The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activation.

The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activation.

<h4>Background</h4>Adequate termination of an immune response is as important as the induction of an appropriate response. CD46, a regulator of complement activity, promotes T cell activation and differentiation towards a regulatory Tr1 phenotype. This Tr1 differentiation pathway is defe...

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Bibliographic Details
Main Authors: Siobhan Ni Choileain, Nathan J Weyand, Christian Neumann, Joelle Thomas, Magdalene So, Anne L Astier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016287&type=printable
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