Therapeutic potential of plant-derived small extracellular vesicles in sepsis: A network meta-analysis
Sepsis is a life-threatening condition characterized by systemic inflammation and multi-organ dysfunction. Plant-derived small extracellular vesicles (sEVs) have emerged as promising therapeutic agents due to their antioxidant, anti-inflammatory, and immunomodulatory properties. This study conducted...
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Elsevier
2025-07-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825002208 |
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| author | Wen-Yi Lai Ching-Wei Chuang Yu-Chen Huang Chun-Jen Huang |
| author_facet | Wen-Yi Lai Ching-Wei Chuang Yu-Chen Huang Chun-Jen Huang |
| author_sort | Wen-Yi Lai |
| collection | DOAJ |
| description | Sepsis is a life-threatening condition characterized by systemic inflammation and multi-organ dysfunction. Plant-derived small extracellular vesicles (sEVs) have emerged as promising therapeutic agents due to their antioxidant, anti-inflammatory, and immunomodulatory properties. This study conducted a network meta-analysis to identify the most effective plant-derived sEVs for reducing sepsis-induced inflammation and oxidative stress. The analysis included 13 studies evaluating 10 plant-derived sEVs in sepsis-mimicking conditions, with primary outcomes focused on cytokine levels and reactive oxygen species (ROS) production in vitro and in vivo. Secondary outcomes included nuclear factor erythroid 2–related factor 2 (Nrf2) expression and cell viability. The study protocol was registered with PROSPERO (CRD420251011005). Ginger-derived sEVs were identified as the most effective, significantly reducing pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor-α), increasing the anti-inflammatory cytokine (interleukin-10), and suppressing ROS production. They also enhanced Nrf2 expression and improved cell viability, highlighting their role in antioxidant defense and cytoprotection. In conclusion, ginger-derived sEVs are the most effective plant-derived sEVs for mitigating sepsis-induced inflammation and oxidation in both in vitro and in vivo sepsis-mimicking models. |
| format | Article |
| id | doaj-art-e5a1a533c9a247f1b530102b090ccc5f |
| institution | OA Journals |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-e5a1a533c9a247f1b530102b090ccc5f2025-08-20T02:34:35ZengElsevierPharmacological Research1096-11862025-07-0121710779510.1016/j.phrs.2025.107795Therapeutic potential of plant-derived small extracellular vesicles in sepsis: A network meta-analysisWen-Yi Lai0Ching-Wei Chuang1Yu-Chen Huang2Chun-Jen Huang3Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Integrative Research Center for Critical Care, Wan Fang Hospital, Taipei Medical University, Taipei, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Integrative Research Center for Critical Care, Wan Fang Hospital, Taipei Medical University, Taipei, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Integrative Research Center for Critical Care, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Correspondence to: Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, No.250, Wuxing St., Xinyi Dist., Taipei City 110, Taiwan.Sepsis is a life-threatening condition characterized by systemic inflammation and multi-organ dysfunction. Plant-derived small extracellular vesicles (sEVs) have emerged as promising therapeutic agents due to their antioxidant, anti-inflammatory, and immunomodulatory properties. This study conducted a network meta-analysis to identify the most effective plant-derived sEVs for reducing sepsis-induced inflammation and oxidative stress. The analysis included 13 studies evaluating 10 plant-derived sEVs in sepsis-mimicking conditions, with primary outcomes focused on cytokine levels and reactive oxygen species (ROS) production in vitro and in vivo. Secondary outcomes included nuclear factor erythroid 2–related factor 2 (Nrf2) expression and cell viability. The study protocol was registered with PROSPERO (CRD420251011005). Ginger-derived sEVs were identified as the most effective, significantly reducing pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor-α), increasing the anti-inflammatory cytokine (interleukin-10), and suppressing ROS production. They also enhanced Nrf2 expression and improved cell viability, highlighting their role in antioxidant defense and cytoprotection. In conclusion, ginger-derived sEVs are the most effective plant-derived sEVs for mitigating sepsis-induced inflammation and oxidation in both in vitro and in vivo sepsis-mimicking models.http://www.sciencedirect.com/science/article/pii/S1043661825002208SepsisPlant-derived small extracellular vesiclesImmune regulationNetwork meta-analysis |
| spellingShingle | Wen-Yi Lai Ching-Wei Chuang Yu-Chen Huang Chun-Jen Huang Therapeutic potential of plant-derived small extracellular vesicles in sepsis: A network meta-analysis Pharmacological Research Sepsis Plant-derived small extracellular vesicles Immune regulation Network meta-analysis |
| title | Therapeutic potential of plant-derived small extracellular vesicles in sepsis: A network meta-analysis |
| title_full | Therapeutic potential of plant-derived small extracellular vesicles in sepsis: A network meta-analysis |
| title_fullStr | Therapeutic potential of plant-derived small extracellular vesicles in sepsis: A network meta-analysis |
| title_full_unstemmed | Therapeutic potential of plant-derived small extracellular vesicles in sepsis: A network meta-analysis |
| title_short | Therapeutic potential of plant-derived small extracellular vesicles in sepsis: A network meta-analysis |
| title_sort | therapeutic potential of plant derived small extracellular vesicles in sepsis a network meta analysis |
| topic | Sepsis Plant-derived small extracellular vesicles Immune regulation Network meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825002208 |
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