CHAC1 in urological tumors: contextual dualism and therapeutic implications

CHAC1 in urological tumors: contextual dualism and therapeutic implications

CHAC1, a glutathione-degrading enzyme, governs context-dependent pathophysiological processes in urological malignancies through modulation of endoplasmic reticulum stress and ferroptotic pathways. In clear cell renal cell carcinoma (ccRCC), CHAC1 exhibits stage-specific functional duality: downregu...

Full description

Saved in:

Bibliographic Details
Main Authors:	Deyu Wang, Yongquan Wan, Yunxiang Li, Yuan Ren, Jiakai Ma, Si Ge, Ziqiang Zeng, Zuoping Wang, Lei Zhen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Oncology
Subjects:	CHAC1 glutathione metabolism ferroptosis endoplasmic reticulum stress prognostic biomarker drug resistance
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1610915/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

CHAC1 Mediates Endoplasmic Reticulum Stress‐Dependent Ferroptosis in Calcium Oxalate Kidney Stone Formation
by: Caitao Dong, et al.
Published: (2025-03-01)

Perfluorooctane sulfonate mediates GSH degradation leading to oral keratinocytes ferroptosis and mucositis through activation of the ER stress-ATF4-CHAC1 axis
by: Ningning Yang, et al.
Published: (2025-03-01)

CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers
by: Jiasen Sun, et al.
Published: (2024-10-01)

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity
by: Jingfang Chen, et al.
Published: (2025-07-01)

Dysregulated lipids homeostasis disrupts CHAC1-mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer
by: Jingwen Chen, et al.
Published: (2025-07-01)

Nootkatone inhibits the progression of glioblastoma by activating the ATF4-CHOP-CHAC1 pathway
by: Qian Wang, et al.
Published: (2025-01-01)

Novel [3+2+1] Coordinated Iridium (III) Complexes for Hyperefficient Photodynamic Therapy
by: Siwei Zhang, et al.
Published: (2025-04-01)

Quercetin-loaded exosomes delivery system prevents myopia progression by targeting endoplasmic reticulum stress and ferroptosis in scleral fibroblasts
by: Lianghui Zhao, et al.
Published: (2025-06-01)

Deciphering sevoflurane-induced neurotoxicity: from isolated targets to intricate regulatory networks
by: Yue Shu, et al.
Published: (2025-08-01)

Theaflavin-3,3'-digallate alleviates glucolipotoxicity-induced insulin secretion dysfunction in pancreatic β-TC-6 cells and zebrafish via anti-ferroptotic mechanisms by activating SERCA2
by: Kaixi Wang, et al.
Published: (2025-04-01)

Connections Between Endoplasmic Reticulum Stress and Prognosis of Hepatocarcinoma
by: Ming Wu, et al.
Published: (2024-11-01)

The multi-omics analysis identifies a novel endoplasmic reticulum stress and immune related genes signature in lung adenocarcinoma
by: Danhe Huang, et al.
Published: (2025-07-01)

Mitochondria‐Associated Endoplasmic Reticulum Membranes in Human Health and Diseases
by: Yong Liu, et al.
Published: (2025-07-01)

Endoplasmic reticulum-mitochondria crosstalk: new mechanisms in the development of atherosclerosis
by: Mingxiao Li, et al.
Published: (2025-06-01)

Protein S-glutathionylation confers cellular resistance to ferroptosis induced by glutathione depletion
by: Yi Ju, et al.
Published: (2025-06-01)

Nanoparticle-mediated celastrol ER targeting delivery amplify immunogenic cell death in melanoma
by: Fengling Wang, et al.
Published: (2025-05-01)

Research hotspots and frontiers of endoplasmic reticulum in glomerular podocytes: a bibliometric and visual analysis from 2005 to 2023
by: Wang Junli, et al.
Published: (2025-01-01)

The endoplasmic reticulum stress-ferroptosis reciprocal signaling orchestrates anti-tumor effect of anlotinib in anaplastic thyroid cancer
by: Yehao Guo, et al.
Published: (2025-08-01)

