The burden of ischemic stroke in Eastern Europe from 1990 to 2021
Abstract Background and purpose Ischemic stroke is a significant public health concern, particularly in Eastern Europe, where the burden remains high. This study aims to evaluate the trends and burden of ischemic stroke in Eastern Europe from 1990 to 2021, providing insights into epidemiological cha...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-025-04081-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849715667532513280 |
|---|---|
| author | Jingyao Xu Shuai Hou Zimeng Chen Yong Liu Xia Deng Chunping Wang Shijie Liu Yanqiang Wang |
| author_facet | Jingyao Xu Shuai Hou Zimeng Chen Yong Liu Xia Deng Chunping Wang Shijie Liu Yanqiang Wang |
| author_sort | Jingyao Xu |
| collection | DOAJ |
| description | Abstract Background and purpose Ischemic stroke is a significant public health concern, particularly in Eastern Europe, where the burden remains high. This study aims to evaluate the trends and burden of ischemic stroke in Eastern Europe from 1990 to 2021, providing insights into epidemiological changes and informing public health strategies. Methods We used data from the Global Burden of Disease 2021 database to comprehensively assess regional and national ischemic stroke indicators in Eastern Europe. These indicators included the number of cases, incidence, number of deaths, mortality, disability-adjusted life years (DALYs), DALY rates, and estimated annual percentage change (EAPC). Joinpoint analysis was employed to examine sex-specific time trends in the burden of ischemic stroke across Eastern European countries. These estimates incorporated the Socio-Demographic Index (SDI). Results In 2021, Eastern Europe reported 490,197 cases of ischemic stroke, with an age-standardized incidence rate (ASIR) of 142.57 (95% UI: 122.12 to 164.67), exceeding the global level. The region recorded 329,291 deaths, with an age-standardized mortality rate (ASMR) of 90.99 (95% UI: 82.79 to 98.48), significantly higher than the global rate. Disability-adjusted life years (DALYs) totaled 5,713,718, with an age-standardized DALYs rate (ASDR) of 1601.20 (95% UI: 1483.51 to 1723.12). Our joinpoint regression analysis indicates that the disease burden remains notably high in Eastern Europe, despite an overall declining trend from 1990 to 2021 in ASIR and ASMR across most countries, with estimated annual percentage changes (EAPC) of -1.13 (95% CI: -1.24 to -1.02) and − 2.78 (95% CI: -3.24 to -2.32), respectively. Lithuania reported the highest incidence rate, while the Russian Federation had the highest mortality and DALY rate. Conversely, Estonia showed significant improvements in stroke indicators. Key risk factors included low temperature and smoking, contributing notably to environmental and behavioral risks. Conclusion Ischemic stroke continues to be a significant global health issue. Our temporal trends study results indicate that the disease burden remains notably high in Eastern Europe, particularly in Lithuania and the Russian Federation. |
| format | Article |
| id | doaj-art-e582ce80446b412d8d5d260ac7004017 |
| institution | DOAJ |
| issn | 1471-2377 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj-art-e582ce80446b412d8d5d260ac70040172025-08-20T03:13:15ZengBMCBMC Neurology1471-23772025-02-012511910.1186/s12883-025-04081-zThe burden of ischemic stroke in Eastern Europe from 1990 to 2021Jingyao Xu0Shuai Hou1Zimeng Chen2Yong Liu3Xia Deng4Chunping Wang5Shijie Liu6Yanqiang Wang7Emergency Department, The Affiliated Hospital of Shandong Second Medical UniversityEmergency Department, The Affiliated Hospital of Shandong Second Medical UniversityDepartment II of Neurology, The Affiliated Hospital of Shandong Second Medical UniversityEmergency Department, The Affiliated Hospital of Shandong Second Medical UniversitySchool of Public Health, Shandong Second Medical UniversitySchool of Public Health, Shandong Second Medical UniversityEmergency Department, Yantai Laiyang Central HospitalDepartment II of Neurology, The Affiliated Hospital of Shandong Second Medical UniversityAbstract Background and purpose Ischemic stroke is a significant public health concern, particularly in Eastern Europe, where the burden remains high. This study aims to