Exosomes: new targets for understanding axon guidance in the developing central nervous system
Axon guidance is a key event in neural circuit development that drives the correct targeting of axons to their targets through long distances and unique patterns. Exosomes, extracellular vesicles that are smaller than 100 nm, are secreted by most cell types in the brain. Regulation of cell-cell comm...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1510862/full |
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| author | Mingyu Liu Mingyu Liu Teng Teng Teng Teng Teng Teng |
| author_facet | Mingyu Liu Mingyu Liu Teng Teng Teng Teng Teng Teng |
| author_sort | Mingyu Liu |
| collection | DOAJ |
| description | Axon guidance is a key event in neural circuit development that drives the correct targeting of axons to their targets through long distances and unique patterns. Exosomes, extracellular vesicles that are smaller than 100 nm, are secreted by most cell types in the brain. Regulation of cell-cell communication, neuroregeneration, and synapse formation by exosomes have been extensively studied. However, the interaction between exosomes and axon guidance molecules is poorly understood. This review summarizes the relationship between exosomes and canonical and non-canonical guidance cues and hypothesizes a possible model for exosomes mediating axon guidance between cells. The roles of exosomes in axon outgrowth, regeneration, and neurodevelopmental disorders are also reviewed, to discuss exosome-guidance interactions as potential clinical therapeutic targets. |
| format | Article |
| id | doaj-art-e5a2355d2cdf43338c93b5dea2871e8b |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-e5a2355d2cdf43338c93b5dea2871e8b2025-01-09T06:10:54ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-01-011210.3389/fcell.2024.15108621510862Exosomes: new targets for understanding axon guidance in the developing central nervous systemMingyu Liu0Mingyu Liu1Teng Teng2Teng Teng3Teng Teng4Key Laboratory of Tropical Translational Medicine and Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, ChinaSchool of Stomatology, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine and Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, ChinaSchool of Basic Medicine and Life Science, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, ChinaDepartment of Histology and Embryology, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, ChinaAxon guidance is a key event in neural circuit development that drives the correct targeting of axons to their targets through long distances and unique patterns. Exosomes, extracellular vesicles that are smaller than 100 nm, are secreted by most cell types in the brain. Regulation of cell-cell communication, neuroregeneration, and synapse formation by exosomes have been extensively studied. However, the interaction between exosomes and axon guidance molecules is poorly understood. This review summarizes the relationship between exosomes and canonical and non-canonical guidance cues and hypothesizes a possible model for exosomes mediating axon guidance between cells. The roles of exosomes in axon outgrowth, regeneration, and neurodevelopmental disorders are also reviewed, to discuss exosome-guidance interactions as potential clinical therapeutic targets.https://www.frontiersin.org/articles/10.3389/fcell.2024.1510862/fullaxon guidancecentral nervous system developmentexosomesneurodevelopmental disordersneuronal circuit formation |
| spellingShingle | Mingyu Liu Mingyu Liu Teng Teng Teng Teng Teng Teng Exosomes: new targets for understanding axon guidance in the developing central nervous system Frontiers in Cell and Developmental Biology axon guidance central nervous system development exosomes neurodevelopmental disorders neuronal circuit formation |
| title | Exosomes: new targets for understanding axon guidance in the developing central nervous system |
| title_full | Exosomes: new targets for understanding axon guidance in the developing central nervous system |
| title_fullStr | Exosomes: new targets for understanding axon guidance in the developing central nervous system |
| title_full_unstemmed | Exosomes: new targets for understanding axon guidance in the developing central nervous system |
| title_short | Exosomes: new targets for understanding axon guidance in the developing central nervous system |
| title_sort | exosomes new targets for understanding axon guidance in the developing central nervous system |
| topic | axon guidance central nervous system development exosomes neurodevelopmental disorders neuronal circuit formation |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1510862/full |
| work_keys_str_mv | AT mingyuliu exosomesnewtargetsforunderstandingaxonguidanceinthedevelopingcentralnervoussystem AT mingyuliu exosomesnewtargetsforunderstandingaxonguidanceinthedevelopingcentralnervoussystem AT tengteng exosomesnewtargetsforunderstandingaxonguidanceinthedevelopingcentralnervoussystem AT tengteng exosomesnewtargetsforunderstandingaxonguidanceinthedevelopingcentralnervoussystem AT tengteng exosomesnewtargetsforunderstandingaxonguidanceinthedevelopingcentralnervoussystem |