IPSC-induced podocytes from a BORS patient with EYA1 gene mutation showed glucocorticoid-resistant and cytoskeletal rearrangement

IPSC-induced podocytes from a BORS patient with EYA1 gene mutation showed glucocorticoid-resistant and cytoskeletal rearrangement

Abstract         The primary cause of branchio-oto-renal syndrome (BORS) is mutations in the EYA1 gene. The aim of this study was to investigate the clinical characteristics associated with induced podocyte reappearance in children with BORS and EYA1 mutations. We collected clinical and genetic data...

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Bibliographic Details
Main Authors: Guanyu Li, Di Lu, Liujing Xu, Shumin Zhou, Jiayi Zhang, Lijuan Wu, Lingna Shi, Lili Wang, Xiaoqing Lin, Zhigang Ma, Ming Liu, Xia Gao
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
Branchio-oto-renal syndrome
Induced pluripotent stem cells
Podocytes
Online Access:https://doi.org/10.1007/s00018-025-05724-7
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