Vaccines: from empirical development to rational design.
Infectious diseases are responsible for an overwhelming number of deaths worldwide and their clinical management is often hampered by the emergence of multi-drug-resistant strains. Therefore, prevention through vaccination currently represents the best course of action to combat them. However, immun...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003001&type=printable |
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| _version_ | 1849720491139399680 |
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| author | Christine Rueckert Carlos A Guzmán |
| author_facet | Christine Rueckert Carlos A Guzmán |
| author_sort | Christine Rueckert |
| collection | DOAJ |
| description | Infectious diseases are responsible for an overwhelming number of deaths worldwide and their clinical management is often hampered by the emergence of multi-drug-resistant strains. Therefore, prevention through vaccination currently represents the best course of action to combat them. However, immune escape and evasion by pathogens often render vaccine development difficult. Furthermore, most currently available vaccines were empirically designed. In this review, we discuss why rational design of vaccines is not only desirable but also necessary. We introduce recent developments towards specifically tailored antigens, adjuvants, and delivery systems, and discuss the methodological gaps and lack of knowledge still hampering true rational vaccine design. Finally, we address the potential and limitations of different strategies and technologies for advancing vaccine development. |
| format | Article |
| id | doaj-art-e5b2bda943f7412fb2e7a760ee91423f |
| institution | DOAJ |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-e5b2bda943f7412fb2e7a760ee91423f2025-08-20T03:11:54ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742012-01-01811e100300110.1371/journal.ppat.1003001Vaccines: from empirical development to rational design.Christine RueckertCarlos A GuzmánInfectious diseases are responsible for an overwhelming number of deaths worldwide and their clinical management is often hampered by the emergence of multi-drug-resistant strains. Therefore, prevention through vaccination currently represents the best course of action to combat them. However, immune escape and evasion by pathogens often render vaccine development difficult. Furthermore, most currently available vaccines were empirically designed. In this review, we discuss why rational design of vaccines is not only desirable but also necessary. We introduce recent developments towards specifically tailored antigens, adjuvants, and delivery systems, and discuss the methodological gaps and lack of knowledge still hampering true rational vaccine design. Finally, we address the potential and limitations of different strategies and technologies for advancing vaccine development.https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003001&type=printable |
| spellingShingle | Christine Rueckert Carlos A Guzmán Vaccines: from empirical development to rational design. PLoS Pathogens |
| title | Vaccines: from empirical development to rational design. |
| title_full | Vaccines: from empirical development to rational design. |
| title_fullStr | Vaccines: from empirical development to rational design. |
| title_full_unstemmed | Vaccines: from empirical development to rational design. |
| title_short | Vaccines: from empirical development to rational design. |
| title_sort | vaccines from empirical development to rational design |
| url | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003001&type=printable |
| work_keys_str_mv | AT christinerueckert vaccinesfromempiricaldevelopmenttorationaldesign AT carlosaguzman vaccinesfromempiricaldevelopmenttorationaldesign |