evaluate the trends and burden of ischemic stroke in Eastern Europe from 1990 to 2021, providing insights into epidemiological changes and informing public health strategies. Methods We used data from the Global Burden of Disease 2021 database to comprehensively assess regional and national ischemic stroke indicators in Eastern Europe. These indicators included the number of cases, incidence, number of deaths, mortality, disability-adjusted life years (DALYs), DALY rates, and estimated annual percentage change (EAPC). Joinpoint analysis was employed to examine sex-specific time trends in the burden of ischemic stroke across Eastern European countries. These estimates incorporated the Socio-Demographic Index (SDI). Results In 2021, Eastern Europe reported 490,197 cases of ischemic stroke, with an age-standardized incidence rate (ASIR) of 142.57 (95% UI: 122.12 to 164.67), exceeding the global level. The region recorded 329,291 deaths, with an age-standardized mortality rate (ASMR) of 90.99 (95% UI: 82.79 to 98.48), significantly higher than the global rate. Disability-adjusted life years (DALYs) totaled 5,713,718, with an age-standardized DALYs rate (ASDR) of 1601.20 (95% UI: 1483.51 to 1723.12). Our joinpoint regression analysis indicates that the disease burden remains notably high in Eastern Europe, despite an overall declining trend from 1990 to 2021 in ASIR and ASMR across most countries, with estimated annual percentage changes (EAPC) of -1.13 (95% CI: -1.24 to -1.02) and − 2.78 (95% CI: -3.24 to -2.32), respectively. Lithuania reported the highest incidence rate, while the Russian Federation had the highest mortality and DALY rate. Conversely, Estonia showed significant improvements in stroke indicators. Key risk factors included low temperature and smoking, contributing notably to environmental and behavioral risks. Conclusion Ischemic stroke continues to be a significant global health issue. Our temporal trends study results indicate that the disease burden remains notably high in Eastern Europe, particularly in Lithuania and the Russian Federation.https://doi.org/10.1186/s12883-025-04081-zDisease burden of ischemic strokeEastern EuropeDisability-adjusted life yearIncidenceMortality |
| spellingShingle | Jingyao Xu Shuai Hou Zimeng Chen Yong Liu Xia Deng Chunping Wang Shijie Liu Yanqiang Wang The burden of ischemic stroke in Eastern Europe from 1990 to 2021 BMC Neurology Disease burden of ischemic stroke Eastern Europe Disability-adjusted life year Incidence Mortality |
| title | The burden of ischemic stroke in Eastern Europe from 1990 to 2021 |
| title_full | The burden of ischemic stroke in Eastern Europe from 1990 to 2021 |
| title_fullStr | The burden of ischemic stroke in Eastern Europe from 1990 to 2021 |
| title_full_unstemmed | The burden of ischemic stroke in Eastern Europe from 1990 to 2021 |
| title_short | The burden of ischemic stroke in Eastern Europe from 1990 to 2021 |
| title_sort | burden of ischemic stroke in eastern europe from 1990 to 2021 |
| topic | Disease burden of ischemic stroke Eastern Europe Disability-adjusted life year Incidence Mortality |
| url | https://doi.org/10.1186/s12883-025-04081-z |
| work_keys_str_mv | AT jingyaoxu theburdenofischemicstrokeineasterneuropefrom1990to2021 AT shuaihou theburdenofischemicstrokeineasterneuropefrom1990to2021 AT zimengchen theburdenofischemicstrokeineasterneuropefrom1990to2021 AT yongliu theburdenofischemicstrokeineasterneuropefrom1990to2021 AT xiadeng theburdenofischemicstrokeineasterneuropefrom1990to2021 AT chunpingwang theburdenofischemicstrokeineasterneuropefrom1990to2021 AT shijieliu theburdenofischemicstrokeineasterneuropefrom1990to2021 AT yanqiangwang theburdenofischemicstrokeineasterneuropefrom1990to2021 AT jingyaoxu burdenofischemicstrokeineasterneuropefrom1990to2021 AT shuaihou burdenofischemicstrokeineasterneuropefrom1990to2021 AT zimengchen burdenofischemicstrokeineasterneuropefrom1990to2021 AT yongliu burdenofischemicstrokeineasterneuropefrom1990to2021 AT xiadeng burdenofischemicstrokeineasterneuropefrom1990to2021 AT chunpingwang burdenofischemicstrokeineasterneuropefrom1990to2021 AT shijieliu burdenofischemicstrokeineasterneuropefrom1990to2021 AT yanqiangwang burdenofischemicstrokeineasterneuropefrom1990to2021 |