The association between tumor-stromal collagen features and the clinical outcomes of patients with breast cancer: a systematic review

The association between tumor-stromal collagen features and the clinical outcomes of patients with breast cancer: a systematic review

Abstract Background The tumor microenvironment (TME), particularly the extracellular matrix (ECM), plays a crucial role in regulating breast cancer progression. Among ECM components, collagen type I—accounting for over 90% of fibrillar collagen in the human body—is the primary structural component o...

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Bibliographic Details
Main Authors: Samane Heydari, Fatemeh Tajik, Sadegh Safaei, Fereshteh Kamani, Babak Karami, Shima Dorafshan, Zahra Madjd, Roya Ghods
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Breast Cancer Research
Subjects:
Collagen type I
Breast cancer
Extracellular matrix
Tumor microenvironment
Prognostic marker
Systematic review
Online Access:https://doi.org/10.1186/s13058-025-02017-6
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