Central nervous system relapse in triple-negative breast cancer patients achieving pathological complete response after neoadjuvant chemotherapy: A retrospective cohort analysis

Central nervous system relapse in triple-negative breast cancer patients achieving pathological complete response after neoadjuvant chemotherapy: A retrospective cohort analysis

Triple-negative breast cancer (TNBC) is associated with an increased risk of distant metastases. While pathological complete response (pCR) after neoadjuvant chemotherapy predicts favorable outcomes, data suggest it may not uniformly protect against central nervous system (CNS) relapse.This study an...

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Main Authors: Gabriel Berlingieri Polho, Yumi Ricucci Shinkado, Leticia Kimie Murazawa, Vinicius Vitor Oliveira, Victor Rocha Pinheiro, Diana del Cisne Pineda Labanda, Romualdo Barroso-Sousa, Luciana Rodrigues Carvalho Barros, Laura Testa, Renata Colombo Bonadio
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Breast
Subjects:
Triple-negative
Breast cancer
Neoadjuvant
Recurrence
Online Access:http://www.sciencedirect.com/science/article/pii/S0960977625005703
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Summary:Triple-negative breast cancer (TNBC) is associated with an increased risk of distant metastases. While pathological complete response (pCR) after neoadjuvant chemotherapy predicts favorable outcomes, data suggest it may not uniformly protect against central nervous system (CNS) relapse.This study analyzed 774 TNBC patients to assess recurrence patterns. While CNS recurrences were numerically lower in pCR patients (5.0 % vs 8.8 %, p = 0.11), they represented a significantly higher proportion of all relapses in this group (50.0 % vs 20.2 %, p = 0.003). These results suggest that while pCR reduces overall recurrence risk, there is a distinct pattern of CNS-predominant failure.
ISSN:1532-3080

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