Improvement of Impaired Memory in Mice by Taurine
Taurine was extracted from Pegasus later-narius Cuvier to study its effects on learning and memory in mice. Mice were treated with different doses of taurine (10 mg/kg, 20 mg/kg, 40 mg/kg). The mice were treated with various chemical agents (pentobarbital, cycloheximide, sodium nitrite, alcohol) to...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2000.245 |
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| Summary: | Taurine was extracted from Pegasus later-narius Cuvier
to study its effects on learning and
memory in mice. Mice were treated with different
doses of taurine (10 mg/kg, 20 mg/kg, 40 mg/kg).
The mice were treated with various chemical
agents (pentobarbital, cycloheximide, sodium
nitrite, alcohol) to disrupt the normal memory
process. We measured the effect of taurine on
step-down latency (SDL) and escape latency (EL)
in a passive avoidance task after 10 or 30 days.
Treatment with taurine alone did not change
either SDL or EL. Taurine protected mice .from
the memory disruption induced by alcohol,
pentobarbital, sodium nitrite, and cycloheximide
but had no obvious effect on motor coordination,
exploratory activity, or locomotor activity as
measured using the rota-rod test and the hole
board test. We conclude that taurine can be
effective in attenuating the amnesia produced
by alcohol, pentobarbital, cycloheximide, and
sodium nitrite without compromising the
behavioral aspects of the animals tested. |
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| ISSN: | 2090-5904 1687-5443 |