Female sex is associated with short-term mortality in coronary artery bypass grafting patients: A propensity-matched analysis
Background: Females undergoing coronary artery bypass grafting (CABG) surgery have been reported to be at increased risk of postoperative mortality and comorbidity. Our main objective is to evaluate the impact of female sex on 30-day mortality after isolated CABG surgery. Methods: We created a retro...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025001033 |
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| author | Mostafa Abbas Thomas Morland Rohit Sharma Jeffrey Shuhaiber H. Lester Kirchner Yasser El-Manzalawy |
| author_facet | Mostafa Abbas Thomas Morland Rohit Sharma Jeffrey Shuhaiber H. Lester Kirchner Yasser El-Manzalawy |
| author_sort | Mostafa Abbas |
| collection | DOAJ |
| description | Background: Females undergoing coronary artery bypass grafting (CABG) surgery have been reported to be at increased risk of postoperative mortality and comorbidity. Our main objective is to evaluate the impact of female sex on 30-day mortality after isolated CABG surgery. Methods: We created a retrospective cohort of adult patients underwent isolated CABG surgery between 2006 and 2020 in a large rural healthcare system. Patients were grouped by sex and a 1:1 nearest neighbor propensity score matching method was performed to reduce the bias due to potential confounding. Association between female sex and 30-day mortality was assessed using conditional regression analysis and appropriate statistical tests for matched analyses. Associations between female sex and eight secondary outcomes were also considered. Results: Out of 5616 adult patients underwent isolated CABG surgery, 1352 were females. The propensity scoring matching method provided 1346 matched pairs with no observed significant imbalance for any of the included confounders. The conditional logistic regression analysis showed independent association between female sex and 30-day mortality (OR = 1.83, CI = 1.10–3.04, p = 0.02). Conclusions: Females undergoing isolated CABG surgery were at significantly greater risk of postoperative 30-day mortality and longer postoperative length of stay. Further research is needed to identify and address the causes of these disparities. |
| format | Article |
| id | doaj-art-e5802ba343e24699ae065ffffbeb88d1 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-e5802ba343e24699ae065ffffbeb88d12025-02-02T05:28:01ZengElsevierHeliyon2405-84402025-01-01112e41723Female sex is associated with short-term mortality in coronary artery bypass grafting patients: A propensity-matched analysisMostafa Abbas0Thomas Morland1Rohit Sharma2Jeffrey Shuhaiber3H. Lester Kirchner4Yasser El-Manzalawy5Department of Population Health Sciences, Geisinger, Danville, PA, USADepartment of Population Health Sciences, Geisinger, Danville, PA, USA; Department of General Internal Medicine, Geisinger, Danville, PA, USADepartment of General Internal Medicine, Geisinger, Danville, PA, USAGeisinger Heart Institute, Geisinger, Danville, PA, USADepartment of Population Health Sciences, Geisinger, Danville, PA, USADepartment of Population Health Sciences, Geisinger, Danville, PA, USA; Corresponding author. Department of Population Health Sciences, Geisinger Henry Hood Center for Health Research, 100 N. Academy Avenue Danville, PA, 17822-4400, USA.Background: Females undergoing coronary artery bypass grafting (CABG) surgery have been reported to be at increased risk of postoperative mortality and comorbidity. Our main objective is to evaluate the impact of female sex on 30-day mortality after isolated CABG surgery. Methods: We created a retrospective cohort of adult patients underwent isolated CABG surgery between 2006 and 2020 in a large rural healthcare system. Patients were grouped by sex and a 1:1 nearest neighbor propensity score matching method was performed to reduce the bias due to potential confounding. Association between female sex and 30-day mortality was assessed using conditional regression analysis and appropriate statistical tests for matched analyses. Associations between female sex and eight secondary outcomes were also considered. Results: Out of 5616 adult patients underwent isolated CABG surgery, 1352 were females. The propensity scoring matching method provided 1346 matched pairs with no observed significant imbalance for any of the included confounders. The conditional logistic regression analysis showed independent association between female sex and 30-day mortality (OR = 1.83, CI = 1.10–3.04, p = 0.02). Conclusions: Females undergoing isolated CABG surgery were at significantly greater risk of postoperative 30-day mortality and longer postoperative length of stay. Further research is needed to identify and address the causes of these disparities.http://www.sciencedirect.com/science/article/pii/S2405844025001033Coronary artery bypass graftingOutcomesGenderDisparitiesMortality |
| spellingShingle | Mostafa Abbas Thomas Morland Rohit Sharma Jeffrey Shuhaiber H. Lester Kirchner Yasser El-Manzalawy Female sex is associated with short-term mortality in coronary artery bypass grafting patients: A propensity-matched analysis Heliyon Coronary artery bypass grafting Outcomes Gender Disparities Mortality |
| title | Female sex is associated with short-term mortality in coronary artery bypass grafting patients: A propensity-matched analysis |
| title_full | Female sex is associated with short-term mortality in coronary artery bypass grafting patients: A propensity-matched analysis |
| title_fullStr | Female sex is associated with short-term mortality in coronary artery bypass grafting patients: A propensity-matched analysis |
| title_full_unstemmed | Female sex is associated with short-term mortality in coronary artery bypass grafting patients: A propensity-matched analysis |
| title_short | Female sex is associated with short-term mortality in coronary artery bypass grafting patients: A propensity-matched analysis |
| title_sort | female sex is associated with short term mortality in coronary artery bypass grafting patients a propensity matched analysis |
| topic | Coronary artery bypass grafting Outcomes Gender Disparities Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025001033 |
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