Pharmacokinetics, bioavailability, and tissue distribution of MRTX1133 in rats using UHPLC-MS/MS

Pharmacokinetics, bioavailability, and tissue distribution of MRTX1133 in rats using UHPLC-MS/MS

IntroductionMRTX1133 is a selective and reversible small molecule inhibitor of KRAS (G12D), which significantly delays the progression of solid tumors. However, no study on the absorption, distribution, and excretion of MRTX1133.MethodsA fast ultra-high performance liquid chromatography-tandem quadr...

Full description

Saved in:
Bibliographic Details
Main Authors: Wei Lu, Rong Zeng, Meng Pan, Yuan Zhou, Huijuan Tang, Wanying Shen, Yijun Tang, Pan Lei
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
MRTX1133
UHPLC-MS/MS
pharmacokinetics
distribution
excretion
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1509319/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items