Severe RSV Infection Occurring at the End of Nirsevimab’s Protection Window: A Case Report
We present the case of a five-month-old late preterm infant who developed severe bronchiolitis caused by respiratory syncytial virus, requiring hospitalisation and high-flow nasal cannula support. This occurred 142 days after the infant received a single dose of nirsevimab as part of the regional im...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/crpe/3334926 |
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| author | Sebastiano Mazza Benedetta Ciccone Anna Maddalena D’Apolito Caterina Petruccelli Dalila Tedeschi Francesca Ippedico Marianna Lauriola Stefano Aniello Ferrante Claudia Baiardi Anna Calò Francesca Fortunato Angelo Campanozzi |
| author_facet | Sebastiano Mazza Benedetta Ciccone Anna Maddalena D’Apolito Caterina Petruccelli Dalila Tedeschi Francesca Ippedico Marianna Lauriola Stefano Aniello Ferrante Claudia Baiardi Anna Calò Francesca Fortunato Angelo Campanozzi |
| author_sort | Sebastiano Mazza |
| collection | DOAJ |
| description | We present the case of a five-month-old late preterm infant who developed severe bronchiolitis caused by respiratory syncytial virus, requiring hospitalisation and high-flow nasal cannula support. This occurred 142 days after the infant received a single dose of nirsevimab as part of the regional immunisation campaign, administered on day three of life. The patient had no underlying conditions. PCR testing revealed RSV A and human rhinovirus co-infection. The infant improved with supportive care and was discharged in stable condition after 8 days. This case raises concerns about possible waning immunity near the end of the expected 150-day protection window of nirsevimab, particularly in infants immunised early in the RSV season. Additionally, co-infection with hRV may have contributed to disease severity. Although nirsevimab remains a highly effective preventive tool, this case highlights the potential for waning immunity near the end of the protection window and suggests that ongoing surveillance is essential to optimize immunization strategies, particularly in regions with prolonged RSV seasons. |
| format | Article |
| id | doaj-art-e59a8355a9b44b7bb35472a5f5e3f6cf |
| institution | Kabale University |
| issn | 2090-6811 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-e59a8355a9b44b7bb35472a5f5e3f6cf2025-08-20T03:31:30ZengWileyCase Reports in Pediatrics2090-68112025-01-01202510.1155/crpe/3334926Severe RSV Infection Occurring at the End of Nirsevimab’s Protection Window: A Case ReportSebastiano Mazza0Benedetta Ciccone1Anna Maddalena D’Apolito2Caterina Petruccelli3Dalila Tedeschi4Francesca Ippedico5Marianna Lauriola6Stefano Aniello Ferrante7Claudia Baiardi8Anna Calò9Francesca Fortunato10Angelo Campanozzi11Dipartimento Donna e BambinoDipartimento Donna e BambinoDipartimento Donna e BambinoDipartimento Donna e BambinoDipartimento Donna e BambinoDipartimento Donna e BambinoDipartimento Donna e BambinoDipartimento Donna e BambinoDipartimento Donna e BambinoDipartimento Donna e BambinoDipartimento di Scienze Mediche e ChirurgicheDipartimento Donna e BambinoWe present the case of a five-month-old late preterm infant who developed severe bronchiolitis caused by respiratory syncytial virus, requiring hospitalisation and high-flow nasal cannula support. This occurred 142 days after the infant received a single dose of nirsevimab as part of the regional immunisation campaign, administered on day three of life. The patient had no underlying conditions. PCR testing revealed RSV A and human rhinovirus co-infection. The infant improved with supportive care and was discharged in stable condition after 8 days. This case raises concerns about possible waning immunity near the end of the expected 150-day protection window of nirsevimab, particularly in infants immunised early in the RSV season. Additionally, co-infection with hRV may have contributed to disease severity. Although nirsevimab remains a highly effective preventive tool, this case highlights the potential for waning immunity near the end of the protection window and suggests that ongoing surveillance is essential to optimize immunization strategies, particularly in regions with prolonged RSV seasons.http://dx.doi.org/10.1155/crpe/3334926 |
| spellingShingle | Sebastiano Mazza Benedetta Ciccone Anna Maddalena D’Apolito Caterina Petruccelli Dalila Tedeschi Francesca Ippedico Marianna Lauriola Stefano Aniello Ferrante Claudia Baiardi Anna Calò Francesca Fortunato Angelo Campanozzi Severe RSV Infection Occurring at the End of Nirsevimab’s Protection Window: A Case Report Case Reports in Pediatrics |
| title | Severe RSV Infection Occurring at the End of Nirsevimab’s Protection Window: A Case Report |
| title_full | Severe RSV Infection Occurring at the End of Nirsevimab’s Protection Window: A Case Report |
| title_fullStr | Severe RSV Infection Occurring at the End of Nirsevimab’s Protection Window: A Case Report |
| title_full_unstemmed | Severe RSV Infection Occurring at the End of Nirsevimab’s Protection Window: A Case Report |
| title_short | Severe RSV Infection Occurring at the End of Nirsevimab’s Protection Window: A Case Report |
| title_sort | severe rsv infection occurring at the end of nirsevimab s protection window a case report |
| url | http://dx.doi.org/10.1155/crpe/3334926 |
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