HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals
Background: Peanut is a major cause of food allergy. HLA genes have been consistently associated with peanut allergy in association studies. To date, however, there have been very few genetic studies of peanut allergy in non-Hispanic Black (Black) individuals, a group disproportionately affected by...
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Elsevier
2025-08-01
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| Series: | Journal of Allergy and Clinical Immunology: Global |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829325000864 |
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| author | Baojun Wu, PhD Mao Yang, MS Donglei Hu, PhD Ray Zhang Bin Liu, PhD, MPH Samantha Hochstadt, MS David E. Lanfear, MD, MS Jonathan Witonsky, MD, MAS Rajesh Kumar, MD, MS Jill A. Hollenbach, PhD, MPH Esteban G. Burchard, MD, MPH Elad Ziv, MD L. Keoki Williams, MD, MPH, MBA |
| author_facet | Baojun Wu, PhD Mao Yang, MS Donglei Hu, PhD Ray Zhang Bin Liu, PhD, MPH Samantha Hochstadt, MS David E. Lanfear, MD, MS Jonathan Witonsky, MD, MAS Rajesh Kumar, MD, MS Jill A. Hollenbach, PhD, MPH Esteban G. Burchard, MD, MPH Elad Ziv, MD L. Keoki Williams, MD, MPH, MBA |
| author_sort | Baojun Wu, PhD |
| collection | DOAJ |
| description | Background: Peanut is a major cause of food allergy. HLA genes have been consistently associated with peanut allergy in association studies. To date, however, there have been very few genetic studies of peanut allergy in non-Hispanic Black (Black) individuals, a group disproportionately affected by food allergy. Objective: Our aim was to study the relationship between HLA alleles and peanut allergy among Black individuals. Methods: The analysis consisted of Black participants from the Study of Asthma-Related Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), a large cohort of individuals from metropolitan Detroit. At the time of enrollment, participants provided detailed food allergy histories, including symptoms. Four-digit resolution HLA allele calls were made using whole genome sequence data. Results: The cases consisted of 119 individuals with reported peanut allergy and 59 individuals with peanut-related anaphylaxis; the comparison group consisted of 2640 individuals without reported food allergy. HLA-DRB1∗13:02 was the most significant allele associated with peanut allergy (adjusted odds ratio = 1.94 [95% CI = 1.28-2.93]), and HLA-DQA1∗01:02 was the top association with peanut-related anaphylaxis (aOR = 1.67 [95% CI = 1.14-2.44]). Amino acid polymorphisms at position 71 in the binding groove of HLA-DRB1 were associated with peanut allergy and estimated to affect peanut allergen binding affinity. Conclusions: In a cohort of Black individuals, this study independently identified the same associations of peanut allergy and HLA that were previously observed in non-Hispanic White individuals. Our findings suggest that specific HLA binding groove amino acid polymorphisms may confer similar peanut allergy risk across population groups and HLA alleles. |
| format | Article |
| id | doaj-art-e5a3a2e5ed2140c498bfc73816d03862 |
| institution | Kabale University |
| issn | 2772-8293 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
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| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj-art-e5a3a2e5ed2140c498bfc73816d038622025-08-20T03:42:53ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932025-08-014310048510.1016/j.jacig.2025.100485HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individualsBaojun Wu, PhD0Mao Yang, MS1Donglei Hu, PhD2Ray Zhang3Bin Liu, PhD, MPH4Samantha Hochstadt, MS5David E. Lanfear, MD, MS6Jonathan Witonsky, MD, MAS7Rajesh Kumar, MD, MS8Jill A. Hollenbach, PhD, MPH9Esteban G. Burchard, MD, MPH10Elad Ziv, MD11L. Keoki Williams, MD, MPH, MBA12Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health, Detroit, Mich; Corresponding author: Baojun Wu, PhD, Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, 1 Ford Place, 3A, Detroit, MI 48202.Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health, Detroit, MichDepartment of Medicine, University of California San Francisco, San Francisco, CalifCenter for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health, Detroit, MichCenter for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health, Detroit, MichCenter for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health, Detroit, MichCenter for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health, Detroit, MichDepartment of Pediatrics, University of California San Francisco, San Francisco, CalifDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Ill; Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IllDepartment of Neurology, University of California San Francisco, San Francisco, Calif; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CalifDepartment of Medicine, University of California San Francisco, San Francisco, CalifDepartment of Medicine, University of California San Francisco, San Francisco, CalifCenter for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health, Detroit, Mich; L. Keoki Williams, MD, MPH, MBA, Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, 1 Ford Place, 3A, Detroit, MI 48202.Background: Peanut is a major cause of food allergy. HLA genes have been consistently associated with peanut allergy in association studies. To date, however, there have been very few genetic studies of peanut allergy in non-Hispanic Black (Black) individuals, a group disproportionately affected by food allergy. Objective: Our aim was to study the relationship between HLA alleles and peanut allergy among Black individuals. Methods: The analysis consisted of Black participants from the Study of Asthma-Related Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), a large cohort of individuals from metropolitan Detroit. At the time of enrollment, participants provided detailed food allergy histories, including symptoms. Four-digit resolution HLA allele calls were made using whole genome sequence data. Results: The cases consisted of 119 individuals with reported peanut allergy and 59 individuals with peanut-related anaphylaxis; the comparison group consisted of 2640 individuals without reported food allergy. HLA-DRB1∗13:02 was the most significant allele associated with peanut allergy (adjusted odds ratio = 1.94 [95% CI = 1.28-2.93]), and HLA-DQA1∗01:02 was the top association with peanut-related anaphylaxis (aOR = 1.67 [95% CI = 1.14-2.44]). Amino acid polymorphisms at position 71 in the binding groove of HLA-DRB1 were associated with peanut allergy and estimated to affect peanut allergen binding affinity. Conclusions: In a cohort of Black individuals, this study independently identified the same associations of peanut allergy and HLA that were previously observed in non-Hispanic White individuals. Our findings suggest that specific HLA binding groove amino acid polymorphisms may confer similar peanut allergy risk across population groups and HLA alleles.http://www.sciencedirect.com/science/article/pii/S2772829325000864Peanut hypersensitivityfood hypersensitivityanaphylaxisgenetic association studyHLA antigensMHC |
| spellingShingle | Baojun Wu, PhD Mao Yang, MS Donglei Hu, PhD Ray Zhang Bin Liu, PhD, MPH Samantha Hochstadt, MS David E. Lanfear, MD, MS Jonathan Witonsky, MD, MAS Rajesh Kumar, MD, MS Jill A. Hollenbach, PhD, MPH Esteban G. Burchard, MD, MPH Elad Ziv, MD L. Keoki Williams, MD, MPH, MBA HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals Journal of Allergy and Clinical Immunology: Global Peanut hypersensitivity food hypersensitivity anaphylaxis genetic association study HLA antigens MHC |
| title | HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals |
| title_full | HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals |
| title_fullStr | HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals |
| title_full_unstemmed | HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals |
| title_short | HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals |
| title_sort | hla variation associated with peanut allergy and anaphylaxis among non hispanic black individuals |
| topic | Peanut hypersensitivity food hypersensitivity anaphylaxis genetic association study HLA antigens MHC |
| url | http://www.sciencedirect.com/science/article/pii/S2772829325000864 |
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