The risk of mother-to-child transmission of hepatitis B virus infection in Ethiopia: A systematic review and meta-analysis
Introduction: Mother-to-child transmission (MTCT) of hepatitis B virus (HBV) is a predominant route of infection for children in Ethiopia. No study has so far reported a nationwide estimate of the risk of MTCT of HBV. We conducted a meta-analysis of surveys and estimated the pooled risk of MTCT of...
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The Journal of Infection in Developing Countries
2023-06-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/17931 |
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| author | Belaynew W Taye Girum Meseret Ayenew Zewdu Wasie Taye Melashu Balew Eden Bishaw Taye |
| author_facet | Belaynew W Taye Girum Meseret Ayenew Zewdu Wasie Taye Melashu Balew Eden Bishaw Taye |
| author_sort | Belaynew W Taye |
| collection | DOAJ |
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Introduction: Mother-to-child transmission (MTCT) of hepatitis B virus (HBV) is a predominant route of infection for children in Ethiopia. No study has so far reported a nationwide estimate of the risk of MTCT of HBV. We conducted a meta-analysis of surveys and estimated the pooled risk of MTCT of HBV in the context of human immunodeficiency virus (HIV) infection.
Methodology: We searched PubMed, EMBASE, Web of Science, Africa Index Medicus, and Google Scholar databases for peer-reviewed articles. The pooled risk of MTCT of HBV was estimated using the DerSimonian-Laird technique with logit transformed proportions and statistical heterogeneity was estimated using I2 statistic, which was explored by subgroup and meta-regression analyses.
Results: The overall pooled risk of MTCT of HBV in Ethiopia was 25.5% (95% CI, 13.4%–42.9%). In women without HIV infection, the risk of MTCT of HBV was 20.7% (95% CI 2.8%–70.4%), and 32.2% (95% CI 28.1%–36.7%) in women with HIV infection. After excluding the outlier study, the risk of MTCT of HBV in studies that included only HIV negative women was 9.4% (95% CI, 5.1%–16.6%).
Conclusions: The risk of MTCT of HBV in Ethiopia widely varied by HBV/HIV coinfection. A sustainable control and elimination of HBV in Ethiopia requires improved access to birth-dose HBV vaccine and implement immunoglobulin prophylaxis for exposed infants. Given the limited health resources in Ethiopia, prenatal antiviral prophylaxis integrated with antenatal care may be a cost-effective approach to significantly reduce the risk of MTCT of HBV.
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| format | Article |
| id | doaj-art-e5a077761bbc4ae880fb08f577adc7f2 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-e5a077761bbc4ae880fb08f577adc7f22025-08-20T03:52:42ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802023-06-01170610.3855/jidc.17931The risk of mother-to-child transmission of hepatitis B virus infection in Ethiopia: A systematic review and meta-analysisBelaynew W Taye0Girum Meseret Ayenew1Zewdu Wasie Taye2Melashu Balew3Eden Bishaw Taye4Telethon Kids Institute, Wesfarmers Centre of Vaccines and Infectious Diseases, Infectious Disease Epidemiology Team, Perth, AustraliaAmhara Public Health Institute, Bahir Dar, Amhara, EthiopiaHealth Department, International Red Cross Society, North Gondar, Amhara, EthiopiaAmhara Public Health Institute, Bahir Dar, Amhara, EthiopiaCollege of Medicine and Health Sciences, The University of Gondar, Gondar, Ethiopia Introduction: Mother-to-child transmission (MTCT) of hepatitis B virus (HBV) is a predominant route of infection for children in Ethiopia. No study has so far reported a nationwide estimate of the risk of MTCT of HBV. We conducted a meta-analysis of surveys and estimated the pooled risk of MTCT of HBV in the context of human immunodeficiency virus (HIV) infection. Methodology: We searched PubMed, EMBASE, Web of Science, Africa Index Medicus, and Google Scholar databases for peer-reviewed articles. The pooled risk of MTCT of HBV was estimated using the DerSimonian-Laird technique with logit transformed proportions and statistical heterogeneity was estimated using I2 statistic, which was explored by subgroup and meta-regression analyses. Results: The overall pooled risk of MTCT of HBV in Ethiopia was 25.5% (95% CI, 13.4%–42.9%). In women without HIV infection, the risk of MTCT of HBV was 20.7% (95% CI 2.8%–70.4%), and 32.2% (95% CI 28.1%–36.7%) in women with HIV infection. After excluding the outlier study, the risk of MTCT of HBV in studies that included only HIV negative women was 9.4% (95% CI, 5.1%–16.6%). Conclusions: The risk of MTCT of HBV in Ethiopia widely varied by HBV/HIV coinfection. A sustainable control and elimination of HBV in Ethiopia requires improved access to birth-dose HBV vaccine and implement immunoglobulin prophylaxis for exposed infants. Given the limited health resources in Ethiopia, prenatal antiviral prophylaxis integrated with antenatal care may be a cost-effective approach to significantly reduce the risk of MTCT of HBV. https://jidc.org/index.php/journal/article/view/17931eliminationmother-to-child transmissionhepatitis Bmeta-analysismeta-regression |
| spellingShingle | Belaynew W Taye Girum Meseret Ayenew Zewdu Wasie Taye Melashu Balew Eden Bishaw Taye The risk of mother-to-child transmission of hepatitis B virus infection in Ethiopia: A systematic review and meta-analysis Journal of Infection in Developing Countries elimination mother-to-child transmission hepatitis B meta-analysis meta-regression |
| title | The risk of mother-to-child transmission of hepatitis B virus infection in Ethiopia: A systematic review and meta-analysis |
| title_full | The risk of mother-to-child transmission of hepatitis B virus infection in Ethiopia: A systematic review and meta-analysis |
| title_fullStr | The risk of mother-to-child transmission of hepatitis B virus infection in Ethiopia: A systematic review and meta-analysis |
| title_full_unstemmed | The risk of mother-to-child transmission of hepatitis B virus infection in Ethiopia: A systematic review and meta-analysis |
| title_short | The risk of mother-to-child transmission of hepatitis B virus infection in Ethiopia: A systematic review and meta-analysis |
| title_sort | risk of mother to child transmission of hepatitis b virus infection in ethiopia a systematic review and meta analysis |
| topic | elimination mother-to-child transmission hepatitis B meta-analysis meta-regression |
| url | https://jidc.org/index.php/journal/article/view/17931 |
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