted. Finally, a histopathological assay was performed on the liver and kidney tissues of the rats fed the tested diets. The weight gain of the rats fed a HFD supplemented with 10, 15 and 20% CSS was ∼1.05, 1.08 and 1.12 times lower than that of those rats fed HFD, respectively. The incorporation of CSS at a level of 20% reduced the increase in liver, kidney, epididymal fat and retroperitoneal fat weight by 17.84, 19.38, 47.23 and 18.00%, respectively, compared with HFD alone. HFD administration induced considerable increases in alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activities compared with the control group. The results also indicated that the HFD-fed rats exhibited increased levels of urea, uric acid and creatinine, by ∼26.38, 8.40 and 6.75%, respectively, compared with the control rats. With the exception of high-density lipoprotein cholesterol, all lipid fractions increased significantly in rats fed a HFD. The administration of a HFD induced marked pathological changes in the liver and kidneys of the rats. However, the incorporation of various levels of CSS in to a HFD reduced these changes. The results of the present study illustrate that the incorporation of CSS into HFDs reduces the hyperlipidemia effect of these diets. Keywords: Hypolipidemic, Coffee, Fiber, Biochemical, Serum lipidhttp://www.sciencedirect.com/science/article/pii/S2213453017301908 |
| spellingShingle | Ayman Mohammed El-Anany Rehab Farouk M. Ali Hypolipidemic effect of coffee silver skin in rats fed a high-fat diet Food Science and Human Wellness |
| title | Hypolipidemic effect of coffee silver skin in rats fed a high-fat diet |
| title_full | Hypolipidemic effect of coffee silver skin in rats fed a high-fat diet |
| title_fullStr | Hypolipidemic effect of coffee silver skin in rats fed a high-fat diet |
| title_full_unstemmed | Hypolipidemic effect of coffee silver skin in rats fed a high-fat diet |
| title_short | Hypolipidemic effect of coffee silver skin in rats fed a high-fat diet |
| title_sort | hypolipidemic effect of coffee silver skin in rats fed a high fat diet |
| url | http://www.sciencedirect.com/science/article/pii/S2213453017301908 |
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