Endoplasmic reticulum stress-related prognosis signature characterizes the immune landscape and predicts the prognosis of colon adenocarcinoma
by: Lichao Cao, et al.
Published: (2025-04-01)

Secretion of transthyretin: molecular mechanisms dependent on the endoplasmic reticulum
by: Jia Meng, et al.
Published: (2025-07-01)

CSE-8, a filamentous fungus-specific Shr3-like chaperone, facilitates endoplasmic reticulum exit of chitin synthase CHS-3 (class I) in Neurospora crassa
by: Samantha Verónica González-Téllez, et al.
Published: (2025-01-01)

Endoplasmic reticulum stress aggravates ferroptosis via PERK/ATF4/HSPA5 pathway in UUO-induced renal fibrosis
by: Zhigang Huang, et al.
Published: (2025-04-01)

Intracellular Membrane Contact Sites in Skeletal Muscle Cells
by: Matteo Serano, et al.
Published: (2025-01-01)

The structure and function of mitofusin 2 and its role in cardiovascular disease through mediating mitochondria-associated endoplasmic reticulum membranes
by: Yuhu Lv, et al.
Published: (2025-05-01)

Development and validation of a novel endoplasmic reticulum stress-related lncRNA signature in laryngeal squamous cell carcinoma
by: Xiazhi Pan, et al.
Published: (2025-04-01)

An integrated machine learning framework for developing and validating a prognostic risk model of gastric cancer based on endoplasmic reticulum stress-associated genes
by: Gang Wei, et al.
Published: (2025-03-01)

Protective effects and mechanisms of cynaroside on renal fibrosis in mice with unilateral ureteral obstruction
by: Ah Young Yang, et al.
Published: (2025-12-01)

Sigma-1 receptor exerts protective effects on ameliorating nephrolithiasis by modulating endoplasmic reticulum-mitochondrion association and inhibiting endoplasmic reticulum stress-induced apoptosis in renal tubular epithelial cells
by: Hu Ke, et al.
Published: (2024-12-01)

Effect of 1-DNJ on Oxidative Stress-Induced Apoptosis in Porcine Ovarian GCs Through Modulation of the PERK-ATF4/MFN2 Signaling Pathway
by: Wenwen Xing, et al.
Published: (2025-04-01)

Redox signaling-mediated S-glutathionylation of protein disulfide isomerase A1 initiates intrinsic apoptosis and contributes to accelerated aging
by: Zhi-Wei Ye, et al.
Published: (2025-09-01)

Different Proteostasis Mechanisms Facilitate the Assembly of Individual Components on the Chitin Synthase 3 Complex at the Endoplasmic Reticulum
by: Noelia Sánchez, et al.
Published: (2025-03-01)

Phosphorylated septin 3 delocalizes from the spine base and facilitates endoplasmic reticulum extension into spines via myosin-Va
by: Natsumi Ageta-Ishihara, et al.
Published: (2025-05-01)

Effects of Ire1 gene on virulence and pathogenicity of Candida albicans
by: Zhao Huihai, et al.
Published: (2025-04-01)

Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation
by: Jianhan He, et al.
Published: (2025-04-01)

Boanmycin overcomes bortezomib resistance by inducing DNA damage and endoplasmic reticulum functional impairment in multiple myeloma
by: Jin-Xing Wang, et al.
Published: (2025-01-01)

USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2α-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells
by: Lin Li, et al.
Published: (2025-05-01)

Endoplasmic Reticulum Stress: Triggers Microenvironmental Regulation and Drives Tumor Evolution
by: Chaosheng Peng, et al.
Published: (2025-03-01)

Lithium carbonate exposure disrupts neurodevelopment by perturbing primary cilia and ER homeostasis
by: Zhen Guan, et al.
Published: (2025-05-01)

Manganese Porphyrin Treatment Improves Redox Status Caused by Acute Compressive Spinal Cord Trauma
by: Raquel Vieira Niella, et al.
Published: (2025-05-01)

Endoplasmic reticulum stress contributes to insulin resistance in Hashimoto’s thyroiditis
by: Qing Zhou, et al.
Published: (2025-08-01)