The varied Q creatinine in multi ethnics population and impact of adopting three different estimated glomerular filtration rates based on creatinine in adult populations: a call for performance validation
BackgroundThe determination of kidney function is commonly done by estimating the glomerular filtration rate (eGFR) using serum creatinine levels. Various eGFR formulas, including the recently developed European Kidney Function Consortium (EKFC) and the Chronic Kidney Disease Epidemiology Collaborat...
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Frontiers Media S.A.
2025-03-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1467503/full |
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| author | Ferdy Royland Marpaung Santi Wulan Purnami Shofi Andari Ali Rohman Reny I’tishom Hari Basuki Notobroto Jusak Nugraha Risky Vitria Prasetyo Djoko Santoso Etienne Cavalier Aryati Aryati |
| author_facet | Ferdy Royland Marpaung Santi Wulan Purnami Shofi Andari Ali Rohman Reny I’tishom Hari Basuki Notobroto Jusak Nugraha Risky Vitria Prasetyo Djoko Santoso Etienne Cavalier Aryati Aryati |
| author_sort | Ferdy Royland Marpaung |
| collection | DOAJ |
| description | BackgroundThe determination of kidney function is commonly done by estimating the glomerular filtration rate (eGFR) using serum creatinine levels. Various eGFR formulas, including the recently developed European Kidney Function Consortium (EKFC) and the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI), have been adopted and are commonly utilized in clinical settings. Nevertheless, the extent of acceptance among these formulations in the multi ethnics populace is still undetermined. Thus, this study aimed to evaluate the performance of these formulations across different glomerular filtration rate categories in the adult population.MethodsThe research involved a total of 9,557 individuals (median age of 40 years and 85% being male) who underwent routine medical examinations. Enzymatic or modified Jaffe techniques were employed to measure serum creatinine levels. The CKD-EPI2009 eGFR was employed as corresponding GFR in the comparisons. The Bland–Altman method was used to determine the average discrepancies and 95% confidence intervals of eGFR between each formula. Ultimately, in order to compare the equations, Lin’s correlation coefficients were calculated for various eGFR categories.ResultsThe median creatinine level in the different island population showed variability. The CKD-EPI 2009 as well as different equations showed categorical agreement within the range of 91.42 to 92.77%. The correlations between CKD-EPI2009 and CKD-EPI 2021 and EKFC were 0.998 and 0.79, respectively (p < 0.001).ConclusionA substantial variation in creatinine and eGFR assessment were observed among different eGFR analysis for the adult population. Prospective study in various clinical contexts using measured GFR is essential to validate eGFR. |
| format | Article |
| id | doaj-art-e594a125eafd4981a13b051873a7c1df |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-e594a125eafd4981a13b051873a7c1df2025-08-20T03:39:57ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-03-011210.3389/fmed.2025.14675031467503The varied Q creatinine in multi ethnics population and impact of adopting three different estimated glomerular filtration rates based on creatinine in adult populations: a call for performance validationFerdy Royland Marpaung0Santi Wulan Purnami1Shofi Andari2Ali Rohman3Reny I’tishom4Hari Basuki Notobroto5Jusak Nugraha6Risky Vitria Prasetyo7Djoko Santoso8Etienne Cavalier9Aryati Aryati10Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Statistics, Institut Teknologi Sepuluh Nopember, Surabaya, IndonesiaDepartment of Statistics, Institut Teknologi Sepuluh Nopember, Surabaya, IndonesiaDepartment of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaDepartment of Biomedical Science, Universitas Airlangga, Surabaya, IndonesiaFaculty of Public Health, Universitas Airlangga, Surabaya, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Clinical Chemistry, University of Liège, CIRM, CHU Sart Tilman, Liège, BelgiumDepartment of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaBackgroundThe determination of kidney function is commonly done by estimating the glomerular filtration rate (eGFR) using serum creatinine levels. Various eGFR formulas, including the recently developed European Kidney Function Consortium (EKFC) and the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI), have been adopted and are commonly utilized in clinical settings. Nevertheless, the extent of acceptance among these formulations in the multi ethnics populace is still undetermined. Thus, this study aimed to evaluate the performance of these formulations across different glomerular filtration rate categories in the adult population.MethodsThe research involved a total of 9,557 individuals (median age of 40 years and 85% being male) who underwent routine medical examinations. Enzymatic or modified Jaffe techniques were employed to measure serum creatinine levels. The CKD-EPI2009 eGFR was employed as corresponding GFR in the comparisons. The Bland–Altman method was used to determine the average discrepancies and 95% confidence intervals of eGFR between each formula. Ultimately, in order to compare the equations, Lin’s correlation coefficients were calculated for various eGFR categories.ResultsThe median creatinine level in the different island population showed variability. The CKD-EPI 2009 as well as different equations showed categorical agreement within the range of 91.42 to 92.77%. The correlations between CKD-EPI2009 and CKD-EPI 2021 and EKFC were 0.998 and 0.79, respectively (p < 0.001).ConclusionA substantial variation in creatinine and eGFR assessment were observed among different eGFR analysis for the adult population. Prospective study in various clinical contexts using measured GFR is essential to validate eGFR.https://www.frontiersin.org/articles/10.3389/fmed.2025.1467503/fullcreatinineQ creatinineEGFRkidney functionnon-communicable disease |
| spellingShingle | Ferdy Royland Marpaung Santi Wulan Purnami Shofi Andari Ali Rohman Reny I’tishom Hari Basuki Notobroto Jusak Nugraha Risky Vitria Prasetyo Djoko Santoso Etienne Cavalier Aryati Aryati The varied Q creatinine in multi ethnics population and impact of adopting three different estimated glomerular filtration rates based on creatinine in adult populations: a call for performance validation Frontiers in Medicine creatinine Q creatinine EGFR kidney function non-communicable disease |
| title | The varied Q creatinine in multi ethnics population and impact of adopting three different estimated glomerular filtration rates based on creatinine in adult populations: a call for performance validation |
| title_full | The varied Q creatinine in multi ethnics population and impact of adopting three different estimated glomerular filtration rates based on creatinine in adult populations: a call for performance validation |
| title_fullStr | The varied Q creatinine in multi ethnics population and impact of adopting three different estimated glomerular filtration rates based on creatinine in adult populations: a call for performance validation |
| title_full_unstemmed | The varied Q creatinine in multi ethnics population and impact of adopting three different estimated glomerular filtration rates based on creatinine in adult populations: a call for performance validation |
| title_short | The varied Q creatinine in multi ethnics population and impact of adopting three different estimated glomerular filtration rates based on creatinine in adult populations: a call for performance validation |
| title_sort | varied q creatinine in multi ethnics population and impact of adopting three different estimated glomerular filtration rates based on creatinine in adult populations a call for performance validation |
| topic | creatinine Q creatinine EGFR kidney function non-communicable disease |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1467503/full |
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