Multifaceted roles of SUMO in DNA metabolism
Sumoylation, a process in which SUMO (small ubiquitin like modifier) is conjugated to target proteins, emerges as a post-translational modification that mediates protein−protein interactions, protein complex assembly, and localization of target proteins. The coordinated actions of SUMO ligases, prot...
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| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Nucleus |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19491034.2024.2398450 |
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| author | Yee Mon Thu |
| author_facet | Yee Mon Thu |
| author_sort | Yee Mon Thu |
| collection | DOAJ |
| description | Sumoylation, a process in which SUMO (small ubiquitin like modifier) is conjugated to target proteins, emerges as a post-translational modification that mediates protein−protein interactions, protein complex assembly, and localization of target proteins. The coordinated actions of SUMO ligases, proteases, and SUMO-targeted ubiquitin ligases determine the net result of sumoylation. It is well established that sumoylation can somewhat promiscuously target proteins in groups as well as selectively target individual proteins. Through changing protein dynamics, sumoylation orchestrates multi-step processes in chromatin biology. Sumoylation influences various steps of mitosis, DNA replication, DNA damage repair, and pathways protecting chromosome integrity. This review highlights examples of SUMO-regulated nuclear processes to provide mechanistic views of sumoylation in DNA metabolism. |
| format | Article |
| id | doaj-art-e595a963d8a5423483a6638e263a94cb |
| institution | OA Journals |
| issn | 1949-1034 1949-1042 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Nucleus |
| spelling | doaj-art-e595a963d8a5423483a6638e263a94cb2025-08-20T02:30:42ZengTaylor & Francis GroupNucleus1949-10341949-10422024-12-0115110.1080/19491034.2024.2398450Multifaceted roles of SUMO in DNA metabolismYee Mon Thu0Department of Biology, Colby College, Waterville, ME, USASumoylation, a process in which SUMO (small ubiquitin like modifier) is conjugated to target proteins, emerges as a post-translational modification that mediates protein−protein interactions, protein complex assembly, and localization of target proteins. The coordinated actions of SUMO ligases, proteases, and SUMO-targeted ubiquitin ligases determine the net result of sumoylation. It is well established that sumoylation can somewhat promiscuously target proteins in groups as well as selectively target individual proteins. Through changing protein dynamics, sumoylation orchestrates multi-step processes in chromatin biology. Sumoylation influences various steps of mitosis, DNA replication, DNA damage repair, and pathways protecting chromosome integrity. This review highlights examples of SUMO-regulated nuclear processes to provide mechanistic views of sumoylation in DNA metabolism.https://www.tandfonline.com/doi/10.1080/19491034.2024.2398450Chromatin regulationDNA damagegenome instabilitypost-translational modificationSUMO |
| spellingShingle | Yee Mon Thu Multifaceted roles of SUMO in DNA metabolism Nucleus Chromatin regulation DNA damage genome instability post-translational modification SUMO |
| title | Multifaceted roles of SUMO in DNA metabolism |
| title_full | Multifaceted roles of SUMO in DNA metabolism |
| title_fullStr | Multifaceted roles of SUMO in DNA metabolism |
| title_full_unstemmed | Multifaceted roles of SUMO in DNA metabolism |
| title_short | Multifaceted roles of SUMO in DNA metabolism |
| title_sort | multifaceted roles of sumo in dna metabolism |
| topic | Chromatin regulation DNA damage genome instability post-translational modification SUMO |
| url | https://www.tandfonline.com/doi/10.1080/19491034.2024.2398450 |
| work_keys_str_mv | AT yeemonthu multifacetedrolesofsumoindnametabolism |