Polygonatum polysaccharides as gut microbiota modulators: implications for autophagy-dependent PD-L1 clearance in cancer immunotherapy
The purpose of this review article is to examine the biotransformation of Polygonatum polysaccharides and the role that gut microbiota plays in that biotransformation. In the past years, PD-L1 has come under much attention as an immune checkpoint target and autophagy-lysosomal mediated degradation o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1612644/full |
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| author | Yongjie Li Yongjie Li Feng Jiang Ting Wang Min Zeng |
| author_facet | Yongjie Li Yongjie Li Feng Jiang Ting Wang Min Zeng |
| author_sort | Yongjie Li |
| collection | DOAJ |
| description | The purpose of this review article is to examine the biotransformation of Polygonatum polysaccharides and the role that gut microbiota plays in that biotransformation. In the past years, PD-L1 has come under much attention as an immune checkpoint target and autophagy-lysosomal mediated degradation of PD-L1 provides new approaches for cancer immunotherapy. This review explores how gut microbiota-mediated biotransformation of Polygonatum polysaccharides may influence PD-L1 expression and degradation, potentially offering a novel approach to enhancing cancer immunotherapy. This synthesis of information highlights the complex relationship between foods, microbiota, and the immune system and supports the emerging idea that targeting microbiota-mediated metabolism and the immune response may be beneficial to improve cancer therapeutics. |
| format | Article |
| id | doaj-art-e5a0fde1ff254477a13aebea6d709fb9 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-e5a0fde1ff254477a13aebea6d709fb92025-08-20T03:32:09ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-06-011210.3389/fnut.2025.16126441612644Polygonatum polysaccharides as gut microbiota modulators: implications for autophagy-dependent PD-L1 clearance in cancer immunotherapyYongjie Li0Yongjie Li1Feng Jiang2Ting Wang3Min Zeng4School of Pharmacy, Shaoyang University, Shaoyang, Hunan, ChinaSouthwest Hunan Research Center of Engineering for Development and Utilization of Traditional Chinese Medicine, Shaoyang, Hunan, ChinaDepartment of Nutrition, Taizhou Central Hospital, Taizhou, Zhejiang, ChinaThe Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaThe Affiliated Shaoyang Hospital, Hengyang Medical School, University of South China, Shaoyang, Hunan, ChinaThe purpose of this review article is to examine the biotransformation of Polygonatum polysaccharides and the role that gut microbiota plays in that biotransformation. In the past years, PD-L1 has come under much attention as an immune checkpoint target and autophagy-lysosomal mediated degradation of PD-L1 provides new approaches for cancer immunotherapy. This review explores how gut microbiota-mediated biotransformation of Polygonatum polysaccharides may influence PD-L1 expression and degradation, potentially offering a novel approach to enhancing cancer immunotherapy. This synthesis of information highlights the complex relationship between foods, microbiota, and the immune system and supports the emerging idea that targeting microbiota-mediated metabolism and the immune response may be beneficial to improve cancer therapeutics.https://www.frontiersin.org/articles/10.3389/fnut.2025.1612644/fullgut microbiotaPolygonatum polysaccharidesautophagylysosomePD-L1 |
| spellingShingle | Yongjie Li Yongjie Li Feng Jiang Ting Wang Min Zeng Polygonatum polysaccharides as gut microbiota modulators: implications for autophagy-dependent PD-L1 clearance in cancer immunotherapy Frontiers in Nutrition gut microbiota Polygonatum polysaccharides autophagy lysosome PD-L1 |
| title | Polygonatum polysaccharides as gut microbiota modulators: implications for autophagy-dependent PD-L1 clearance in cancer immunotherapy |
| title_full | Polygonatum polysaccharides as gut microbiota modulators: implications for autophagy-dependent PD-L1 clearance in cancer immunotherapy |
| title_fullStr | Polygonatum polysaccharides as gut microbiota modulators: implications for autophagy-dependent PD-L1 clearance in cancer immunotherapy |
| title_full_unstemmed | Polygonatum polysaccharides as gut microbiota modulators: implications for autophagy-dependent PD-L1 clearance in cancer immunotherapy |
| title_short | Polygonatum polysaccharides as gut microbiota modulators: implications for autophagy-dependent PD-L1 clearance in cancer immunotherapy |
| title_sort | polygonatum polysaccharides as gut microbiota modulators implications for autophagy dependent pd l1 clearance in cancer immunotherapy |
| topic | gut microbiota Polygonatum polysaccharides autophagy lysosome PD-L1 |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1612644/full |
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