CMR assessment of epicardial edipose tissue in relation to myocardial inflammation and fibrosis in patients with new-onset atrial arrhythmias after STEMI
Abstract Background Previous studies have shown that epicardial edipose tissue(EAT) appears to be associated with myocardial inflammation and fibrosis, but this is not clear in patients with new-onset atrial arrhythmias after STEMI. The present study focused on using CMR to assess the association of...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-025-04486-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586095163867136 |
|---|---|
| author | Yanfei Ren Xinjia Du Maochen Li Lei Chen Jiahua Liu Yixuan Wu Yuan Lu |
| author_facet | Yanfei Ren Xinjia Du Maochen Li Lei Chen Jiahua Liu Yixuan Wu Yuan Lu |
| author_sort | Yanfei Ren |
| collection | DOAJ |
| description | Abstract Background Previous studies have shown that epicardial edipose tissue(EAT) appears to be associated with myocardial inflammation and fibrosis, but this is not clear in patients with new-onset atrial arrhythmias after STEMI. The present study focused on using CMR to assess the association of epicardial fat with myocardial inflammation and fibrosis and its predictive value in patients with new-onset atrial arrhythmias after STEMI. Methods This was a single-centre, retrospective study. We consecutively selected patients who completed CMR during their hospitalisation for PCI after STEMI from May 2019-January 2023, and then underwent regular follow-up, grouped by the presence or absence of new atrial arrhythmias, and enrolled patients were divided into atrial arrhythmia and non-atrial arrhythmia groups. Results In the atrial arrhythmia group, age, heart rate, Peak hs-TnT, PeakNT-proBNP, EATV, LAES, LAED, T1 native, T1*, ECV, and T2 were higher than those in the non-atrial arrhythmia group, and LVEF was lower than those in the non-atrial arrhythmia group. EATV showed a positive and significant correlation with T1native, T1*, ECV, and T2. (T1 native: r = 0.476,p < 0.001; ECV: r = 0.529,p < 0.001; T1*: r = 0.467,p < 0.001; T2: r = 0.538,p < 0.001). Multifactorial logistic regression analysis showed age, LVEF, EATV, T1*,ECV, T2 as independent risk factors for atrial arrhythmia. (p < 0.05) ROC analysis showed that the AUC for age was 0.568; AUC for LVEF was 0.656; AUC for EATV was 0.768; AUC for ECV was 0.705; AUC for T1* was 0.612; and AUC for T2 was 0.772. Conclusion In patients with STEMI, EAT is associated with myocardial inflammation, fibrosis. Age, LVEF, EATV, T1*,ECV, T2 are independent risk factors for new onset atrial arrhythmias and have good predictive value. |
| format | Article |
| id | doaj-art-e5b41598d7da414ea742e5ff0fda0ee1 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-e5b41598d7da414ea742e5ff0fda0ee12025-01-26T12:14:20ZengBMCBMC Cardiovascular Disorders1471-22612025-01-0125111010.1186/s12872-025-04486-1CMR assessment of epicardial edipose tissue in relation to myocardial inflammation and fibrosis in patients with new-onset atrial arrhythmias after STEMIYanfei Ren0Xinjia Du1Maochen Li2Lei Chen3Jiahua Liu4Yixuan Wu5Yuan Lu6Department of Cardiology, The Affiliated Hospital of Xuzhou Medical UniversityDepartment of Cardiology, The Affiliated Hospital of Xuzhou Medical UniversityDepartment of Cardiology, The Affiliated Hospital of Xuzhou Medical UniversityDepartment of Cardiology, Tongji University School of Medicine, Shanghai Tenth People’s HospitalDepartment of Cardiology, The Affiliated Hospital of Xuzhou Medical UniversityDepartment of Cardiology, The Affiliated Hospital of Xuzhou Medical UniversityDepartment of Cardiology, The Affiliated Hospital of Xuzhou Medical UniversityAbstract Background Previous studies have shown that epicardial edipose tissue(EAT) appears to be associated with myocardial inflammation and fibrosis, but this is not clear in patients with new-onset atrial arrhythmias after STEMI. The present study focused on using CMR to assess the association of epicardial fat with myocardial inflammation and fibrosis and its predictive value in