Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity
The aim of this study was to synthesize a series of nickel(II)phthalocyanines (NiPcs) bearing four 4(3H)-quinazolinone ring system units, (qz)4NiPcs 4a–d. The electronic factors in the 4(3H)-quinazolinone moiety that attached to the NiPc skeleton had a magnificent effect on the antibacterial activit...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2019/5964687 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850166794950541312 |
|---|---|
| author | Asma M. Elsharif Tamer E. Youssef Suhailah S. Al-Jameel Hanan H. Mohamed Mohammad Azam Ansari Suriya Rehman Sultan Akhtar |
| author_facet | Asma M. Elsharif Tamer E. Youssef Suhailah S. Al-Jameel Hanan H. Mohamed Mohammad Azam Ansari Suriya Rehman Sultan Akhtar |
| author_sort | Asma M. Elsharif |
| collection | DOAJ |
| description | The aim of this study was to synthesize a series of nickel(II)phthalocyanines (NiPcs) bearing four 4(3H)-quinazolinone ring system units, (qz)4NiPcs 4a–d. The electronic factors in the 4(3H)-quinazolinone moiety that attached to the NiPc skeleton had a magnificent effect on the antibacterial activity of the newly synthesized (qz)4NiPcs 4a–d against Escherichia coli. The minimum MICs and MBCs value were recorded for compounds 4a, 4b, 4c, and 4d, respectively. The results indicated that the studied (qz)4NiPcs 4a–d units possessed a broad spectrum of activity against Escherichia coli. Their antibacterial activities were found in the order of 4d > 4c > 4b > 4a against Escherichia coli, and the strongest antibacterial activity was achieved with compound 4d. |
| format | Article |
| id | doaj-art-e5af28e8835446b28060fb34d0087146 |
| institution | OA Journals |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-e5af28e8835446b28060fb34d00871462025-08-20T02:21:20ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422019-01-01201910.1155/2019/59646875964687Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial ActivityAsma M. Elsharif0Tamer E. Youssef1Suhailah S. Al-Jameel2Hanan H. Mohamed3Mohammad Azam Ansari4Suriya Rehman5Sultan Akhtar6Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Epidemic Disease Research, Institute of Research and Medical Consultation (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaDepartment of Epidemic Disease Research, Institute of Research and Medical Consultation (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaDepartment of Physics Research, Institute of Research and Medical Consultation (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaThe aim of this study was to synthesize a series of nickel(II)phthalocyanines (NiPcs) bearing four 4(3H)-quinazolinone ring system units, (qz)4NiPcs 4a–d. The electronic factors in the 4(3H)-quinazolinone moiety that attached to the NiPc skeleton had a magnificent effect on the antibacterial activity of the newly synthesized (qz)4NiPcs 4a–d against Escherichia coli. The minimum MICs and MBCs value were recorded for compounds 4a, 4b, 4c, and 4d, respectively. The results indicated that the studied (qz)4NiPcs 4a–d units possessed a broad spectrum of activity against Escherichia coli. Their antibacterial activities were found in the order of 4d > 4c > 4b > 4a against Escherichia coli, and the strongest antibacterial activity was achieved with compound 4d.http://dx.doi.org/10.1155/2019/5964687 |
| spellingShingle | Asma M. Elsharif Tamer E. Youssef Suhailah S. Al-Jameel Hanan H. Mohamed Mohammad Azam Ansari Suriya Rehman Sultan Akhtar Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity Advances in Pharmacological Sciences |
| title | Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity |
| title_full | Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity |
| title_fullStr | Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity |
| title_full_unstemmed | Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity |
| title_short | Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity |
| title_sort | synthesis of an activatable tetra substituted nickel phthalocyanines 4 3h quinazolinone conjugate and its antibacterial activity |
| url | http://dx.doi.org/10.1155/2019/5964687 |
| work_keys_str_mv | AT asmamelsharif synthesisofanactivatabletetrasubstitutednickelphthalocyanines43hquinazolinoneconjugateanditsantibacterialactivity AT tamereyoussef synthesisofanactivatabletetrasubstitutednickelphthalocyanines43hquinazolinoneconjugateanditsantibacterialactivity AT suhailahsaljameel synthesisofanactivatabletetrasubstitutednickelphthalocyanines43hquinazolinoneconjugateanditsantibacterialactivity AT hananhmohamed synthesisofanactivatabletetrasubstitutednickelphthalocyanines43hquinazolinoneconjugateanditsantibacterialactivity AT mohammadazamansari synthesisofanactivatabletetrasubstitutednickelphthalocyanines43hquinazolinoneconjugateanditsantibacterialactivity AT suriyarehman synthesisofanactivatabletetrasubstitutednickelphthalocyanines43hquinazolinoneconjugateanditsantibacterialactivity AT sultanakhtar synthesisofanactivatabletetrasubstitutednickelphthalocyanines43hquinazolinoneconjugateanditsantibacterialactivity |