HTLV-1 infection and microRNAs: unraveling the complex crosstalk
Abstract Human T-cell leukemia virus type 1 (HTLV-1) retrovirus that infects millions of individuals worldwide, have caused severe diseases like adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Despite extensive research efforts, the unde...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | Infectious Agents and Cancer |
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| Online Access: | https://doi.org/10.1186/s13027-025-00658-y |
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| _version_ | 1850270901213331456 |
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| author | Fahime Edalat Arash Letafati Tanin kaghazchi Mahdieh Sadeghi Ali Taheri Alireza Shikki Samira Hossein Garkani Mehdi Afrozi Mehdi Norouzi Sayed-Hamidreza Mozhgani |
| author_facet | Fahime Edalat Arash Letafati Tanin kaghazchi Mahdieh Sadeghi Ali Taheri Alireza Shikki Samira Hossein Garkani Mehdi Afrozi Mehdi Norouzi Sayed-Hamidreza Mozhgani |
| author_sort | Fahime Edalat |
| collection | DOAJ |
| description | Abstract Human T-cell leukemia virus type 1 (HTLV-1) retrovirus that infects millions of individuals worldwide, have caused severe diseases like adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Despite extensive research efforts, the underlying mechanisms leading to HTLV-1 pathogenesis remain incompletely understood. New research has revealed that microRNAs (miRNAs) play a crucial role in the complex interplay between HTLV-1 infection and host cellular responses. This review highlights the multifaceted interactions between HTLV-1 and miRNAs, encompassing both viral manipulation of cellular miRNA networks and host miRNA-mediated responses. Gaining a comprehensive understanding of the complex interconnection between HTLV-1 infection and miRNAs provides a significant opportunity for discovering innovative therapeutic approaches and creating advanced diagnostic tools aimed in HTLV-1 treatment. |
| format | Article |
| id | doaj-art-e59c660a2d6e4429888092912a9edac1 |
| institution | OA Journals |
| issn | 1750-9378 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj-art-e59c660a2d6e4429888092912a9edac12025-08-20T01:52:24ZengBMCInfectious Agents and Cancer1750-93782025-05-012011610.1186/s13027-025-00658-yHTLV-1 infection and microRNAs: unraveling the complex crosstalkFahime Edalat0Arash Letafati1Tanin kaghazchi2Mahdieh Sadeghi3Ali Taheri4Alireza Shikki5Samira Hossein Garkani6Mehdi Afrozi7Mehdi Norouzi8Sayed-Hamidreza Mozhgani9Autophagy Research Center, Shiraz University of Medical ScienceDepartment of Virology, School of Public Health, Tehran University of Medical SciencesStudent Scientific Research Center (SSRC), Tehran University of Medical SciencesStudent Scientific Research Center (SSRC), Tehran University of Medical SciencesDepartment of Immunology, Shahed UniversityDepartment of Microbiology, Shahed UniversityStudent Scientific Research Center (SSRC), Tehran University of Medical SciencesStudent Scientific Research Center (SSRC), Tehran University of Medical SciencesDepartment of Virology, School of Public Health, Tehran University of Medical SciencesDepartment of Microbiology and Virology, School of Medicine, Alborz University of Medical SciencesAbstract Human T-cell leukemia virus type 1 (HTLV-1) retrovirus that infects millions of individuals worldwide, have caused severe diseases like adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Despite extensive research efforts, the underlying mechanisms leading to HTLV-1 pathogenesis remain incompletely understood. New research has revealed that microRNAs (miRNAs) play a crucial role in the complex interplay between HTLV-1 infection and host cellular responses. This review highlights the multifaceted interactions between HTLV-1 and miRNAs, encompassing both viral manipulation of cellular miRNA networks and host miRNA-mediated responses. Gaining a comprehensive understanding of the complex interconnection between HTLV-1 infection and miRNAs provides a significant opportunity for discovering innovative therapeutic approaches and creating advanced diagnostic tools aimed in HTLV-1 treatment.https://doi.org/10.1186/s13027-025-00658-yHTLV-1MicroRNAHAM/TSPATLLCancerNeurodegenerative |
| spellingShingle | Fahime Edalat Arash Letafati Tanin kaghazchi Mahdieh Sadeghi Ali Taheri Alireza Shikki Samira Hossein Garkani Mehdi Afrozi Mehdi Norouzi Sayed-Hamidreza Mozhgani HTLV-1 infection and microRNAs: unraveling the complex crosstalk Infectious Agents and Cancer HTLV-1 MicroRNA HAM/TSP ATLL Cancer Neurodegenerative |
| title | HTLV-1 infection and microRNAs: unraveling the complex crosstalk |
| title_full | HTLV-1 infection and microRNAs: unraveling the complex crosstalk |
| title_fullStr | HTLV-1 infection and microRNAs: unraveling the complex crosstalk |
| title_full_unstemmed | HTLV-1 infection and microRNAs: unraveling the complex crosstalk |
| title_short | HTLV-1 infection and microRNAs: unraveling the complex crosstalk |
| title_sort | htlv 1 infection and micrornas unraveling the complex crosstalk |
| topic | HTLV-1 MicroRNA HAM/TSP ATLL Cancer Neurodegenerative |
| url | https://doi.org/10.1186/s13027-025-00658-y |
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