patients with new-onset atrial arrhythmias after STEMI. Methods This was a single-centre, retrospective study. We consecutively selected patients who completed CMR during their hospitalisation for PCI after STEMI from May 2019-January 2023, and then underwent regular follow-up, grouped by the presence or absence of new atrial arrhythmias, and enrolled patients were divided into atrial arrhythmia and non-atrial arrhythmia groups. Results In the atrial arrhythmia group, age, heart rate, Peak hs-TnT, PeakNT-proBNP, EATV, LAES, LAED, T1 native, T1*, ECV, and T2 were higher than those in the non-atrial arrhythmia group, and LVEF was lower than those in the non-atrial arrhythmia group. EATV showed a positive and significant correlation with T1native, T1*, ECV, and T2. (T1 native: r = 0.476,p < 0.001; ECV: r = 0.529,p < 0.001; T1*: r = 0.467,p < 0.001; T2: r = 0.538,p < 0.001). Multifactorial logistic regression analysis showed age, LVEF, EATV, T1*,ECV, T2 as independent risk factors for atrial arrhythmia. (p < 0.05) ROC analysis showed that the AUC for age was 0.568; AUC for LVEF was 0.656; AUC for EATV was 0.768; AUC for ECV was 0.705; AUC for T1* was 0.612; and AUC for T2 was 0.772. Conclusion In patients with STEMI, EAT is associated with myocardial inflammation, fibrosis. Age, LVEF, EATV, T1*,ECV, T2 are independent risk factors for new onset atrial arrhythmias and have good predictive value.https://doi.org/10.1186/s12872-025-04486-1Epicardial adipose tissueT1mappingECVT2mappingCMRAtrial arrhythmia |
| spellingShingle | Yanfei Ren Xinjia Du Maochen Li Lei Chen Jiahua Liu Yixuan Wu Yuan Lu CMR assessment of epicardial edipose tissue in relation to myocardial inflammation and fibrosis in patients with new-onset atrial arrhythmias after STEMI BMC Cardiovascular Disorders Epicardial adipose tissue T1mapping ECV T2mapping CMR Atrial arrhythmia |
| title | CMR assessment of epicardial edipose tissue in relation to myocardial inflammation and fibrosis in patients with new-onset atrial arrhythmias after STEMI |
| title_full | CMR assessment of epicardial edipose tissue in relation to myocardial inflammation and fibrosis in patients with new-onset atrial arrhythmias after STEMI |
| title_fullStr | CMR assessment of epicardial edipose tissue in relation to myocardial inflammation and fibrosis in patients with new-onset atrial arrhythmias after STEMI |
| title_full_unstemmed | CMR assessment of epicardial edipose tissue in relation to myocardial inflammation and fibrosis in patients with new-onset atrial arrhythmias after STEMI |
| title_short | CMR assessment of epicardial edipose tissue in relation to myocardial inflammation and fibrosis in patients with new-onset atrial arrhythmias after STEMI |
| title_sort | cmr assessment of epicardial edipose tissue in relation to myocardial inflammation and fibrosis in patients with new onset atrial arrhythmias after stemi |
| topic | Epicardial adipose tissue T1mapping ECV T2mapping CMR Atrial arrhythmia |
| url | https://doi.org/10.1186/s12872-025-04486-1 |
| work_keys_str_mv | AT yanfeiren cmrassessmentofepicardialediposetissueinrelationtomyocardialinflammationandfibrosisinpatientswithnewonsetatrialarrhythmiasafterstemi AT xinjiadu cmrassessmentofepicardialediposetissueinrelationtomyocardialinflammationandfibrosisinpatientswithnewonsetatrialarrhythmiasafterstemi AT maochenli cmrassessmentofepicardialediposetissueinrelationtomyocardialinflammationandfibrosisinpatientswithnewonsetatrialarrhythmiasafterstemi AT leichen cmrassessmentofepicardialediposetissueinrelationtomyocardialinflammationandfibrosisinpatientswithnewonsetatrialarrhythmiasafterstemi AT jiahualiu cmrassessmentofepicardialediposetissueinrelationtomyocardialinflammationandfibrosisinpatientswithnewonsetatrialarrhythmiasafterstemi AT yixuanwu cmrassessmentofepicardialediposetissueinrelationtomyocardialinflammationandfibrosisinpatientswithnewonsetatrialarrhythmiasafterstemi AT yuanlu cmrassessmentofepicardialediposetissueinrelationtomyocardialinflammationandfibrosisinpatientswithnewonsetatrialarrhythmiasafterstemi |