Supercell-enhanced multimodal plasmonic sensor for high-fidelity antigen detection via refractive index modulation
Abstract In this study, we investigate a multispectral plasmonic refractive index sensor based on a ring resonator supercell array for the detection of carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), and hemoglobin (Hb). The sensor exhibits three resonance modes within the 1000–3000...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-08081-4 |
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| author | MohammadAli Shokrzadeh Moghtader Hamid Heidarzadeh Ali Khodaie |
| author_facet | MohammadAli Shokrzadeh Moghtader Hamid Heidarzadeh Ali Khodaie |
| author_sort | MohammadAli Shokrzadeh Moghtader |
| collection | DOAJ |
| description | Abstract In this study, we investigate a multispectral plasmonic refractive index sensor based on a ring resonator supercell array for the detection of carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), and hemoglobin (Hb). The sensor exhibits three resonance modes within the 1000–3000 nm wavelength range, analyzed using the finite-difference time-domain (FDTD) method. Through meticulous optimization of the sensor’s geometrical structure, we achieve a high figure of merit (FOM) and sensitivity. Notably, the second resonance mode attains the highest sensitivity of 913.51 nm/RIU. Furthermore, the third resonance mode achieves an FOM exceeding 70 RIU−1, underscoring its potential for specialized biomedical applications. Extensive research has established a strong correlation between elevated antigen concentrations, including CEA, PSA, and hemoglobin, and the presence of cancer and other critical diseases. With advancements in optical biosensing technology, this sensor offers a promising pathway toward cost-effective, portable, and highly sensitive diagnostic tools, contributing to public health and improved quality of life. |
| format | Article |
| id | doaj-art-e5ae484080fa466782eb47d15301cdec |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e5ae484080fa466782eb47d15301cdec2025-08-20T03:03:28ZengNature PortfolioScientific Reports2045-23222025-07-0115111210.1038/s41598-025-08081-4Supercell-enhanced multimodal plasmonic sensor for high-fidelity antigen detection via refractive index modulationMohammadAli Shokrzadeh Moghtader0Hamid Heidarzadeh1Ali Khodaie2Department of Electrical and Computer Engineering, University of Mohaghegh ArdabiliDepartment of Electrical and Computer Engineering, University of Mohaghegh ArdabiliDepartment of Electrical and Computer Engineering, University of Mohaghegh ArdabiliAbstract In this study, we investigate a multispectral plasmonic refractive index sensor based on a ring resonator supercell array for the detection of carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), and hemoglobin (Hb). The sensor exhibits three resonance modes within the 1000–3000 nm wavelength range, analyzed using the finite-difference time-domain (FDTD) method. Through meticulous optimization of the sensor’s geometrical structure, we achieve a high figure of merit (FOM) and sensitivity. Notably, the second resonance mode attains the highest sensitivity of 913.51 nm/RIU. Furthermore, the third resonance mode achieves an FOM exceeding 70 RIU−1, underscoring its potential for specialized biomedical applications. Extensive research has established a strong correlation between elevated antigen concentrations, including CEA, PSA, and hemoglobin, and the presence of cancer and other critical diseases. With advancements in optical biosensing technology, this sensor offers a promising pathway toward cost-effective, portable, and highly sensitive diagnostic tools, contributing to public health and improved quality of life.https://doi.org/10.1038/s41598-025-08081-4Optical sensorHigh sensitivityHigher FOMMultimode refractive index (MMRI)Ring resonator supercellPlasmonic |
| spellingShingle | MohammadAli Shokrzadeh Moghtader Hamid Heidarzadeh Ali Khodaie Supercell-enhanced multimodal plasmonic sensor for high-fidelity antigen detection via refractive index modulation Scientific Reports Optical sensor High sensitivity Higher FOM Multimode refractive index (MMRI) Ring resonator supercell Plasmonic |
| title | Supercell-enhanced multimodal plasmonic sensor for high-fidelity antigen detection via refractive index modulation |
| title_full | Supercell-enhanced multimodal plasmonic sensor for high-fidelity antigen detection via refractive index modulation |
| title_fullStr | Supercell-enhanced multimodal plasmonic sensor for high-fidelity antigen detection via refractive index modulation |
| title_full_unstemmed | Supercell-enhanced multimodal plasmonic sensor for high-fidelity antigen detection via refractive index modulation |
| title_short | Supercell-enhanced multimodal plasmonic sensor for high-fidelity antigen detection via refractive index modulation |
| title_sort | supercell enhanced multimodal plasmonic sensor for high fidelity antigen detection via refractive index modulation |
| topic | Optical sensor High sensitivity Higher FOM Multimode refractive index (MMRI) Ring resonator supercell Plasmonic |
| url | https://doi.org/10.1038/s41598-025-08081-4 |
| work_keys_str_mv | AT mohammadalishokrzadehmoghtader supercellenhancedmultimodalplasmonicsensorforhighfidelityantigendetectionviarefractiveindexmodulation AT hamidheidarzadeh supercellenhancedmultimodalplasmonicsensorforhighfidelityantigendetectionviarefractiveindexmodulation AT alikhodaie supercellenhancedmultimodalplasmonicsensorforhighfidelityantigendetectionviarefractiveindexmodulation |