Coats disease in infants, toddlers, and preschoolers: Clinical presentation and treatment outcomes
Purpose: To study the stage of presentation, clinical features, and treatment outcomes of patients diagnosed with Coats disease in infants, toddlers, and preschoolers (aged ≤5 years). Methods: A retrospective hospital-based study of 98 patients with Coats disease was conducted. Results: The mean age...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_2477_24 |
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| Summary: | Purpose:
To study the stage of presentation, clinical features, and treatment outcomes of patients diagnosed with Coats disease in infants, toddlers, and preschoolers (aged ≤5 years).
Methods:
A retrospective hospital-based study of 98 patients with Coats disease was conducted.
Results:
The mean age at presentation was 30 months (range, 4–60 months). Majority were males (n = 72, 73%) with unilateral presentation (n = 98, 100%). The most common stages at presentation were total retinal detachment (stage 3B; 36%), advanced end-stage disease (stage 5; 22%), and total retinal detachment with secondary glaucoma (stage 4; 16%). The most common cause of referral to our institution was Coats disease (n = 23, 49%), followed by retinoblastoma (n = 17, 36%). The most common presenting symptom was a white reflex (n = 49, 50%) or strabismus observed by the parents (n = 34, 35%). Treatment modalities included observation (n = 30 eyes, 31%), surgical intervention (n = 22, 22%), and laser photocoagulation ± cryotherapy ± intravitreal injection (n = 22, 22%). At a mean follow-up of 29 months (range, 1–100 months), the anatomical status of the disease remained unchanged in 35 eyes (36%), worsened in 18 eyes (18%), and resolved in 15 eyes (15%). Ten eyes (10%) underwent enucleation. At the last follow-up, two-thirds of eyes (n = 76) had visual acuity ≤20/400 and were categorized as blind.
Conclusion:
Coats disease in patients ≤5 years presents at an advanced stage (3B or more). At the last follow-up, the disease had stabilized in half of the eyes, whereas two-thirds of the eyes were blind, necessitating early diagnosis and treatment. |
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| ISSN: | 0301-4738 1998-3689 |